Diagnostic Value of Transthoracic Echocardiography Combined With Contrast‐Enhanced Ultrasonography in Mediastinal Masses

Wang, Ding; Zhang, Jun; Liu, Yani; Sun, Ruiying; Hui, Hui; Zhao, Wei; Deng, Yansha

doi:10.1002/jum.14704

Cited by 9 publications

(4 citation statements)

References 17 publications

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“…The diagnosis of cardiac fibromas generally entails various imaging and laboratory tests, including echocardiography, computed tomography, and sometimes cardiac catheterization ( 8 ). Echocardiography is the most frequently employed diagnostic tool as it provides for the visualization of the location, size, and characteristics of a cardiac tumor ( 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

A rare morphology of the cardiac fibroma in a child: a case report

Tian,

Lin,

Yang

et al. 2024

Front. Cardiovasc. Med.

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Here we report a rare morphology of a cardiac fibroma in a child. A 2-year and 8-month-old toddler came for “chronic constipation” and was found to have a heart murmur on cardiac auscultation. Further transthoracic echocardiography suggested “a strong echogenic mass in the left ventricular wall, with some part of “a string of beads” in shape extending into left ventricle outflow tract”, which was atypical for either a tumor, thrombus or vegetation. The child underwent resection of the mass and mitral valvuloplasty. Pathological examination confirmed the mass as a cardiac fibroma.

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Section: Discussionmentioning

confidence: 99%

A rare morphology of the cardiac fibroma in a child: a case report

Tian,

Lin,

Yang

et al. 2024

Front. Cardiovasc. Med.

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“…In contrast, malignant thymic carcinoma often shows a hyperechoic occupancy with an unsmooth periphery, unclear border and uneven internal echoes. In addition, mediastinal lymphoma is often a well-defined hypoechoic mass with multiple fusions on US ( 36 , 37 ). Regarding the CEUS presentation of mediastinal tumors, Pan et al ( 38 ) found the specificity of CEUS was higher than that of contrast-enhanced MRI (CE-MRI), and the positive predictive value and diagnostic coincidence rate of CEUS were equal to those of CE-MRI, which means CEUS can be used as an effective alternative and complementary examination for patients who cannot undergo CE-MRI.…”

Section: Discussionmentioning

confidence: 99%

Imaging performance of thoracic SMARCA4-deficient undifferentiated tumor: a case report and literature review

Yang,

Wang

2024

Transl Lung Cancer Res

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Background SMARCA4-deficient undifferentiated tumor (SMARCA4-UT) is a class of high-grade malignant tumors that has only been described in recent years, with an undifferentiated or rhabdoid morphology and genetic deletion of SMARCA4 ( BRG1 ), a subunit of the BRG1 -associated factors (BAFs) chromatin remodeling complex. It is a rare tumor type that occurs in young to middle-aged men and usually presents as a compressive thoracic mass with rapid progression and poor prognosis. However, much remains unknown about the clinical and imaging manifestations of the disease. Case Description Herein, we report a 51-year-old man who came to our hospital with multiple enlarged lymph nodes in the chest after a computed tomography (CT) examination at another hospital. The patient underwent conventional ultrasound (US), contrast-enhanced ultrasound (CEUS), magnetic resonance imaging (MRI), 18 F-fluorodeoxyglucose positron emission tomography/CT (PET/CT), and finally confirmed the diagnosis of SMARCA4-UT by US-guided puncture biopsy. After symptomatic management, the patient was transferred to another hospital and we performed a short-term follow-up. Conclusions During this procedure, we obtained a series of relevant clinical and imaging data, especially US and CEUS images, which were described for the first time, offering valuable imaging information that will contribute to the clinical diagnosis of this disease to a certain extent. Moreover, this case highlights the efficacy of CEUS in identifying internal necrosis within tumors and lymph nodes, thereby improving the success rate of obtaining tumor tissue for pathological diagnosis. These findings substantiate the practical utility of US and CEUS in the context of mediastinal SMARCA4-UT, emphasizing their potential for widespread clinical adoption.

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“…TTE is not easy to detect small deep tumors in the posterior mediastinum due to the interference of lung gas. In addition, some studies [ 18 – 21 ] found that contrast-enhanced ultrasound can improve the targeting of fine-needle aspiration and identify the nature of mediastinal tumors.…”

Section: Discussionmentioning

confidence: 99%

The value of transthoracic echocardiography in the detection of extra-cardiac lesions

Yan

Ruan

et al. 2022

BMC Surg

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Objective Transthoracic echocardiography (TTE) is generally recognized as the top choice for detecting myocardial and cardiac cavity lesions. Sonographers mostly focus on myocardium, cardiac cavity and cardiac hemodynamics, whereas the abnormal extra-cardiac lesions are easily remain unrecognized. The aim of this study was to investigate the ultrasonic image features in abnormal extra-cardiac lesions and the value of TTE in the detection of extra-cardiac lesions. Methods 49 cases of abnormal extra-cardiac lesion detected by TTE from January 2014 to December 2019 were collected, which were confirmed by surgical pathology. The two-dimensional ultrasonic characteristics and the relationships with the cardiac and great vessels were summarized on the basis of multi-view by TTE. All patients were also examined by computed tomography (CT). Results In 49 patients with abnormal extra-cardiac lesions, 37 malignant cases and 12 benign cases were included. There were 41 cases (41/49, 86.67%) of mediastinal lesions and 8 cases (8/49, 16.33%) of lung lesions. The maximum diameter ranged from 3.2 cm to 13.66 cm, and the median diameter was about 7.4 cm, among which 29 cases (29/49, 59.18%) were larger than 5 cm. 4 cases (4/49, 8.16%) of cystic anechoic lesions were pericardial cyst. 2 cases (2/49, 4.08%) of cystic-solid echogenic lesions were teratoma. The remaining 43 cases (43/49, 87.76%) presented as solid hypoechoic or heterogeneous masses. 6 cases compressed the heart and 21 cases encroached on the heart and vessels. Diagnosis coincidence rates of TTE and CT were respectively 77.55% and 93.88%, with a statistical difference (p = 0.012). Conclusion Although the diagnostic coincidence rate of TTE is slightly lower than that of CT, TTE has certain diagnostic value for extra-cardiac lesions.

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Diagnostic Value of Transthoracic Echocardiography Combined With Contrast‐Enhanced Ultrasonography in Mediastinal Masses

Abstract: Transthoracic echocardiography is a useful method for diagnosing mediastinal. Further contrast-enhanced ultrasonography could provide more details on the degree of vascularization, which could facilitate accurate diagnosis and differentiation diagnosis.

Cited by 9 publications

References 17 publications

A rare morphology of the cardiac fibroma in a child: a case report

A rare morphology of the cardiac fibroma in a child: a case report

Imaging performance of thoracic SMARCA4-deficient undifferentiated tumor: a case report and literature review

The value of transthoracic echocardiography in the detection of extra-cardiac lesions

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