Diagnostic Value of Serum Procalcitonin in Patients with Convulsion in Emergency Department, an Observational Study

Murakami, Hisashi; Naraba, Hiromu; Gondo, Takashi; Mochizuki, Masaki; Nakano, Hidehiko; Takahashi, Yūji; Sonoo, Tomohiro; Hashimoto, Hideki; Nakamura, Kensuke

doi:10.3390/antibiotics9100683

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…Similarly, procalcitonin levels (PCT) were higher in cases than in controls, with median PCT levels of 0.29 ng/ml in cases ag/ml in controls. A similar finding was found by Murakami et al ( 36 ) who found increased levels of PCT in convulsion patients. Increased levels of procalcitonin were first observed in 1993 in patients with sepsis, and today it is a widely used biomarker for serious bacterial infections ( 37 ).…”

Section: Discussionsupporting

confidence: 90%

Pediatric infection with the Omicron variant increases the risks of febrile seizures among COVID-19 infected children

Mohamed,

Tang,

Thokerunga

et al. 2023

Front. Pediatr.

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BackgroundThe Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is less likely to cause severe disease in children than the other variants but has become an increasing cause of febrile seizures (FS) among children. In this case-control study, we aimed to examine the risk factors associated with FS in children infected with the COVID-19 Omicron variant and related treatment modalities.MethodsThis retrospective case-control study includes 113 subjects infected with the COVID-19 Omicron variant, grouped into 45 cases (those with FS) and 68 controls (those without FS). Data on clinical features, laboratory parameters, and treatment modalities were collected and analyzed.ResultsApproximately 5.74% of COVID-19 infected children developed COVID-19-associated FS. Children with COVID-19 and high body temperatures [RR 1.474; (95% CI: 1.196–1.818), p < 0.001], previous history of FS [RR 1.421; (95% CI: 1.088–1.855), p = 0.010], high procalcitonin levels [RR 1.140; (95% CI: 1.043–1.246), p = 0.048] and high neutrophil counts [RR 1.015; (95% CI: 1.000–1.029), p = 0.048] were more likely to experience FS than the controls. In contrast, children with COVID-19 and low eosinophil counts, low hemoglobin levels, and cough had a lower risk of developing FS [RR 0.494; (95% CI: 0.311–0.783), p = 0.003], [RR 0.979; (95% CI: 0.959–0.999), p = 0.044]; and [RR 0.473 (95% CI 0.252–0.890), p = 0.020]; respectively. Children with FS received more anti-flu medications than those without.ConclusionA significant increase in FS was observed in children with Omicron SARS-CoV-2 infection. A higher body temperature, a history of FS, a higher procalcitonin level, and a high neutrophil count were all associated with an increased risk of FS in children with COVID-19. The risk of developing FS was lower in children with COVID-19 and low eosinophil counts and hemoglobin levels than in those without.

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Section: Discussionsupporting

confidence: 90%

Pediatric infection with the Omicron variant increases the risks of febrile seizures among COVID-19 infected children

Mohamed,

Tang,

Thokerunga

et al. 2023

Front. Pediatr.

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“…Procalcitonin was initially elevated, but it improved over the course of a few days. Of note, elevated procalcitonin has been previously reported in the setting of convulsions [7]. Similarly, the elevated lactate levels returned to the normal range following intravenous hydration.…”

Section: Hours Of Admissionsupporting

confidence: 55%

Prolonged Seizure Activity Followed by Severe Hyperphosphatemia and Hypocalcemia in a Pediatric Patient

Coriell¹,

Hersh²,

Shah³

2021

Cureus

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Seizures secondary to hypocalcemia have been well documented and studied. There are various causes of hypocalcemia described in the literature, but a prolonged seizure episode leading to cell lysis, severe hyperphosphatemia, and hypocalcemia is rarely reported. We present the case of a 3-year-old male with severe hyperphosphatemia and hypocalcemia secondary to the likely presence of cell lysis from prolonged seizure activity. Our case illustrates the importance of a thorough evaluation of the possible differentials of hypocalcemia and hyperphosphatemia in a challenging presentation.

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“… 10 However, high procalcitonin levels have been reported in patients with seizures. 11 The seizure induced by ECT lasted briefly, but may have been the cause of the increase in serum procalcitonin level in our patient.…”

Section: Discussionmentioning

confidence: 59%

“…In general, procalcitonin is recognized as a useful and highly sensitive marker of bacterial infections 10 . However, high procalcitonin levels have been reported in patients with seizures 11 . The seizure induced by ECT lasted briefly, but may have been the cause of the increase in serum procalcitonin level in our patient.…”

Section: Discussionmentioning

confidence: 59%

A case of negative‐pressure pulmonary oedema after first‐time electroconvulsive therapy

Sekimoto

Suzuki

Kanamori

et al. 2022

Respirology Case Reports

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Electroconvulsive therapy (ECT) has been used for many years as an important treatment modality in patients with schizophrenia. Recently, many new oral medications have become available to treat schizophrenia. However, ECT remains a valuable therapy for patients who are resistant to oral medications. A 16‐year‐old girl with schizophrenia was admitted to our hospital with hypoxaemia due to negative‐pressure pulmonary oedema (NPPE) after her first ECT. NPPE is an exceedingly rare complication after ECT. However, it can result in serious morbidity if not immediately recognized and treated. This case illustrates the importance of recognizing this rare complication.

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Diagnostic Value of Serum Procalcitonin in Patients with Convulsion in Emergency Department, an Observational Study

Cited by 4 publications

References 17 publications

Pediatric infection with the Omicron variant increases the risks of febrile seizures among COVID-19 infected children

Pediatric infection with the Omicron variant increases the risks of febrile seizures among COVID-19 infected children

Prolonged Seizure Activity Followed by Severe Hyperphosphatemia and Hypocalcemia in a Pediatric Patient

A case of negative‐pressure pulmonary oedema after first‐time electroconvulsive therapy

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