Diagnostic value of the soluble triggering receptor expressed on myeloid cells-1 in bacterial infection: a meta-analysis

Abstract

sTREM-1 represents a reliable biological marker of bacterial infection, but it may be not a sufficient biological marker for infection of the urinary tract as a result of its low sensitivity. Whether sTREM-1 guidance can reduce antibiotic use as well as the measurement of sTREM-1 in different types of infection will require additional prospective studies.

The significance of sTREM-1 as a diagnostic biomarker of sepsis in the context of Sepsis-3 definition

“…(25) Other studies also showed that sTREM is a sensitive marker for establishing the diagnosis of sepsis. (11,26) In the study that also tested the diagnostic value of sTREM-1 in patients with sepsis and sterile SIRS, concentrations of this biomarker were significantly higher in septic patients than in patients with sterile SIRS. (27) A meta-analysis, that included 11 studies and 1795 patients, found that sTREM had a sensitivity and specificity of 79% and 80% (respectively) in differentiation of sepsis from sterile SIRS.…”

Diagnostic and prognostic value of procalcitonin and sTREM-1 levels in sepsis

“…In Gibot et al 's study conducted to investigate the diagnostic values of both procalcitonin and sTREM-1, laboratory findings of both markers were higher in patients with sepsis (10). In another study investigating the diagnostic value of the sTREM-1 in patients with sepsis and NI-SIRS, sTREM-1 levels were significantly higher in patients with sepsis than in patients with NI-SIRS (17). In a metaanalysis of 13 studies, it was concluded that sTREM-1 levels could be considered a reliable biological marker in bacterial infections (18).…”

Diagnostic role of soluble triggering receptor expressed on myeloid cell-1 in patients with sepsis

“…[12][13][14] When sTREM-1 of plasma is >60 μg/L in ICU sepsis patients, it is more accurate than any other clinical or laboratory indicators in predicting infection and sepsis with a sensitivity of 96% and a specificity of 89%. [15] A study found that sTREM-1 concentration was significantly lower at admission in non-survivors than in survivors.…”