Diagnostic value of serum angiotensin converting enzyme activity in lung diseases.

Kumar, Ashutosh; Keighley, John

doi:10.1136/thx.31.5.552

Cited by 71 publications

(19 citation statements)

References 13 publications

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“…Lieberman [4][5][6] and Lieberman et al [7] reported that serum levels of this en zyme were raised in sarcoidosis and were associated with the active disease process, serum ACE (S-ACE) appearing useful to regulate therapy and to confirm diagnosis. These findings were supported by other investigators [8][9][10][11][12]. Increased S-ACE lev els have also been observed in chronic granulomatous disorders [13][14][15][16].…”

supporting

confidence: 81%

Serum Angiotensin-I-Converting Enzyme and Lysozyme Levels in Untreated and Unsplenectomized Patients with Hodgkin’s Disease

et al. 1984

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Serum angiotensin-I-converting enzyme (S-ACE) is elevated in active sar-coidosis. In Hodgkin’s disease (HD) there are few reports with different and contrasting results. We studied S-ACE in 23 healthy controls and in 18 untreated and unsplenectomized patients with HD. In the same cases we studied also serum lysozyme. Lysozyme concentration was significantly higher in HD patients compared with normal controls (p < 0.01) and was independent of stage, systemic symptoms and presence of mediastinal involvement. S-ACE activity in HD patients was lower than in healthy controls, but not significantly. The correlation coefficient between the two enzymes showed that there was no significant correlation both in controls and in patients.

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confidence: 81%

Serum Angiotensin-I-Converting Enzyme and Lysozyme Levels in Untreated and Unsplenectomized Patients with Hodgkin’s Disease

et al. 1984

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“…Although statistical significance was not reached in an earlier series of 40 patients from our Department (R0mer, 1 980b), significantly lowered SACE in lung cancer has been reported by other investigators (Ashutosh & Keighley, 1976;Gronhagen-Riska, 1979;Lieberman et al, 1979;Silverstein et al, 1977). In only one paper a rather high SACE was noted (Turton et al, 1979).…”

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confidence: 70%

Angiotensin-converting enzyme and its association with outcome in lung cancer

Rømer¹

1981

Br J Cancer

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Summary.-Serum angiotensin-converting enzyme (SACE) in 141 patients with newly detected primary lung cancer was 22-1 + 6-1 nmol/ml/min (mean + s.d.); lower than in healthy controls (24.4 + 6-2 nmol/ml/min, P <0.02). No correlation was found between SACE and sex, age, site of cancer, histological type, or lung function.After subdivision of the patients according to increasing SACE levels: < 16.0 (mean SACE of lung cancer -s.d.), 16-0-22-0, 22-1-28-2, and >28-2 nmol/ml/min (mean SACE of lung cancer + s.d.) there was a strong association (P <0001) between SACE level and the proportion of patients who were radically operated without relapse during 8-22 months follow-up. None of 23 patients within the lowest SACE range were cured, even though 7 were referred for operation after preoperative examination. In contrast, 10/25 patients (40%O) within the highest SACE range were cured.The results suggest that low SACE is associated with poor prognosis in lung cancer, even in patients who are judged as being operable on preoperative evaluation; and measurement of preoperative SACE in lung cancer may be a useful prognostic indicator in this disorder.

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“…Hypoxic mice show high levels both in lung tissue and in serum. Elevated serum ACE levels have also been reported in adults with active sarcoidosis and infants with idiopathic respiratory distress syndrome (IRDS) (1,10,12,16). Since IRDS occurs almost exclusively in premature infants, the high levels of ACE may reflect pulmonary immaturity.…”

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confidence: 96%

Angiotensin-I-Converting Enzyme Activity in Term and Premature Infants

Bender¹,

Davitt²,

José³

1978

Neonatology

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Cord blood angiotensin-I-converting enzyme (ACE) activity was examined in 21 term and 21 premature infants Values were significantly higher in premature infants than in term infants. Cord blood ACE activity was found to have a significant negative correlation with birth weight and gestational age. ACE activity measured from peripheral blood during the first 24 h of life was higher in premature than term infants but similar to levels in maternal and adult controls. It was not possible to predict those premature infants who would develop respiratory distress syndrome on the basis of cord blood ACE activity. However, ACE may serve as a marker for maturation of the pulmonary vascular endothelial cell.

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Diagnostic value of serum angiotensin converting enzyme activity in lung diseases.

Cited by 71 publications

References 13 publications

Serum Angiotensin-I-Converting Enzyme and Lysozyme Levels in Untreated and Unsplenectomized Patients with Hodgkin’s Disease

Serum Angiotensin-I-Converting Enzyme and Lysozyme Levels in Untreated and Unsplenectomized Patients with Hodgkin’s Disease

Angiotensin-converting enzyme and its association with outcome in lung cancer

Angiotensin-I-Converting Enzyme Activity in Term and Premature Infants

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