Diagnostic value of ¹²³Iodine scintigraphy and perchlorate discharge test in the diagnosis of congenital hypothyroidism

Abstract

This findings suggest that scintigraphy is indispensible in the correct diagnostic work up of congenital hypothyroidism.

Clinical Description of Infants with Congenital Hypothyroidism and Iodide Organification Defects

“…In conclusion, scintigraphy combined with perchlorate discharge testing is useful for diagnosing CH with normal thyroid-gland position, in keeping with earlier data [39], but fails to suggest the underlying molecular mechanism. We found phenotypic differences between patients with TIOD and those with PIOD.…”

Diagnostic spectrum of congenital hypothyroidism in Turkish children

“…Thyroid scintigraphy is currently the most precise diagnostic technique used to determine the etiology of CH and therefore should be considered as the first choice in infants with high TSH levels 1 . Perchlorate discharge test is used in differential diagnosis of dyshormonogenesis 4 . Grayscale ultrasonography (GSU) is a sensitive method for evaluating the anatomy of the thyroid gland.…”

Untitled

“…12 Fructosamine levels significantly increased in hypothyroidism, subclinical hypothyroidism and lowered in hyperthyroidism group as compared to normal group. A Significant correlation was found between T3, T4, TSH and fructosamine levels in hyperthyroid patient.…”

“…10,11 Similarly our study correlate with Meller, Fagila and Rangaswamy fructosamine values significantly increased in hypothyroidism, subclinical hypothyroidism and lowered in hyperthyroidism group compared to normal group. 12,13,14 Significant correlation was found between T3, T4, TSH and fructosamine levels. It was concluded that serum fructosamine as useful the diagnostic indicator in patients with thyroid diseases.…”