Diagnostic value of the neutrophil lymphocyte ratio in discrimination between tuberculosis and bacterial community acquired pneumonia: A meta-analysis

Shojaan, Horieh; Kalami, Niusha; Ghasempour Alamdari, Masoumeh; Emami Alorizy, Seyed Matin; Ghaedi, Arshin; Bazrgar, Aida; Khanzadeh, Monireh; Lucke-Wold, Brandon; Khanzadeh, Shokoufeh

doi:10.1016/j.jctube.2023.100395

Cited by 6 publications

(3 citation statements)

References 71 publications

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“…The pre-treatment NLR upon admission could serve as a valuable biomarker for predicting mortality and the onset of acute respiratory distress syndrome in individuals with miliary tuberculosis [103]. A recent meta-analysis has shown that NLR has a reliable power to discriminate between PTB infection and bacterial community acquired pneumonia-the lower the NLR, the higher the chances of PTB infection [104]. Our study has not showed significant differences in NLR between the two groups.…”

Section: Discussioncontrasting

confidence: 45%

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Mihuta,

Socaci,

Hogea

et al. 2024

Medicina

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Background and Objectives: The concurrent occurrence of tuberculosis and COVID-19 coinfection poses significant clinical complexities, warranting a nuanced approach to diagnosis, management, and patient care. Materials and Methods: A retrospective, cross-sectional study was conducted on two groups: one comprising 32 patients with pulmonary TB (PTB) and COVID-19 co-infection, and one including 100 patients with COVID-19 alone. Data was collected from medical records, including patient history, clinical parameters, laboratory, imaging results, and patient outcome. Results: A lower BMI emerges as a significant marker suggesting underlying PTB in patients with SARS-CoV-2 co-infection. Type 2 diabetes mellitus increases the risk of death in PTB-SARS-CoV-2 co-infection. Co-infected patients show lymphocytopenia and higher neutrophil levels, CRP, transaminases, and D-dimer levels. Elevated CRP and ALT levels are linked to increased co-infection likelihood. Certain parameters like SpO2, CRP, ALT, AST, and D-dimer effectively differentiate between co-infected and COVID-19 patients. Platelet-to-lymphocyte ratio is notably higher in co-infected individuals. Lesion severity on imaging is significantly associated with co-infection, highlighting imaging’s diagnostic importance. Longer hospital stays are linked to co-infection but not significantly to death risk. Conclusions: Certain clinical and biological factors may serve as potential indicators of PTB co-infection in patients with SARS-CoV-2.

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Section: Discussioncontrasting

confidence: 45%

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Mihuta,

Socaci,

Hogea

et al. 2024

Medicina

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Section: Introductionmentioning

confidence: 99%

“…7 Recent studies have proposed a potential association between elevated RDW levels and systemic inflammation, implicating its utility as an adjunctive marker for disease activity in various medical conditions including cardiovascular diseases, malignancies, and inflammatory disorders. 8,9 In the context of rheumatic diseases, the concept of RDW as an inexpensive and easily accessible marker for disease activity holds promise. 10 A growing body of research has begun to explore the relationship between RDW and diseaseactivity indices specific to rheumatic conditions.…”

Section: Introductionmentioning

confidence: 99%

Red Blood Cell Distribution Width: A Potential Inexpensive Marker for Disease Activity in Patients with Rheumatic Diseases; Scoping Review

Alghamdi

2023

OARRR

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Background Rheumatic diseases encompass a diverse group of autoimmune disorders that affect the joints and connective tissues. The red blood cell distribution width (RDW) has been widely investigated as an inflammatory marker. This scoping review aimed to explore the potential utility of RDW as an inexpensive marker for disease activity in patients with rheumatic diseases. By summarizing the available evidence, we aimed to determine whether RDW can serve as a reliable and accessible indicator of disease activity in these patients. Methods A comprehensive search was systematically performed across electronic databases, encompassing PubMed, Embase, and Web of Science. Studies have explored the relationship between RDW and disease activity in rheumatic diseases. Data extraction focused on the study characteristics, methodologies, and findings related to RDW as a disease activity marker. Results After removing duplicates, the initial search yielded 25 relevant studies. These studies encompassed a variety of rheumatic diseases, with rheumatoid arthritis being the most frequently studied condition. The association between RDW and disease activity was assessed by using various disease activity indices and clinical parameters. While some studies have reported a significant correlation between elevated RDW and disease activity, others have yielded inconclusive results. Conclusion From this review, we concluded that RDW is an inexpensive potential marker for the evaluation of disease activity in rheumatic diseases. RDW is promising as an inexpensive and readily available marker; however, its clinical utility in assessing disease activity in rheumatic conditions warrants more rigorous investigation through well-designed prospective studies.

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Biomarkers in diagnosing and therapeutic monitoring of tuberculosis: a review

Leo,

Narasimhan,

Rathinam

et al. 2024

Annals of Medicine

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Tuberculosis (TB) continues to pose a significant health challenge worldwide, emphasizing the importance of prompt diagnosis and efficient monitoring of treatment outcomes for effective disease control. Biomarkers have become increasingly important in the realm of TB diagnoses and treatment. The objective of this comprehensive review is to examine the present state of biomarkers employed in the diagnosis of TB, monitoring the response to treatment, and predicting treatment outcomes. In this study, we undertake a comprehensive examination of the diverse biomarkers utilized in TB diagnoses, spanning molecular, immunological, and other novel methodologies. Furthermore, we examine the potential of biomarkers in the context of therapeutic monitoring, assessment of treatment effectiveness, and anticipation of drug resistance. Additionally, this paper presents future prospects regarding the utilization of biomarkers in the therapy of tuberculosis.

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Diagnostic value of the neutrophil lymphocyte ratio in discrimination between tuberculosis and bacterial community acquired pneumonia: A meta-analysis

Cited by 6 publications

References 71 publications

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Colliding Challenges: An Analysis of SARS-CoV-2 Infection in Patients with Pulmonary Tuberculosis versus SARS-CoV-2 Infection Alone

Red Blood Cell Distribution Width: A Potential Inexpensive Marker for Disease Activity in Patients with Rheumatic Diseases; Scoping Review

Biomarkers in diagnosing and therapeutic monitoring of tuberculosis: a review

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