“…The studies have different study designs, end points and durations of follow-up. [16][17][18][19][20] Taking these studies together, surveillance biopsies detected ACR (>grade A2) in approximately 13.6% of clinically silent cases, the majority within the first 4-6 months after transplant. 21 There is only one published study investigating the role of surveillance bronchoscopies in detecting ACR in children after lung transplantation.…”
“…The studies have different study designs, end points and durations of follow-up. [16][17][18][19][20] Taking these studies together, surveillance biopsies detected ACR (>grade A2) in approximately 13.6% of clinically silent cases, the majority within the first 4-6 months after transplant. 21 There is only one published study investigating the role of surveillance bronchoscopies in detecting ACR in children after lung transplantation.…”
“…In solid-organ transplant recipients, FOB has a diagnostic yield that varies between 27% and 85%, 18,21,[26][27][28][29][30][31][32] and the addition of TBB tends to increase the diagnostic yield compared with BAL alone. In a retrospective study of 104 immunosuppressed patients of whom 14.4% were solid-organ transplant recipients, 26 the combination of TBB and BAL increased the diagnostic yield to 70% when compared with BAL alone 38%.…”
Section: Diagnostic Yield and Impact Of The Results Of Fiber-optic Brmentioning
“…Se han descrito desde un 15 a un 40% de biopsias positivas, lo que supone una posible progresión de estos estadios clínicos hacia el desarrollo del BOS 84 . Por otro lado, la mayor parte de los casos detectados son estadios iniciales que frecuentemente se resuelven de manera espontánea 89 , lo que plantea el problema de qué debe hacerse con estos estadios iniciales asintomá-ticos y hasta cuándo debemos realizar estas biopsias de seguimiento 90 . La recomendación más frecuente es tratar incluso los estadios iniciales y prolongar el seguimiento por lo menos un año.…”
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