Diagnostic value of serum human Galactomannan aspergillus antigen and 1,3‐beta‐D‐glucan in immunocompromised patient suspected fungal infection

Susianti, Hani; Parmadi, Lydiana; Firani, Novi Khila; Setyawan, Ungky Agus; Sartono, Teguh Rahayu

doi:10.1002/jcla.23806

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…In the study by Susianti et al, there were no significant differences in the total leucocyte count and neutrophil count in the fungal-infected group and nonfungal-infected group [ 16 ]. Our results are consistent with the literature in that there were no significant differences in GM I values among IA patients with and without neutropenia ( P > 0.05).…”

Section: Resultsmentioning

confidence: 99%

Performance of the Aspergillus galactomannan lateral flow assay with a digital reader for the diagnosis of invasive aspergillosis: a multicenter study

Guo,

Xiao,

Tian

et al. 2023

Eur J Clin Microbiol Infect Dis

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Purpose The objective of this multicenter study was to compare the diagnostic performance of lateral flow assay (LFA) and enzyme-linked immunosorbent assay (ELISA) to detect the Dynamiker Aspergillus Galactomannan levels in serum and bronchoalveolar lavage fluid (BALF) samples for I. Methods We registered 310 clinically suspected Aspergillus infection patients from December 2021 to February 2023 and classified them into subgroups as the “IA group” and “non-IA group” based on the latest EORTC/MSG guidelines. The immunoassays were analyzed by LFA and ELISA respectively. Results Galactomannan was examined using LFA, and serum and BALF samples demonstrated sensitivities of 82.57% and 89.47%, specificities of 90.76% and 92.00%, PPVs of 89.11% and 96.23%, and NPVs of 85.04% and 79.31%, respectively. Galactomannan was observed using two assays in serum and BALF samples and showed PPAs of 95.11% and 93.33%, NPAs of 89.19% and 96.30%, and TPAs of 92.47% and 94.25%, respectively. The ROC curve demonstrated that LFA had optimum diagnostic value when the index value (I value) = 0.5, the sensitivity was 84.94%, and the specificity was 90.97%. Conclusion Compared to the ELISA method, the LFA has shown excellent performance for the diagnosis of IA in serum and BALF sample and can be used as an assay for the early diagnosis of patients with IA. The dynamic change in galactomannan levels may be useful for assessing treatment response.

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Section: Resultsmentioning

confidence: 99%

Performance of the Aspergillus galactomannan lateral flow assay with a digital reader for the diagnosis of invasive aspergillosis: a multicenter study

Guo,

Xiao,

Tian

et al. 2023

Eur J Clin Microbiol Infect Dis

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Advanced Microbiological Diagnostic Techniques in Fungal Infections of the Central Nervous System

Malhotra,

Ranjan,

Suman

et al. 2023

Viral and Fungal Infections of the Central Nervous System: A Microbiological Perspective

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Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis

Yu,

Xiao,

Luo

et al. 2024

Eur J Clin Microbiol Infect Dis

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Diagnostic value of serum human Galactomannan aspergillus antigen and 1,3‐beta‐D‐glucan in immunocompromised patient suspected fungal infection

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 4 publications

References 13 publications

Performance of the Aspergillus galactomannan lateral flow assay with a digital reader for the diagnosis of invasive aspergillosis: a multicenter study

Performance of the Aspergillus galactomannan lateral flow assay with a digital reader for the diagnosis of invasive aspergillosis: a multicenter study

Advanced Microbiological Diagnostic Techniques in Fungal Infections of the Central Nervous System

Risk factors for short-term prognosis of end-stage liver disease complicated by invasive pulmonary aspergillosis

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