Diagnostic Value of Segmental Longitudinal Strain by Automated Function Imaging in Coronary Artery Disease without Left Ventricular Dysfunction

Tsai, Wei Chuan; Liu, Yen Wen; Huang, Yao Yi; Lin, Chao-Cheng; Lee, Cheng‐Han; Tsai, Liang Miin

doi:10.1016/j.echo.2010.08.011

Cited by 90 publications

(85 citation statements)

References 30 publications

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“…The mechanisms of abnormal GLS in ESRD are not fully clear, but may reflect interstitial fibrosis with myocyte hypertrophy (31). Furthermore, less negative GLS may be also associated with microvascular ischemia caused by the reduction in the density of myocardial capillaries, myocardial fibrosis, or hemodialysis-related myocardial stunning (32)(33)(34)(35). Nevertheless, GLS is a reliable and early parameter to detect myocardial abnormalities such as fibrosis or ischemia, which often precede overt systolic dysfunction (9,19,20).…”

Section: Discussionmentioning

confidence: 99%

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Liu¹,

Sung

et al. 2013

Clinical Journal of the American Society of Nephrology

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101

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SummaryBackground and objectives Little is known about the optimal echocardiographic parameters for risk stratification in stable dialysis patients with preserved left ventricular ejection fraction (LVEF) (ejection fraction $50%). Left ventricular (LV) global peak systolic longitudinal strain (GLS) is the ratio of the maximal change in myocardial longitudinal length in systole to the original length and reliably and accurately assesses LV function. During systole, LV myocardium in the longitudinal direction shortens and GLS is represented by a negative value. The more negative value of GLS, the better the LV function is. This study hypothesized that subtle abnormalities of GLS are associated with an adverse prognosis.Design, setting, participants, & measurements This prospective study collected clinical and echocardiographic data (including GLS) from 88 stable hemodialysis patients (mean age 67.0611.2 years; 35% men) with preserved LVEF. These patients were enrolled from December 2008 to January 2009 and were followed-up for 25.669.9 months. The primary outcome was all-cause mortality. Multivariate Cox regression analysis was used to investigate risk factors for mortality.Results The mortality group (n=24) had lower albumin levels, less negative GLS, and higher prevalence of coronary artery disease and diabetes mellitus than the survival group. Using a GLS cutoff value of 215%, the less negative GLS group (GLS $215%) had a higher mortality rate. Cox regression analyses revealed that lower albumin level (hazard ratio, 0.16; 95% confidence interval, 0.05 to 0.53; P=0.003) and less negative GLS (hazard ratio, 3.57; 95% confidence interval, 1.41 to 9.04; P=0.01) were independent predictors of all-cause mortality. Furthermore, less negative GLS was associated with a higher cardiovascular death rate.Conclusions Less negative GLS is predictive of poor prognosis among stable hemodialysis patients with preserved LVEF.

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Section: Discussionmentioning

confidence: 99%

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Liu¹,

Sung

et al. 2013

Clinical Journal of the American Society of Nephrology

Self Cite

101

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“…The slightly lower values of strain in our study would be due to the larger proportion of patients with hypertension and diabetes mellitus in our enrolled patients; and these diseases are known to cause abnormalities in tissue velocities. Myocardial strain is relatively independent of translational motion and other through-plane motion effects, and it should be relatively homogeneous throughout the normal LV myocardium [19]. As opposed to normal hearts, the LV of the ischemic heart in our study was characterized by marked heterogeneity of myocardial systolic strain, and speckle tracking imaging demonstrated reduced shortening or stretching in the interrupted vessel territories.…”

Section: Discussionmentioning

confidence: 63%

Diagnostic Value of 2D Strain Imaging In Patients with Suspected Coronary Artery Disease

Teferici¹,

Qirko²,

Petrela³

et al. 2014

Open Access Maced J Med Sci

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“…LS and CS are considered to reflect the contraction of longitudinally arranged endocardial fibers and circumferentially arranged midlayer fibers, respectively. In general, the longitudinally arranged subendocardial fibers are more vulnerable due to their direct exposure to the intraventricular blood pressure and the anatomy of the coronary circulation (18,19). As a result, longitudinal function is impaired first in many diseases, including CAD.…”

Section: Discussionmentioning

confidence: 99%

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

Sun

Wang

Zhang

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to investigate the incremental value of resting three-dimensional speckle-tracking echocardiography (3D-STE) in the detection of early-stage left ventricular dysfunction in patients with coronary artery disease (CAD). A total of 110 patients suspected of having CAD were recruited. All patients underwent 3D-STE and coronary artery angiography (CAG). They were divided to a CAD group and a normal group according to the results of CAG. Using 3D-STE software, the peak values of longitudinal strain (LS), circumferential strain (CS), radial strain (RS) and area strain (AS) and the time to peak value of these strains (T-LS, T-CS, T-RS and T-AS) were measured. A receiver operator characteristic curve (ROC) was used to analyze the sensitivity of these strains for the diagnosis of CAD. ROC analysis indicated that T-LS and composite indices combining the peak strain value and time to peak of LS, CS and AS have diagnostic value for the early detection of CAD; the area under the curve (AUC) values were 0.667, 0.692, 0.621 and 0.672 respectively (P<0.005). The composite index of longitudinal strain demonstrated the highest diagnostic value for CAD with 62% sensitivity and 76% specificity. These results indicate that 3D-STE has incremental value for the diagnosis of CAD in patients at rest.

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Diagnostic Value of Segmental Longitudinal Strain by Automated Function Imaging in Coronary Artery Disease without Left Ventricular Dysfunction

Cited by 90 publications

References 30 publications

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Association of Left Ventricular Longitudinal Strain with Mortality among Stable Hemodialysis Patients with Preserved Left Ventricular Ejection Fraction

Diagnostic Value of 2D Strain Imaging In Patients with Suspected Coronary Artery Disease

Incremental value of resting three-dimensional speckle-tracking echocardiography in detecting coronary artery disease

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