Diagnostic Values of Serum Levels of Homocysteine and Uric Acid for Predicting Vascular Mild Cognitive Impairment in Patients with Cerebral Small Vessel Disease

Wang, Ting; Sun, Zimin; Shao, Liang-Qing; Xu, Xiaobin; Liu, Yang; Qin, Mei; Weng, Xiang; Zhang, Yongxiang

doi:10.12659/msm.901652

Cited by 17 publications

(11 citation statements)

References 37 publications

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“…In the non-brain injury group, positive signals may exist due to the severity of the disease and abnormalities, but the positive rate is low (20,34,35). It has been reported that serum HCY has high sensitivity and specificity in vascular mild cognitive dysfunction in patients with cerebral small vessel disease, and can be used as a predictor of vascular mild cognitive dysfunction in patients with cerebrovascular disease (36). PCT can be used as a rapid and accurate reference for early diagnosis of severe brain injury complicated with pulmonary infection (37), and serum PCT was a more sensitive indicator for predicting the risk of multiple organ dysfunction syndrome or death in patients with brain injury (38).…”

Section: Groupsmentioning

confidence: 99%

Diagnostic value of combination of cranial MRI, serum homocysteine and procalcitonin for hyperbilirubinemia complicated with brain injury in neonates

Chang

Wang

2020

Exp Ther Med

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The present study aimed to explore the diagnostic value of the combination of cranial magnetic resonance imaging (MRI), serum homocysteine (HCY) and procalcitonin (PCT) for hyperbilirubinemia complicated with brain injury in neonates. One hundred and forty-nine children with hyperbilirubinemia admitted to Shandong Medical Imaging Research Institute from January 2014 to April 2016 were collected as research subjects, and were divided into a brain injury group (n=67) and a non-brain injury group (n=82) according to whether children suffered from brain injury. PCT levels were detected by electrochemiluminescence (ECL), and HCY levels by enzymatic cycling assay (ECA). The combination of cranial MRI, HCY and PCT was used to diagnose hyperbilirubinemia complicated with brain injury in neonates. The concentrations of HCY and PCT in the brain injury group were significantly higher than those in the non-brain injury group (P<0.001). According to the MRI examination results, the patients were divided into an MRI normal group and an MRI abnormal group. In the brain injury group, the serum HCY and PCT levels of the MRI abnormal group were significantly higher than those of the MRI normal group, with a statistically significant difference (P<0.05). In the non-brain injury group, the serum HCY and PCT levels of the MRI abnormal group were significantly higher than those of the MRI normal group, with a statistically significant difference (P<0.05). The sensitivity of the combined detection was significantly higher than that of single detection (P<0.05); the specificity was significantly higher than that of HCY detection (P<0.05), and the accuracy was significantly higher than that of MRI and HCY single detection (P<0.05). In conclusion, the combination of cranial MRI, HCY and PCT, which has a high diagnostic value for hyperbilirubinemia complicated with brain injury in neonates, is conducive to the early diagnosis and timely treatment of the disease and the reduction of sequelae.

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Section: Groupsmentioning

confidence: 99%

Diagnostic value of combination of cranial MRI, serum homocysteine and procalcitonin for hyperbilirubinemia complicated with brain injury in neonates

Chang

Wang

2020

Exp Ther Med

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“…Previous studies found that an elevated SUA level was strongly related to vascular dementia, suggesting that SUA might be a risk factor. 8–11 However, some studies found that UA may have a protective effect on cognition. 5–7 A similar argument was also made in studies focusing on PSCI.…”

Section: Introductionmentioning

confidence: 99%

Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study

Liu¹,

Liao²,

Pan³

et al. 2021

NDT

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Purpose Cognitive impairment is a common complication after stroke and transient ischemic attack (TIA). The relationship between serum uric acid (SUA) and post-stroke cognitive impairment (PSCI) is controversial. This study evaluated the association of different SUA levels in the normal range and PSCI at 3 months. Patients and Methods A total of 1523 patients with ischemic stroke/TIA were recruited from the Impairment of Cognition and Sleep (ICONS) subgroup of the China National Stroke Registry-3 (CNSR-3). SUA concentration was assessed at baseline. Global cognitive status was evaluated using the Montreal Cognitive Assessment (MoCA). The main clinical outcome was the incidence of PSCI assessed at 3 months after stroke/TIA. The association between SUA status and the risk of PSCI was assessed with multiple regression models adjusted for potential covariates. Results Among the 1523 patients (1391 (91.33%) stroke patients and 132 (8.67%) TIA patients), 747 (49.05%) patients had PSCI at 3 months. Compared to the reference group, there was an increased risk of PSCI in males with SUA levels in the first (OR=1.76) and fourth quartiles (OR=1.47). A U-shaped association between SUA levels and the incidence of PSCI with an inflection point of 297 mmol/L was also found in males. However, there was no association between SUA levels and PSCI in females. Conclusion The association between SUA and PSCI differed between males and females. In males, both low and high SUA levels were associated with relatively higher incidences of PSCI, supporting a U-shaped association between SUA levels and PSCI.

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“…Coronary atherosclerotic, the most common type of CHD, is caused by coronary atherosclerotic stenosis, which leads to necrosis of the myocardium due to the insufficient blood supply. In addition, broadly speaking, the stenosis of the lumen caused by extensive inflammation and embolism also lead to CHD [1]. For a long time, the "gold standard" for evaluating the severity of coronary artery lesions has been the coronary angiography, but it is too traumatic to be suitable for elderly patients.…”

Section: Introductionmentioning

confidence: 99%

Increased levels of serum Hcy and UA as well as the thickness of carotid intima-media correlates with the severity of coronary artery lesions

Tan

2020

Preprint

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Background: To investigate the correlation between serum homocysteine (Hcy) and uric acid (UA) levels as well as the carotid intima-media thickness (IMT) and the severity of coronary artery lesions in elderly patients with coronary heart disease (CHD). Methods: A total of 156 elderly patients (≥60 years old) with CHD were recruited in the study group; 54 healthy subjects were selected as the control group. Serum Hcy and UA levels, IMT, SYNTAX score and Sullivan scores were measured and analyzed by Pearson correlation. The study group were further divided into low (≤20 points, n=72), middle (21-39 points, n=56) and high (≥40 points, n=28) score groups according to their SYNTAX score and the levels of other indexes between them were compared. The risk factors for CHD and the correlation were analyzed by univariate analysis and logistic regression. Results: SYNTAX scores showed that the levels of serum Hcy, UA, and the IMT in middle [(20.03 ± 7.88) μmol/L, (326.34 ± 79.34) μmol/L, (1.26 ± 0.07) mm)] and high score [(28.98 ± 8.04) μmol/L, (456.67 ± 98.34) μmol/L, (1.33 ± 0.08) mm] groups were significantly higher compared to the low score group [(11.34 ± 3.83) μmol/L, (206.78 ± 60.45) μmol/L, (1.19 ± 0.05) mm)], while the high score group had the highest levels (all P < 0.001). Serum Hcy, UA levels and the IMT were positively correlated with SYNTAX and Sullivan scores (all P < 0.001). Additionally, male gender, smoking, history of hypertension, systolic pressure, pulse pressure, Hcy, UA, IMT, and BMI independently correlated with the severity of CHD (all P < 0.05). Conclusions: The serum levels of Hcy and UA and the IMT in patients with CHD were significantly elevates, and positively correlated with the severity of coronary artery lesions, which may serve as diagnostic indicators.

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Diagnostic Values of Serum Levels of Homocysteine and Uric Acid for Predicting Vascular Mild Cognitive Impairment in Patients with Cerebral Small Vessel Disease

Cited by 17 publications

References 37 publications

Diagnostic value of combination of cranial MRI, serum homocysteine and procalcitonin for hyperbilirubinemia complicated with brain injury in neonates

Diagnostic value of combination of cranial MRI, serum homocysteine and procalcitonin for hyperbilirubinemia complicated with brain injury in neonates

Association Between Serum Uric Acid Levels and Cognitive Function in Patients with Ischemic Stroke and Transient Ischemic Attack (TIA): A 3-Month Follow-Up Study

Increased levels of serum Hcy and UA as well as the thickness of carotid intima-media correlates with the severity of coronary artery lesions

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