Diagnostic Yield Improves With Collection of 2 Samples in Fecal Immunochemical Test Screening Without Affecting Attendance

Roon, Aafke H C van; Wilschut, Janneke; Hol, Lieke; Ballegooijen, Marjolein van; Reijerink, Jacqueline C.; Mannetje, Hans 't; Kranenburg, Laura; Biermann, Katharina; Vuuren, Anneke J. van; Francke, Jan; Togt, A C M van der; Habbema, Dik J.F.; Leerdam, Monique E. van; Kuipers, Ernst J.

doi:10.1016/j.cgh.2010.12.012

Cited by 82 publications

(78 citation statements)

References 17 publications

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“…These studies have shown that FIT is highly sensitive for detecting CRC, its accuracy for AN is adequate and it is a cost-effective test in the CRC screening setting. [20][21][22][23][24][25][26][27][28][29][30] However, no studies have compared the diagnostic accuracy between these populations of a quantitative FIT so far. Only one recently published study has compared the diagnostic yield of a qualitative FIT in these two populations, and the authors did not find differences in FIT yield either.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening

et al. 2014

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Background: There is little information about the fecal immunochemical test (FIT) in familial-risk colorectal cancer (CRC) screening. Objectives: The objective of this article is to investigate whether FIT diagnostic accuracy for advanced neoplasia (AN) differs between average and familial-risk (first-degree relative) patients. Methods: A total of 1317 consecutive participants (595 familial) who collected one stool sample before performing a colonoscopy as a CRC screening test were included. FIT diagnostic accuracy for AN was evaluated with Chi-square test at a 20 mg hemoglobin/g of feces cut-off value. Finally, we determined which variables were independently related to AN. Results: An AN was found in 151 (11.5%) patients. The overall accuracy was not statistically different between both cohorts for AN (88.4%, 91.7%; p ¼ 0.051). At the cut-off stablished, differences in FIT sensitivity (31.1%, 40.6%; p ¼ 0.2) or specificity (96.5%, 97.3%; p ¼ 0.1) were not statistically significant. Finally, independent variables such as sex (male) (odds ratio (OR) 2.1, 95% confidence interval (CI) 1.4-3.1), age (50-65, >65 years) (OR 2.1, 95% CI 1.1-4.3; OR 2.7, 95% CI 1.2-6.1), previous colonoscopy (OR 0.4, 95% CI 0.2-0.9) and FIT 20 mg/g feces (OR 17.7, 95% CI 10.8-29.1) were associated with AN diagnosis. Conclusions: FIT accuracy for AN detection is equivalent in average and familial-risk CRC screening cohorts.

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening

et al. 2014

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“…Es gibt Daten, die zeigen, dass die Testung von mehreren Stuhlproben die Sensitivität erhöht [144 -146]. Eine Untersuchung aus den Niederlanden konnte jedoch zeigen, dass durch eine Absenkung des Grenzwerts ein ähnlicher Effekt erzielt werden kann [147].…”

Section: Level Of Evidence 3aunclassified

S3-Leitlinie – Kolorektales Karzinom

Schmiegel

Buchberger

Follmann³

et al. 2017

Z Gastroenterol

148

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“…23,24 Repeating the test might also improve the PPV without impacting the NPV. 25 FC offers the promise of a risk stratification for all patients with lower gastrointestinal symptoms, rather than the current focus on those with suspected colorectal cancer that distorts clinical thinking and becomes increasingly inefficient as the symptombased predictive value falls ever lower. 8 Large-scale, primary care based studies are required here.…”

Section: Implications For Research and Practicementioning

confidence: 99%

Faecal calprotectin in patients with suspected colorectal cancer: a diagnostic accuracy study

Turvill¹,

Aghahoseini²,

Sivarajasingham³

et al. 2016

Br J Gen Pract

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Diagnostic Yield Improves With Collection of 2 Samples in Fecal Immunochemical Test Screening Without Affecting Attendance

Cited by 82 publications

References 17 publications

Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening

Diagnostic accuracy of fecal immunochemical test in average‐ and familial‐risk colorectal cancer screening

S3-Leitlinie – Kolorektales Karzinom

Faecal calprotectin in patients with suspected colorectal cancer: a diagnostic accuracy study

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