Diagnostic value of serum haptoglobin

Abstract

srNopsis Serum haptoglobin has been estimated quantitatively in 25 patients with haemolytic disease, and its diagnostic value assessed by comparing the levels with those obtained in 1 lOnormal subjects, in 149 patients with other forms of anaemia, and in 37 patients with non-haematological disorders. The normal range was found to be 33 to 213 mg./100 ml.; subnormal levels were found in 80% of patients with haemolytic disease or megaloblastic anaemia, patients with haemorrhage into the tissues, and occasionally in association with other diseases. When taken in conjunction with other clinical and laboratory features this simple biochemical estimation can be of diagnostic value.

Low concentration of serum haptoglobin has impact on understanding complex pathophysiology in patients with acquired bone marrow failure syndromes

“…Then, there were no significant differences in the frequencies of Hp 1-1, Hp 2-1, and Hp 2-2 haplotypes between AA or MDS patients and HV (Table 3) and no significant differences in the concentrations of serum Hp between AA patients and HV. It is well known that the decrease of serum Hp is due to mainly ineffective erythropoiesis in MDS patients [10,11]. In fact, we found the inverse correlation between concentrations of serum Hp and values of serum iron (Fig.…”

“…So far, it is known that concentration of serum Hp is influenced according to various disorders and/or pathophysiologies. Decreased concentrations of serum Hp may be observed in disorders associated with hemolytic anemia, including PNH, ineffective erythropoiesis, which is recognized in MDS, liver disease, hereditary ahaptoglobinemia, and with pregnancy and estrogen therapy, whereas increased concentrations of it may be present in any of diseases in which concentrations of acute-phase reactants are increased, such as infections and malignancies [10,11]. However, it is unclear what the frequencies of BMF syndromes patients with low concentrations of serum Hp are and over what percentages of GPI-deficient erythrocytes in patients with PNH undergo the decreased concentrations of serum Hp.…”

Polymorphism of human haptoglobin and its clinical importance

“…The serum concentration of Hp is influenced by age and is generally measurable from three months onwards, with a gradual increase until adult concentrations (30-200 mg dL -1 ) are reached at 20 years of age (Jayle and Moretti, 1962;Shinton et al, 1965). When not bound to Hb, Hp is cleared from the plasma in~3.5-5 days, but when bound to Hb, the average time for removal of the complex (mainly by hepatocytes) is~20 min (Noyes and Garby, 1967;Bissell et al, 1972;Javid, 1978).…”

‘Haptoglobin concentrations in preterm and term newborns’

“…Infants between 6-and 12-month-old have mean HPT concentrations of 115 mg dl À1 (range from 43 to 160 mg dl À1 ). 7,8 Most methods used previously have failed to consistently measure HPT in neonates, particularly at birth and in PT newborns, likely because of insufficient assay sensitivity. [9][10][11] Accurate determination of HPT in newborns is needed because of its potential utility in the clinical evaluation of hemolytic and inflammatory neonatal diseases.…”