Diagnostic Value of Upar, IL-33, and ST2 Levels in Childhood Sepsis

Çekmez, Ferhat; Fidanci, Muzaffer Kursat; Ayar, Ganime; Saldır, Mehmet; Karaoğlu, Abdülbaki; Gündüz, Ramiz Coşkun; Tunç, Turan; Kalkan, Gökhan

doi:10.7754/clin.lab.2014.141013

Cited by 11 publications

(8 citation statements)

References 2 publications

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“…Soluble ST2, a decoy receptor for the cytokine IL-33 (a member of the IL-1 family), has previously reported roles in activating immune cells and regulating the host response although preclinical studies report conflicting results on the roles of ST2 and IL33 depending on model design and choice of septic insult [40][41][42][43]. ST2 is undetectable in normal individuals but is both elevated in septic patients and is prognostic of increased mortality [44][45][46]. Interestingly, elevated levels of ST2 are associated with increased risk of diabetes mellites in both non-diabetic and prediabetic patient populations [47][48][49], whereas IL-33 may have protective roles in glycemic control [50,51].…”

Section: Plos Onementioning

confidence: 99%

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients

et al. 2021

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Hyperglycemia during sepsis is associated with increased organ dysfunction and higher mortality. The role of the host immune response in development of hyperglycemia during sepsis remains unclear. We performed a retrospective analysis of critically ill adult septic patients requiring mechanical ventilation (n = 153) to study the relationship between hyperglycemia and ten markers of the host injury and immune response measured on the first day of ICU admission (baseline). We determined associations between each biomarker and: (1) glucose, insulin, and c-peptide levels at the time of biomarker collection by Pearson correlation; (2) average glucose and glycemic variability in the first two days of ICU admission by linear regression; and (3) occurrence of hyperglycemia (blood glucose>180mg/dL) by logistic regression. Results were adjusted for age, pre-existing diabetes mellitus, severity of illness, and total insulin and glucocorticoid dose. Baseline plasma levels of ST2 and procalcitonin were positively correlated with average blood glucose and glycemic variability in the first two days of ICU admission in unadjusted and adjusted analyses. Additionally, higher baseline ST2, IL-1ra, procalcitonin, and pentraxin-3 levels were associated with increased risk of hyperglycemia. Our results suggest associations between the host immune response and hyperglycemia in critically ill septic patients particularly implicating the interleukin-1 axis (IL-1ra), the interleukin-33 axis (ST2), and the host response to bacterial infections (procalcitonin, pentraxin-3).

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Section: Plos Onementioning

confidence: 99%

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients

et al. 2021

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“…In addition, previous studies have revealed that the IL-33/ST2 axis demonstrates an adverse effect on the pathogenesis of systemic lupus erythematosus (51), as well as promoting tubular cell injury and interstitial fibrosis in obstructive kidney disease (52). Moreover, the serum levels of IL-33 and sST2 are elevated in patients with sepsis, suggesting the involvement of the IL-33/ST2 axis in the pathogenesis and progression of sepsis (53)(54)(55). Another study has demonstrated that IL-33 expression is upregulated in the serum and synovial fluid samples of patients with rheumatoid arthritis and is associated with disease progression (56).…”

Section: Il-33/st2 Axismentioning

confidence: 96%

Role of the IL‑33/ST2 receptor axis in ovarian cancer progression (Review)

et al. 2021

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“…An increasing body of evidence indicates that the IL-33/ST2 axis is involved in the initiation and progression of sepsis [88]. IL-33 and sST2 serum levels were elevated in sepsis patients [89,90,91,92]. Infection-induced renal dysfunction and AKI has also been described in moderate-to-severe scrub typhus [93].…”

Section: Il-33 In Acute Kidney Injurymentioning

confidence: 99%

Emerging Roles of IL-33/ST2 Axis in Renal Diseases

Chen

Yang

2017

IJMS

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Renal diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have a great impact on health care systems worldwide. Similar to cardiovascular diseases, renal diseases are inflammatory diseases involving a variety of cytokines. Primary causes of renal injury include ischemia, uremic toxins, bacteremia, or nephrotoxicity. Inflammation represents an important component following kidney injury. Interleukin (IL)-33 is a member of the IL-1 cytokine family, which is widely expressed in epithelial barrier tissues and endothelial cells, and mediates both tissue inflammation and repair responses. IL-33 is released as a nuclear alarmin in response to tissue damage and triggers innate and adaptive immune responses by binding to its receptor, suppression of tumorigenicity 2 (ST2). Recent evidence from clinical and experimental animal studies indicates that the IL-33/ST2 axis is involved in the pathogenesis of CKD, renal graft injury, systemic lupus nephritis, and AKI. In this review, we discuss the pathological and tissue reparative roles of the IL-33/ST2 pathway in different types of renal diseases.

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Diagnostic Value of Upar, IL-33, and ST2 Levels in Childhood Sepsis

Cited by 11 publications

References 2 publications

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients

Association of the systemic host immune response with acute hyperglycemia in mechanically ventilated septic patients

Role of the IL‑33/ST2 receptor axis in ovarian cancer progression (Review)

Emerging Roles of IL-33/ST2 Axis in Renal Diseases

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