Diagnostic value of visceral adiposity index in chronic kidney disease: a meta-analysis

Fang, Tingting; Zhang, Qiuling; Wang, Yanmei; Zha, Hui

doi:10.1007/s00592-023-02048-5

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…Previous research has primarily focused on traditional lipid profiles, often overlooking the potential of LAP index as a predictor for CKD. The present findings align with Fang et al (29), who reported a similar level of association and accuracy for visceral adiposity index and CKD. Notably, the present subgroup analysis indicated the differential impact of lipid accumulation in diabetic versus non-diabetic individuals, suggesting a possible interplay between metabolic status and renal health.…”

Section: Discussionsupporting

confidence: 93%

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

Wu,

Cui,

et al. 2024

Exp Ther Med

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Diabetes mellitus and lipid metabolism disorders are increasingly recognized as key contributors to the development of chronic kidney disease (CKD). The lipid accumulation product (LAP) index, a novel marker of lipid accumulation, has potential implications for CKD risk assessment. The present meta-analysis aimed to assess the association between LAP index and CKD, with an emphasis on varying impacts in diabetic and non-diabetic populations. A comprehensive search for relevant publications was performed using PubMed/MEDLINE, Scopus, Cochrane Library, ScienceDirect and Google Scholar databases, and a meta-analysis of 17 studies was performed to investigate the relationship between LAP index and CKD. The random-effects inverse-variance model employing the DerSimonian-Laird estimator for τ² was utilized to calculate pooled odds ratios (ORs). Diagnostic accuracy was assessed using summary receiver operating characteristic (ROC) curves, with calculations of the area under the ROC curve (AUROC), sensitivity, specificity, likelihood ratios and diagnostic OR. The pooled OR for the association between higher quintiles or tertiles of LAP index and CKD was 1.098 (95% CI: 1.043-1.152), with substantial heterogeneity (I²=91.2%) and evidence of publication bias. Subgroup analysis revealed a stronger association in non-diabetic (OR=2.422, 95% CI: 1.802-3.042) compared with diabetic patients (OR=1.018, 95% CI: 0.993-1.043). The diagnostic accuracy of LAP index for CKD was moderate (AUROC= 0.64), with sensitivity and specificity estimates of 0.58 and 0.63, respectively. In conclusion, in the present study, LAP index demonstrated a modest but significant association with CKD, particularly in non-diabetic patients. Despite its moderate diagnostic accuracy, the LAP index could serve as a valuable tool in CKD risk stratification, particularly when integrated with other clinical markers.

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Section: Discussionsupporting

confidence: 93%

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

Wu,

Cui,

et al. 2024

Exp Ther Med

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“…One study found that in older adults, VAI was associated with an increased risk of chronic kidney disease (CKD)-related events such as decreased glomerular filtration rate and rapid kidney function decline [ 23 ]. VAI can be a good predictor of CKD, with a prediction rate of 77% [ 24 ]. Excessive visceral fat deposition in patients with CKD increases the risk of all-cause mortality [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Liang,

Liu,

Yang

2023

BMC Nephrol

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Aim Our aim in this study was primarily to assess the relationship between visceral adiposity index (VAI) and the risk of kidney stones and kidney stone recurrence in US adults. Methods We used data from the National Health and Nutrition Examination Survey (NHANES) 2007–2014 for our analysis. VAI was calculated from waist circumference (WC), body mass index (BMI), triglycerides (TG), and high-density lipoprotein-cholesterol (HDL-C). Kidney stones and recurrence of kidney stones were obtained from questionnaire interview data. We used multivariate logistic regression analysis to explore the correlation between VAI and the risk of kidney stone and kidney stone recurrence. In addition, we performed subgroup analysis, interaction tests, and restricted cubic spline (RCS) analysis. Results A total of 9886 participants were included in this study, with a prevalence of 9.24% for kidney stones and 2.97% for recurrence of kidney stones. The prevalence of kidney stones and kidney stone recurrence increased with higher quartiles of VAI. We observed a significantly positive correlation between VAI and the risk of kidney stone and kidney stone recurrence. Participants with the highest VAI quartiles had a 48% (OR: 1.48, 95%CI: 1.08–2.02) and 52% (OR: 1.52, 95%CI: 0.86–2.71) increased risk of kidney stones and kidney stone recurrence, respectively, compared to participants with the lowest VAI quartiles. Subgroup analysis and interaction tests demonstrated this positive association independent of different subgroup factors. Conclusion Visceral fat accumulation may be associated with an increased risk of kidney stones and kidney stone recurrence.

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Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study

Tao,

Xu,

et al. 2024

BMC Public Health

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Diagnostic value of visceral adiposity index in chronic kidney disease: a meta-analysis

Cited by 4 publications

References 36 publications

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

Association between lipid accumulation product index and chronic kidney disease: A systematic review and meta-analysis

The association of visceral adiposity index with the risk of kidney stone and kidney stone recurrence

Association between physical activity and visceral adiposity index (VAI) in U.S. population with overweight or obesity: a cross-sectional study

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