Diagnostic value of Xpert® BC Detection, Bladder Epicheck®, Urovysion® FISH and cytology in the detection of upper urinary tract urothelial carcinoma

Pycha, Stefan; Trenti, Emanuela; Mian, Christine; Schwienbacher, Christine; Hanspeter, Esther; Palermo, Margherita; Pycha, Armin; Danuser, Hansjörg; D’Elia, Carolina

doi:10.1007/s00345-023-04350-x

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Previous reports have shown that FISH is more sensitive than urine cytology in diagnosing UTUC, but their specificity is similar ( 17 ). At present, FISH has become the main role in the diagnostic process of UTUC ( 12 , 18 ), which can clarify the presence of cancer cells in the urinary system and qualitatively analyze space occupying lesions in combination with imaging examinations. However, there are relatively few studies on FISH to evaluate the pathological characteristics of UTUC.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the diagnostic efficiency of voided urine fluorescence in situ hybridization for predicting the pathology of preoperative “low-risk” upper tract urothelial carcinoma

Xu¹,

Zhang²,

Yao³

et al. 2023

Front. Oncol.

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ObjectivesTo evaluate the clinical utility of voided urine fluorescence in situ hybridization (FISH) for predicting the pathology of preoperative “low-risk” upper tract urothelial carcinoma (UTUC).MethodsInformation of patients preoperatively diagnosed with “low-risk” UTUC receiving radical nephroureterectomy (RNU) between May 2014 and October 2019 were retrospectively collected. All of the patients accepted the FISH test and then were divided into two groups according to the results of FISH. The diagnostic value of FISH was assessed through the receiver operating characteristics (ROC) curve and area under the curve. Logistic regression analysis was applied to examine FISH as a predictive factor of tumor final stage and grade of preoperative “low-risk” UTUC.ResultsIn total, 129 patients were included. Of them, 70 (54.2%) were marked with positive FISH result. The difference at final pathology in tumor stage and tumor grade between these two groups of FISH (-) and FISH (+) had significantly statistical significance (p<0.001). Regarding to the tumor stage at final pathology, the sensitivity, specificity, positive predictive value and negative predictive value of FISH were 70.7 (58.9-80.3)68.5 (54.3-80.1)75.7 (63.7-84.8) and 62.7 (49.1-74.7), respectively. Regarding to the tumor grade at final pathology, the sensitivity, specificity, positive predictive value and negative predictive value of FISH were 64.7 (53.5-74.6), 65.9 (50.0-79.1), 78.6 (66.8-87.1) and 49.1 (36.5-62.3), respectively. The results of logistic regression analysis indicated that FISH could predict the pathologic characteristics of preoperative “low-risk” UTUC independently.ConclusionsFISH was qualified with relatively high diagnostic estimates for predicting tumor stage and grade of preoperative “low-risk” UTUC, and could be an independent predictive factor in clinical practice. For preoperative “low-risk” UTUC patients but with positive FISH result, choosing nephron-sparing surgery may require special caution.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the diagnostic efficiency of voided urine fluorescence in situ hybridization for predicting the pathology of preoperative “low-risk” upper tract urothelial carcinoma

Xu¹,

Zhang²,

Yao³

et al. 2023

Front. Oncol.

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Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?

Maestra

Benvenuti

D’Agostini

et al. 2023

Expert Review of Molecular Diagnostics

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Urinary markers for bladder cancer diagnosis: A review of current status and future challenges

Tomiyama,

Fujita,

Hashimoto

et al. 2023

Int J of Urology

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Bladder cancer is a common urological cancer with a high recurrence rate that requires long‐term follow‐up, and early detection positively affects prognosis. To date, the initial diagnosis and follow‐up for bladder cancer rely on cystoscopy, which is an invasive and expensive procedure. Therefore, urinary markers for the detection of bladder cancer have attracted research attention for decades to reduce unnecessary cystoscopies. Urine, which is in continuous contact with bladder cancer, is considered a suitable fluid for providing tumor information. Urinary cytology is the only widely used urinary marker in clinical practice; however, it has poor sensitivity for low‐grade tumors; indicating the need for novel urinary markers. Considerable research has been conducted on this topic over the years, resulting in a complex landscape with a wide range of urinary markers, including protein‐, exfoliated cell‐, RNA‐, DNA‐, and extracellular vesicle‐based markers. Although some of these markers have been approved by the U.S. Food and Drug Administration and are commercially available, their use in clinical practice is limited. To facilitate clinical application, potential urinary markers must withstand prospective clinical trials and be easy for patients and clinicians to understand and utilize in a clinical context. This review provides a comprehensive overview of currently available and recently reported promising urinary markers for bladder cancer. Additionally, the challenges and the prospects of these urinary markers for clinical implementation in bladder cancer treatment were discussed.

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Diagnostic value of Xpert® BC Detection, Bladder Epicheck®, Urovysion® FISH and cytology in the detection of upper urinary tract urothelial carcinoma

Cited by 4 publications

References 10 publications

Evaluation of the diagnostic efficiency of voided urine fluorescence in situ hybridization for predicting the pathology of preoperative “low-risk” upper tract urothelial carcinoma

Evaluation of the diagnostic efficiency of voided urine fluorescence in situ hybridization for predicting the pathology of preoperative “low-risk” upper tract urothelial carcinoma

Comet-FISH analysis of urothelial cells. A screening opportunity for bladder cancer?

Urinary markers for bladder cancer diagnosis: A review of current status and future challenges

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