Diagnostic Value of the Nuclear Matrix Protein 22 Test and Urine Cytology in Upper Tract Urothelial Tumors

Jovanović, M.; Soldatović, Ivan; Janjic, Aleksandar; Vuksanović, Aleksandar; Džamić, Zoran; Acimovic, M.; Hadži-Djokić, Jovan

doi:10.1159/000330246

Cited by 27 publications

(15 citation statements)

References 28 publications

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“…And yet their body weight status (mean BMI = 27.9 kg/m 2 , obesity prevalence = 32.7%) was similar to that of the 4 inactive US cohorts (74). Unfortunately, despite the fact that the PA levels of the abovementioned Spanish cohort was relatively high compared to current guidelines, this was not accompanied by a ‘healthy’ cardiometabolic profile.…”

Section: Cancer Survivors Do Not Take Full Advantage Of the Pa Andmentioning

confidence: 72%

Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis

Sanchís-Gomar

Lucía

Yvert

et al. 2015

Cancer Prevention Research

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Sedentary lifestyle is associated with elevated cancer risk whereas regular physical activity (PA) and high cardiorespiratory fitness (CRF) have the opposite effect, with several biological mechanisms mediating such associations. There is a need for lifestyle interventions aimed at increasing the PA levels and CRF of the general population and particularly cancer survivors. Further, provocative data suggest a dose-dependent benefit of increasing levels of PA and/or CRF against cancer risk or mortality. Thus, current PA guidelines (≥150 min/week of moderate-to-vigorous PA) may not be sufficiently rigorous for preventing cancer nor for extending cancer survivorship. Research targeting this issue is urgently needed. Promoting regular PA along with monitoring indicators of CRF and adiposity may provide powerful strategies to prevent cancer in populations, help cancer patients more effectively deal with their disease and enhance secondary prevention programs in those who are affected by cancer.

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Section: Cancer Survivors Do Not Take Full Advantage Of the Pa Andmentioning

confidence: 72%

Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis

Sanchís-Gomar

Lucía

Yvert

et al. 2015

Cancer Prevention Research

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“…2,3 Patients suspected of having UTUC need to receive invasive procedures such as computed tomography (CT) urography, retrograde pyelography, or ureteroscopy for a definitive diagnosis. Many researchers have tried to develop useful urinary markers to detect UTUC, 4,5 but urine cytology still remains the only non-invasive diagnostic marker recommended by many guidelines 6,7 although its sensitivity for detection of UTUC is as low as 40%. 8 Cell-free DNA in bodily fluids has huge potential in disease diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic potential of TERT promoter and FGFR3 mutations in urinary cell‐free DNA in upper tract urothelial carcinoma

et al. 2019

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Most upper tract urothelial carcinomas ( UTUC ) are muscle invasive at the time of diagnosis. Current standard methods for the diagnosis of UTUC are invasive. Urine cytology is the only non‐invasive test for detecting UTUC , but its sensitivity is low. A novel non‐invasive assay for UTUC detection would improve patient outcome. This study aimed to investigate the mutation of cell‐free DNA (cf DNA ) in urine supernatant to develop a reliable diagnostic biomarker for UTUC patients. We studied urinary cf DNA from 153 individuals, including 56 patients with localized UTUC , and carried out droplet digital PCR assay for TERT promoter and FGFR 3 hotspot mutations. We could detect mutations of TERT C228T in 22/56 (39.3%), TERT C250T in 4/56 (7.1%), and FGFR 3 S249C in 9/56 (16.1%) patients. FGFR 3 mutation was detected only in ≤ pT 1 tumors (positive predictive value: 100.0%). In combination with cytology results, the sensitivity was 78.6%, and the specificity was 96.0%. Although these data need to be validated in a larger‐scale cohort, mutation analysis of TERT promoter and FGFR 3 in urinary cf DNA has the potential to be a non‐invasive diagnostic marker and reliable factor for tumor staging.

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“…Several studies have discussed the relevance of urine markers to detect UUT UC [ 3 , 5 , 6 ]. Still, urine cytology is the only marker, which is recommended by current guidelines, even if it is known to be less sensitive for the detection of UUT UC compared to UC of the bladder [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

et al. 2018

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Objectives To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). Patients and Methods The study comprised 758 urine samples either collected from the bladder (n = 373) or UUT (n = 385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed. Results UUT UC was diagnosed in 59 patients (19.1%) (UUT urine) and 27 patients (7.2%) (bladder-derived urine). For UUT-derived samples, sensitivities for cytology, FISH, NMP22, and uCyt+ were 74.6, 79.0, 100.0, and 100.0, while specificities were 66.6, 50.7, 5.9, and 66.7%, respectively. In bladder-derived samples, sensitivities were 59.3, 52.9, 62.5, and 50.0% whereas specificities were 82.9, 85.0, 31.3, and 69.8%. In UUT-derived samples, concomitant bladder cancer led to increased false-positive rates of cytology and FISH. Conclusions Urine markers determined in urine collected from the UUT exhibit better sensitivity but lower specificity compared to markers determined in bladder-derived urine. Concomitant or recent diagnosis of UC of the bladder can further influence markers determined in UUT urine.

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Diagnostic Value of the Nuclear Matrix Protein 22 Test and Urine Cytology in Upper Tract Urothelial Tumors

Cited by 27 publications

References 28 publications

Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis

Physical Inactivity and Low Fitness Deserve More Attention to Alter Cancer Risk and Prognosis

Diagnostic potential of TERT promoter and FGFR3 mutations in urinary cell‐free DNA in upper tract urothelial carcinoma

Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

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