Diagnostic Value of Serum Procalcitonin in Early Infection after Internal Fixation for Traumatic Fracture

Zhao, Quanming; Zhu, Haoming; Hong, Shang-Chao; Li, Cheng

doi:10.7754/clin.lab.2017.170601

Cited by 5 publications

(3 citation statements)

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“…The study was conducted on a large, well defined, nationwide cohort of COPD patients with complete data available on prescription of medication and hospital admissions [17][18][19][20].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Depressive symptoms among patients with COPD according to smoking status: a Danish nationwide case�control study of 21 184 patients

et al. 2020

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IntroductionDepressive symptoms appear more often among patients with chronic obstructive pulmonary disease (COPD) and are associated with reduced disease control and increased mortality. Both smoking and COPD increase the risk of depressive symptoms. Whether smoking cessation among COPD patients affects the occurrence of depressive symptoms is unknown. We hypothesised that smoking cessation in patients with COPD leads to reduced use of antidepressants and fewer admissions to psychiatric hospitals with depression, anxiety or bipolar disorder.MethodsWe conducted a nationwide retrospective case-control study, in patients from The Danish Register for Chronic Obstructive Pulmonary Disease (DrCOPD) with spirometry verified COPD, age ≥40 years, a history of smoking and absence of cancer. Consistent smokers were matched 1:1 with ex-smokers using a propensity score model. Prescription fillings of antidepressants and risk of admissions to psychiatric hospitals with either depression, anxiety or bipolar disorder both descriptively was assessed by Cox proportional hazard models.ResultsWe included 21 184 patients. A total of n=2011 consistent smokers collected antidepressant prescriptions compared with 1821 ex-smokers. Consistent smoking was associated with increased risk of filling prescription on antidepressants (HR 1.4, 95% CI 1.3–1.5, p<0.0001). and with increased risk of psychiatric hospital admission with either depression, anxiety or bipolar disorder (HR 2.0, 95% CI 1.6–2.5). The associations persisted after adjustment for former use of antidepressants.ConclusionConsistent smoking among COPD patients was associated with increased use of antidepressants and admissions to psychiatric hospitals with either depression, anxiety or bipolar disorder, compared to smoking cessation.

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“…The study was conducted on a large, well defined, nationwide cohort of COPD patients with complete data available on prescription of medication and hospital admissions [17][18][19][20].…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Depressive symptoms among patients with COPD according to smoking status: a Danish nationwide case�control study of 21 184 patients

et al. 2020

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“…In short, when preoperative ESR and CRP level are abnormally elevated, their diagnostic value is limited [ 22 ]. The value of PCT combined with CRP in the detection of early postoperative infection is higher than that of CRP when tested alone [ 23 ]. Therefore, we can use CRP and ESR combined with PCT to improve the diagnostic sensitivity for infection after IF.…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Infection Factors in Secondary Internal Fixation after External Fixation for Open Fracture of a Long Bone: A Cohort of 117 Patients in a Two-Center Clinical Study

Zhao

Zeng

et al. 2022

BioMed Research International

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Purpose. To investigate infection risk factors after secondary internal fixation (IF) of open fracture of a long bone with removed fixation frame and explore the safe range of feasible operation for abnormal inflammatory indicators. Methods. Clinical data of 117 cases of open fracture of a long bone that underwent temporary external fixation (EF) in one stage and IF in two stages were retrospectively analyzed. Collected data included age, sex, Gustilo type, multiple injuries, debridement time, duration of EF, needle infection, interval of conversion to IF after external fixator, preoperative white blood cell (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), albumin (ALB), blood glucose, and prognosis. We selected these factors for univariate analysis of postoperative surgical site infection (SSI) and multivariate logistic regression analysis of statistically significant risk factors and created receiver operating characteristic (ROC) curves to compare the diagnostic efficiency of each index and determine the optimal screening point. Results. We followed up 117 patients, with 130 limbs affected. Univariate analysis showed that ESR, CRP, ALB, WBC, EF time, and Gustilo fracture type were significantly associated with SSI. Multivariate logistic regression analysis showed that CRP, duration of EF, and Gustilo fracture type were independently associated with postoperative infection. Area under ROC curves for WBC, ESR, and CRP were 69.7%, 73.2%, and 81.2%. Conclusions. We demonstrated the role of Gustilo classification of open fractures in predicting postoperative infection, especially for open fractures above type III. If the inflammatory indexes return to normal or show a downward trend, and the second-stage IF operation is performed within the cutoff values, postoperative recurrent infection was reduced.

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“…A meta-analysis, performed by Vouloumanou et al, 7 suggests that PCT has great diagnostic value after the first 48 h of life. Meanwhile, Zhao et al 8 found that PCT was useful for the early diagnosis of severe infection but had limited value in the diagnosis of mild infection. CRP is an acute, time-phase protein that begins to rise 4–6 h after bacterial infection and usually reaches an effective threshold after 24–48 h. However, CRP fluctuates greatly in the first 3 days after birth, so errors arise in the diagnosis of neonatal infection based on CRP alone.…”

Section: Introductionmentioning

confidence: 99%

An Analysis of Predictive Factors for Severe Neonatal Infection and the Construction of a Prediction Model

Wang¹,

Wang²,

Li³

2023

IDR

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Objective To investigate the primary predictive factors for the occurrence of severe neonatal infection, construct a prediction model and assess its effectiveness. Methods A total of 160 neonates hospitalised in the Department of Neonatology at Suixi County Hospital from January 2019 to June 2022 were retrospectively analysed. Clinical data was analyzed to determine the primary predictive factors for the occurrence of severe neonatal infection. Predictive efficacy was evaluated using a receiver operating characteristic curve, and a nomogram model was constructed according to the predictors. A bootstrap technique was used to verify the accuracy of the model. Results The neonates were divided, based on the degree of infection, into a mild infection group (n = 80) and a severe infection group (n = 80) according to a 1:1 ratio. Multivariate logistic regression analysis showed that compared with the recovery stage, white blood cell count (WBC) and platelet count (PLT) in the two groups were significantly decreased in the early stage of infection, and the ratio of mean platelet volume to PLT, as well as C-reactive protein (CRP) and procalcitonin levels, was elevated (P < 0.05). The area under the curves (AUCs) of decreased WBC, decreased PLT and elevated CRP levels, and the combination of these three indicators, were 0.881, 0.798, 0.523 and 0.914, respectively. According to the filtered indicators, two models (a dichotomous variable equation model and a nomogram model) of continuous numerical variables were constructed, and their AUCs were 0.958 and 0.914, respectively. The calibration curve of the nomogram model was validated with a consistency index of 0.908 (95% confidence interval [0.862, 0.954]). Conclusion Decreased WBC and PLT levels and an elevated CRP level were the primary independent predictors of severe neonatal infection.

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Diagnostic Value of Serum Procalcitonin in Early Infection after Internal Fixation for Traumatic Fracture

Abstract: The serum PCT level can be used as an early diagnostic indicator of infection after internal fixation for traumatic fracture. The combined use of PCR and CRP levels can increase the sensitivity of detection.

Cited by 5 publications

References 0 publications

Depressive symptoms among patients with COPD according to smoking status: a Danish nationwide case�control study of 21 184 patients

Depressive symptoms among patients with COPD according to smoking status: a Danish nationwide case�control study of 21 184 patients

Retrospective Analysis of Infection Factors in Secondary Internal Fixation after External Fixation for Open Fracture of a Long Bone: A Cohort of 117 Patients in a Two-Center Clinical Study

An Analysis of Predictive Factors for Severe Neonatal Infection and the Construction of a Prediction Model

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