Diagnostic values of HNP 1-3 and procalcitonin levels in synovial fluid aspirates in the differential diagnosis between septic arthritis and noninfectious arthritis

Role of serum and synovial procalcitonin in differentiating septic from non-septic arthritis- a prospective study

“…ROC curve analysis showed that AUC for synovial PCT was greater than serum PCT suggesting that synovial PCT has a higher ability to differentiate septic from non-septic arthritis. Similar ROC curve analysis was derived by Wang et al and D Akdogan et al 25,26 There were a few limitations in our studies. We did not include periprosthetic joint infections as most of them are chronic.…”

“…Wang et al and D. Akdo gan et al found that synovial PCT may be a better alternative than serum PCT with higher sensitivity and specificity in accordance with our study. 25,26 However, none of these studies has compared serum and synovial PCT in the presumed pyogenic vs non-septic arthritis group. Our study found that PCT levels both in the serum as well as the synovial fluid were significantly higher even in the presumed pyogenic group as compared to the non-septic group.…”

Atypical Staphylococcal Septic Arthritis in a Native Hip: A Case Report and Review

“…Zhao et al revealed that procalcitonin has a higher specificity than CRP when using a cutoff of 0.5 ng/mL or greater and may deserve attention as a marker for septic arthritis [ 23 ]. Akdoğan et al found that the sensitivity, specificity, and accuracy of synovial fluid procalcitonin was 60%, 100%, and 78%, respectively [ 24 ]. They also investigated the use of human neutrophil peptides 1-3 (HNP 1-3) with values of 86%, 87%, and 87%, respectively [ 24 ].…”

“…Akdoğan et al found that the sensitivity, specificity, and accuracy of synovial fluid procalcitonin was 60%, 100%, and 78%, respectively [ 24 ]. They also investigated the use of human neutrophil peptides 1-3 (HNP 1-3) with values of 86%, 87%, and 87%, respectively [ 24 ]. Lastly, they concluded that when used in conjunction, the two markers in synovial fluid accurately diagnosed 97% of cases [ 24 ].…”

“…They also investigated the use of human neutrophil peptides 1-3 (HNP 1-3) with values of 86%, 87%, and 87%, respectively [ 24 ]. Lastly, they concluded that when used in conjunction, the two markers in synovial fluid accurately diagnosed 97% of cases [ 24 ].…”