Diagnostic value of soluble biomarkers for parapneumonic pleural effusion

Cao, Xi‐Shan; Zheng, Wen‐Qi; Hu, Zhide

doi:10.1080/10408363.2022.2158779

Cited by 2 publications

(1 citation statement)

References 162 publications

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“…In some patients, MPE was defined as the presence of a primary or metastatic tumor, and BPE can be excluded by their clinical characteristics and treatment response. Parapneumonic effusion (PPE) was diagnosed based on imaging, microbiology, biopsy, and response to antibiotic treatment [ 22 ]. TPE was diagnosed based on biopsy, Mycobacterium tuberculosis (Mtb) culture, Ziehl-Neelsen staining, and response to anti-tuberculosis therapy.…”

Section: Methodsmentioning

confidence: 99%

Age affects the diagnostic accuracy of the cancer ratio for malignant pleural effusion

Huang¹,

Chen²,

Gu³

et al. 2023

BMC Pulm Med

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Background and objective Cancer ratio (CR), which is defined as serum lactate dehydrogenase (LDH) to pleural fluid adenosine deaminase (ADA) ratio, has been reported to be a useful diagnostic marker for malignant pleural effusion (MPE). Whether its diagnostic accuracy is affected by age remains unknown. This study aimed to investigate the effects of age on the diagnostic accuracy of CR. Methods The participants in this study were from a prospective cohort (SIMPLE cohort, n = 199) and a retrospective cohort (BUFF cohort, n = 158). All participants were patients with undiagnosed pleural effusion (PE). We used receiver operating characteristic (ROC) curves to evaluate the diagnostic accuracy of CR. The effect of age on the diagnostic accuracy of CR was investigated by adjusting the upper limit of age for participant enrolment. Results Eighty-eight MPE patients were verified in the SIMPLE cohort, and thirty-five MPE patients were verified in the BUFF cohort. The AUCs of CR in the SIMPLE and BUFF cohorts were 0.60 (95% CI: 0.52–0.68) and 0.63 (95% CI: 0.54–0.71), respectively. In both cohorts, the AUCs of CR decreased with the advancement of age. Conclusion Age can affect the diagnostic accuracy of CR for MPE. CR has limited diagnostic value in older patients. Key message Cancer ratio is a promising diagnostic marker for malignant pleural effusion. This study revealed that its diagnostic accuracy decreased in older patients. Its diagnostic accuracy is overestimated by previous studies using tuberculosis and pneumonia patients as controls.

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Section: Methodsmentioning

confidence: 99%