2008
DOI: 10.1080/08860220802359048
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Diagnostic Value of the Aminopeptidase N, N-Acetyl-β-D-Glucosaminidase and Dipeptidylpeptidase IV in Evaluating Tubular Dysfunction in Patients with Glomerulopathies

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Cited by 39 publications
(26 citation statements)
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“…Interestingly, Wang and coworkers (Wang et al 2014) found that rat kidney extracts showed the highest DPP-4 activity; however, plasma DPP-4 activity did not decrease after kidney transplantation from a DPP-4-deficient rat into a wild-type one indicating that the kidney is not the main source of soluble DPP-4 under normal healthy conditions. In addition, it was reported that urinary DPP-4 activity was significantly higher in type 2 diabetic patients with microalbuminuria, an early sign of diabetic nephropathy, compared to healthy individuals (Mitic et al 2008). These observations highlight a potential role of DPP-4 in the development of diabetic nephropathy (von Websky et al 2014).…”
Section: Discovery Molecular Biology and Renal Expression Of Dpp-4mentioning
confidence: 73%
“…Interestingly, Wang and coworkers (Wang et al 2014) found that rat kidney extracts showed the highest DPP-4 activity; however, plasma DPP-4 activity did not decrease after kidney transplantation from a DPP-4-deficient rat into a wild-type one indicating that the kidney is not the main source of soluble DPP-4 under normal healthy conditions. In addition, it was reported that urinary DPP-4 activity was significantly higher in type 2 diabetic patients with microalbuminuria, an early sign of diabetic nephropathy, compared to healthy individuals (Mitic et al 2008). These observations highlight a potential role of DPP-4 in the development of diabetic nephropathy (von Websky et al 2014).…”
Section: Discovery Molecular Biology and Renal Expression Of Dpp-4mentioning
confidence: 73%
“…DPP IV activity increases in the urine of patients with diabetes, especially those with microalbuminuria (Golubović et al, 1996;Mitic et al, 2008). These findings indicate that the change of DPP IV in urine is probably associated with diabetic nephropathy.…”
Section: Introductionmentioning
confidence: 83%
“…Increased DPP IV activity in the kidney or urine is a well recognized hallmark of diabetic patients and animals with renal dysfunction, which is probably an important sign or booster of the progression of diabetic nephropathy (Golubović et al, 1996;Yang et al, 2007;Mitic et al, 2008). In addition, patients with diabetes mellitus show dramatic loss of GLP-1 potency (Hojbjerg et al, 2007;Holst et al, 2009).…”
Section: Discussionmentioning
confidence: 99%
“…[18][19][20] In addition to its role in T-cell biology, DPP IV also plays an important role in the pathogenesis of kidney diseases such as IgA nephropathy. 21 We here studied the excretion of DPP IV in urinary microvesicles in a small cohort of patients with T2DM by categorising them into three groups according to the severity of kidney damage. In this study, we first assessed the feasibility of using urine as a microvesicle source in the context of a clinical trial, and then investigated the changes in urinary microvesicle-DPP IV levels during different stages of DKD.…”
Section: Discussionmentioning
confidence: 99%