Diagnostic value of rapid antigen detection test for streptococcal pharyngitis in a pediatric population

Çamurdan, Aysu Duyan; Çamurdan, Orhun; Ok, Ikbal; Sahın, Figen; İlhan, Mustafa; Beyazova, Ufuk

doi:10.1016/j.ijporl.2008.04.008

Cited by 23 publications

(24 citation statements)

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“…The studies were of high methodological quality, four studies met all 14 criteria [36], [48], [49], [78], nine met 13 criteria [26], [31], [34], [37], [38], [41], [43], [46], [65], three met 12 criteria [25], [32], [71], and two met 10 criteria [24], [57] (Table S3 in File S1). …”

Section: Resultsmentioning

confidence: 99%

“…Among the 28 high quality studies in the pediatrics strata and immunochromatographic methods, the sensitivity was over 90% in 14 strata (n = 3,362 patients; prevalence of GAS infection, median 32% [Q1–Q3, 28–33%]) [34], [37], [38], [43], [46], [48], [57], [65], [71], between 80–90% in eight strata (n = 4,277 patients; prevalence of GAS infection, median 25% [Q1–Q3, 24–36%]) [24], [25], [32], [34], [36], [49], and less than 80% in six strata (n = 2,685 patients; prevalence of GAS infection, median 25% [Q1–Q3, 21–29%]) [26], [31], [36], [41], [78].…”

Section: Resultsmentioning

confidence: 99%

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Rapid Antigen Group A Streptococcus Test to Diagnose Pharyngitis: A Systematic Review and Meta-Analysis

et al. 2014

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BackgroundPharyngitis management guidelines include estimates of the test characteristics of rapid antigen streptococcus tests (RAST) using a non-systematic approach.ObjectiveTo examine the sensitivity and specificity, and sources of variability, of RAST for diagnosing group A streptococcal (GAS) pharyngitis.Data SourcesMEDLINE, Cochrane Reviews, Centre for Reviews and Dissemination, Scopus, SciELO, CINAHL, guidelines, 2000–2012.Study SelectionCulture as reference standard, all languages.Data Extraction and SynthesisStudy characteristics, quality.Main Outcome(s) and Measure(s)Sensitivity, specificity.ResultsWe included 59 studies encompassing 55,766 patients. Forty three studies (18,464 patients) fulfilled the higher quality definition (at least 50 patients, prospective data collection, and no significant biases) and 16 (35,634 patients) did not. For the higher quality immunochromatographic methods in children (10,325 patients), heterogeneity was high for sensitivity (inconsistency [I2] 88%) and specificity (I2 86%). For enzyme immunoassay in children (342 patients), the pooled sensitivity was 86% (95% CI, 79–92%) and the pooled specificity was 92% (95% CI, 88–95%). For the higher quality immunochromatographic methods in the adult population (1,216 patients), the pooled sensitivity was 91% (95% CI, 87 to 94%) and the pooled specificity was 93% (95% CI, 92 to 95%); however, heterogeneity was modest for sensitivity (I2 61%) and specificity (I2 72%). For enzyme immunoassay in the adult population (333 patients), the pooled sensitivity was 86% (95% CI, 81–91%) and the pooled specificity was 97% (95% CI, 96 to 99%); however, heterogeneity was high for sensitivity and specificity (both, I2 88%).ConclusionsRAST immunochromatographic methods appear to be very sensitive and highly specific to diagnose group A streptococcal pharyngitis among adults but not in children. We could not identify sources of variability among higher quality studies. The present systematic review provides the best evidence for the wide range of sensitivity included in current guidelines.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Rapid Antigen Group A Streptococcus Test to Diagnose Pharyngitis: A Systematic Review and Meta-Analysis

et al. 2014

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“…Eyigor and Camurdan detected the sensitivity and specificity of RSAT as 94.4, 83.3% and 89.7, 97.2% respectively in their studies [20,21].…”

Section: Discussionmentioning

confidence: 99%

The sensitivity and the specifity of rapid antigen test in streptococcal upper respiratory tract infections

Gürol¹,

Akan²,

İzbırak³

et al. 2010

International Journal of Pediatric Otorhinolaryngology

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“…Apresenta especificidade em torno de 95% quando comparado à cultura de orofaringe (Santos et al, 2005;Camurdan et al, 2008;Cardoso et al, 2009;Lasseter et al, 2009;Tanz et al, 2009;Gurol et al, 2010;Rogo et al, 2010;Ruiz-Aragón et al, 2010;Cohen et al, 2012;Cardoso et al, 2013), e por essa razão, preconiza-se que nos casos em que a PRE for positiva não se realize cultura de orofaringe concomitante (Armengol et al, 2004;Edmonson;Farwell, 2005;Weber, 2014). Resultados de PRE falso positivo são raros, porém podem ocorrer quando há a presença de outros estreptocococos na orofaringe, como Streptococcus milleri, alfa-hemolíticos, que expressam em sua membrana o antígeno do carboidrato do grupo A.…”

Section: A Faringotonsiliteunclassified

“…Por outro lado, a sensibilidade é variável em função da intensidade da doença, técnica de coleta, quantidade de antígenos e tipo de kit utilizado (Armengol et al, 2004;Rimoin et al, 2005;Camurdan et al, 2008;Gerber et al, 2009;Tanz et al, 2009). Dessa forma, recomenda-se que frente a uma prova rápida negativa proceda-se a coleta de cultura de orofaringe (Webb, 1998;Woods, 1999;Linder et al, 2005;Fontes et al, 2007;Morais et al, 2009 (Santos et al, 2005;Camurdan et al, 2008;Lasseter et al, 2009;Tanz et al, 2009;Gurol et al, 2010;Rogo et al, 2010;Ruiz-Aragón et al, 2010;Cohen et al, 2012) O uso criterioso de antibiótico desempenha um papel importante na prevenção da resistência bacteriana aos antimicrobianos, na redução dos custos de cuidados na saúde, e na melhora do atendimento individual ao paciente (Deuster et al, 2010).…”

Section: A Faringotonsiliteunclassified

Impacto do uso de técnicas microbiológicas para o estreptococo beta hemolítico do grupo A no diagnóstico e tratamento das faringotonsilites

Cardoso¹

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Dedico essa obra a minha família, meu bem mais precioso Ao meu marido, Rodrigo, meu primeiro e grande amor! Meu companheiro e incentivador de todas as horas.Aos meus filhos, Beatriz e Tiago, que me tornaram uma pessoa melhor e me apresentaram ao sentimento mais pleno que existe, o AMOR incondicional.Para eles e por eles busco sempre ser melhor... Aos meus pais, Ana Maria e Flávio, sempre incentivadores do meu trabalho! Pessoas maravilhosas que investiram na formação dos meus valores morais e éticos, além de sempre terem valorizado a minha educação e terem investido na minha formação. Sempre com muito amor! Graças a esses valores concluo essa etapa tão importante de minha vida... Aos meus irmãos, Andrea e Flávio, por sua amizade e companheirismo, e por sempre me admirarem e confiarem a mim os cuidados aos seus grandes tesouros, Rafael, Isabella e Gabriella. A A G G R R A A D D E E C C I I M M E E N N T T O O S S

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Diagnostic value of rapid antigen detection test for streptococcal pharyngitis in a pediatric population

Cited by 23 publications

References 13 publications

Rapid Antigen Group A Streptococcus Test to Diagnose Pharyngitis: A Systematic Review and Meta-Analysis

Rapid Antigen Group A Streptococcus Test to Diagnose Pharyngitis: A Systematic Review and Meta-Analysis

The sensitivity and the specifity of rapid antigen test in streptococcal upper respiratory tract infections

Impacto do uso de técnicas microbiológicas para o estreptococo beta hemolítico do grupo A no diagnóstico e tratamento das faringotonsilites

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