Diagnostic value of serum type IV collagen test in comparison with platelet count for predicting the fibrotic stage in patients with chronic hepatitis C

Murawaki, Yoshikazu; Koda, Masahiko; Okamoto, Kinnya; Mimura, K.; Kawasaki, Hironaka

doi:10.1046/j.1440-1746.2001.02515.x

Cited by 76 publications

(49 citation statements)

References 26 publications

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“…Serum C-IV has been used to diagnose liver fibrosis in diseases that evolved with sinusoid capilarisation (Hiramatsu et al 1995, Murawaki et al 2001, pereira et al 2004, Santos et al 2005, Halfon et al 2006, Yoneda et al 2007). Comparing serum C-IV levels between groups, according to the clinical classification of patients with mansonic and hematobic schistosomiasis, Shahin et al (1992) found high serum levels in patients with hepatosplenic schistosomiasis.…”

Section: Discussionmentioning

confidence: 99%

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Marinho¹,

Bretas

Voieta³

et al. 2010

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Marinho¹,

Bretas

Voieta³

et al. 2010

Mem. Inst. Oswaldo Cruz

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“…Vários estudos têm utilizado o AH como preditor de fibrose nos pacientes com HCC (7,12,13,15,27) . Nossos achados corroboram os de Halfon et al (7) , que reuniram 405 portadores de HCC para avaliar a acurácia desse marcador em predizer o estádio da fibrose hepática, e concluíram que o AH poderia ser usado clinicamente como marcador não-invasivo para fibrose e/ou cirrose.…”

Section: Discussionunclassified

Valor preditivo de marcadores séricos de fibrose hepática em pacientes portadores de hepatite crônica viral C

Lima¹,

Martins

Nader

et al. 2008

J. Bras. Patol. Med. Lab.

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Introdução: Os marcadores séricos têm sido empregados na avaliação da fibrose hepática em pacientes portadores de hepatite crônica C (HCC). Objetivos: Avaliar a capacidade do índice aspartato aminotransferase (AST)/alanina aminotransferase (ALT), dos níveis séricos de gama-glutamiltransferase (GGT), contagem de plaquetas, do índice AST/plaquetas (APRI) e do ácido hialurônico (AH) em predizer a intensidade da fibrose hepática na HCC e a variação desses marcadores após tratamento com interferon. Pacientes e métodos: Em 72 pacientes portadores de hepatite C determinamos no soro o índice AST/ALT, GGT, plaquetas, índice APRI (obtido pelo quociente AST/plaquetas) e o AH, que foram comparados ao estadiamento histológico, segundo os critérios de METAVIR. Receberam tratamento com interferon e ribavirina 65 pacientes. Os indivíduos que concluíram o tratamento (n = 33) realizaram nova dosagem dos marcadores séricos de fibrose para comparar com os níveis pré-tratamento. Resultados: Observamos que a GGT, a contagem de plaquetas, o índice APRI e o AH se correlacionaram com estádio de doença hepática (p < 0,01), exceto o índice AST/ALT. A análise das áreas sob as curvas ROC (AUC) evidenciaram que a melhor associação com estadiamento hepático foi para o índice APRI e a dosagem sérica do AH: AUC (APRI) = 0,85 e AUC (AH) = 0,86. Na avaliação pós-terapia com interferon, apenas a GGT e o índice APRI apresentaram redução de seus níveis (p < 0,05). Conclusão: O AH e o índice APRI apresentaram maior acurácia no estadiamento da fibrose, podendo ser aplicados como métodos diagnósticos alternativos na HCC. abstract resumo Introduction: Serum markers have been used in the assessment of liver fibrosis in patients with chronic hepatitis C (CHC). Aims: We evaluated the capacity of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, gama-glutamyltransferase (GGT) levels, platelet count, the AST to platelet ratio index (APRI) and serum hyaluronic acid (HA) to predict the intensity of hepatic fibrosis in patients with CHC and the variation of these markers after therapy with interferon. Patients and methods: In 72 patients with hepatitis C, AST/ALT ratio, GGT levels, platelet count, the APRI index (calculated as the ratio of AST to platelets) and

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“…These include: glycoproteins, such as serum hyaluronate [13][14][15][16][17], laminin [18,19], and YKL-40 [20]; the collagens family, such as procollagen III N-peptide (PIIINP) [13] and type IV collagen [21]; collagenases and their inhibitors, such as matrix metalloproteases (MMP) [22] and tissue inhibitory metalloprotease-1 (TIMP-1) [23].…”

Section: Biological Approach: Serum Fibrosis Biomarkersmentioning

confidence: 99%

Non-invasive assessment of liver fibrosis in chronic hepatitis C

Castéra

2011

Hepatol Int

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Diagnostic value of serum type IV collagen test in comparison with platelet count for predicting the fibrotic stage in patients with chronic hepatitis C

Abstract: The serum type IV collagen test was slightly superior to the platelet count for assessing the fibrotic stage in patients with chronic hepatitis C.

Cited by 76 publications

References 26 publications

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Serum hyaluronan and collagen IV as non-invasive markers of liver fibrosis in patients from an endemic area for schistosomiasis mansoni: a field-based study in Brazil

Valor preditivo de marcadores séricos de fibrose hepática em pacientes portadores de hepatite crônica viral C

Non-invasive assessment of liver fibrosis in chronic hepatitis C

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