Diagnostic Value of Serum Procalcitonin in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis

Yu, Xin; Wang, Y.; Zhong, Haining; Dou, Qingli; Song, Yijun; Wen, Hao

doi:10.1016/j.transproceed.2013.07.074

Cited by 39 publications

(28 citation statements)

References 23 publications

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“…Meta-analysis demonstrated that the procalcitonin cut-off value was 6.12 (3.79-9.88). The sensitivity and specificity of procalcitonin were 90% and 85%, respectively (21).…”

Section: Discussionmentioning

confidence: 97%

Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection

Gür¹,

Oğuztürk

Kose

et al. 2017

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“…Meta-analysis demonstrated that the procalcitonin cut-off value was 6.12 (3.79-9.88). The sensitivity and specificity of procalcitonin were 90% and 85%, respectively (21).…”

Section: Discussionmentioning

confidence: 97%

Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection

Gür¹,

Oğuztürk

Kose

et al. 2017

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“…However, none of these biomarkers has shown a satisfactory accuracy to justify a change in present practice. 6 Of the novel biomarkers, procalcitonin seems to be the most promising. It has been demonstrated that serum levels of procalcitonin are superior over other biomarkers in diagnosing systemic infection in both normal and immunocompromised populations.…”

Section: Discussionmentioning

confidence: 99%

“…However, in cases with suspected acute rejection, a low procalcitonin value may provide evidence to rule out the presence of superimposed bacterial infection. 6 In a recent meta-analysis, the role of procalcitonin as a potential biomarker for use in identifying infectious complications after transplant was analyzed. A sensitivity of 85% and a specificity of 81% were reported for procalcitonin in identifying bacterial infection after transplant.…”

Section: Discussionmentioning

confidence: 99%

“…5 In SOT recipients, many factors like surgical trauma, organ damage, and use of immuno suppressive agents may lead to an increase in serum procalcitonin levels but to a lesser degree than that shown with bacterial infections. 6 Although use of serum procalcitonin levels has increased over time, we still do not have enough experience and study data in SOT recipients. In this study, we aimed to evaluate the role of procalcitonin in identifying infectious complications in SOT recipients.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2016

Exp Clin Transplant

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Objectives: Systemic infection is among the common complications after solid-organ transplant and is associated with increased mortality and morbidity. Because it has prognostic significance, timely diagnosis and treatment are crucial. Procalcitonin is a propeptide of calcitonin and has been increasingly used as a biomarker of bacterial infection. Here, we investigated procalcitonin's role in identifying infectious complications in solid-organ transplant recipients. Materials and Methods: We retrospectively evaluated the records of 86 adult patients who underwent solidorgan transplant (between 2011 and 2015) with procalcitonin levels determined at our center. Clinical and demographic variables and laboratory data were noted. Relation between C-reactive protein and procalcitonin serum levels were compared in patients who were diagnosed as having pneumonia on clinical, microbiologic, and radiologic findings. Results: Mean age of our patients was 45.5 ± 13.4 years (range, 18-70 y), with 61 male patients (70.9%). We included 26 liver, 44 kidney, 14 heart, and 2 heart and renal transplant recipients. Procalcitonin was positive in 43 patients (50%). Of the 39 patients who were diagnosed with pneumonia, procalcitonin was positive in 18 patients (46.2%). There was a significant correlation between serum levels of procalcitonin and C-reactive protein (r = 0.45; P < .001) and neutrophil count (r = 0.24; P = .025). There was no correlation between mortality and procalcitonin level, CRP level, or leukocyte count (P > .05). Conclusions: Our findings indicate that procalcitonin is a promising biomarker to detect infectious complications in transplant recipients. Physical examination and radiologic findings of bacterial pneumonia may be nonspecific, and in a considerable number of immunocompromised patients the site of infection could not be identified. Serum levels of procalcitonin should not be used as sole criteria for clinical decision making; however, it can guide us in therapy of such conditions in addition to currently used serum markers of infection.

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“…One possible explanation might be that CRP is in general produced in the liver and that CRP production can be delayed in the graft, especially when the graft shows delayed or primary non-function. In contrast, PCT is produced in C cells of the thyroid gland and by neuroendocrine cells of the lung and the intestine [12,13]. However, PCT is more a marker for bacterial than for viral infections [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation

Helfritz¹,

Lehner²,

Mp³

2015

J Hepatol Gastroint Dis

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Diagnostic Value of Serum Procalcitonin in Solid Organ Transplant Recipients: A Systematic Review and Meta-analysis

Cited by 39 publications

References 23 publications

Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection

Prognostic Value of Procalcitonin, CRP, Serum Amyloid A, Lactate and IL-6 Markers in Liver Transplant Patients Admitted to ED with Suspected Infection

Untitled

Perioperative White Blood Cell Count as a Marker for Patient and Graft Survival after Orthotopic Liver Transplantation

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