Diagnostic Value of Presepsin in Detection of Early-Onset Neonatal Sepsis

Özdemir, Abdurrahman Avar; Elgörmüş, Yusuf

doi:10.1055/s-0036-1593851

Cited by 36 publications

(35 citation statements)

References 36 publications

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“…Presepsin has a higher sensibility and specificity in neonatal sepsis, compared to CRP and PCT. c similar to the value stated in other recent studies regarding early onset sepsis in term/ preterm newborns [25,26]. Higher PSP cutoff values, found in other studies, are in relation with the chronological age when the sample was taken.…”

Section: Resultssupporting

confidence: 87%

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

Stoicescu¹,

Mohora²,

Luminos³

et al. 2019

Rev. Chim.

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Difficulties in establishing the onset of neonatal sepsis has directed the medical research in recent years to the possibility of identifying early biological markers of diagnosis. Overdiagnosing neonatal sepsis leads to a higher rate and duration in the usage of antibiotics in the Neonatal Intensive Care Unit (NICU), which in term leads to a rise in bacterial resistance, antibiotherapy complications, duration of hospitalization and costs.Concomitant analysis of CRP (C Reactive Protein), procalcitonin, complete blood count, presepsin in newborn babies with suspicion of early or late neonatal sepsis. Presepsin sensibility and specificity in diagnosing neonatal sepsis. The study group consists of newborns admitted to Polizu Neonatology Clinic between 15th February- 15th July 2017, with suspected neonatal sepsis. We analyzed: clinical manifestations and biochemical markers values used for diagnosis of sepsis, namely the value of CRP, presepsin and procalcitonin on the onset day of the disease and later, according to evolution. CRP values may be influenced by clinical pathology. Procalcitonin values were mainly influenced by the presence of jaundice. Presepsin is the biochemical marker with the fastest predictive values of positive infection. Presepsin can be a useful tool for early diagnosis of neonatal sepsis and can guide the antibiotic treatment. Presepsin value is significantly higher in neonatal sepsis compared to healthy newborns (939 vs 368 ng/mL, p [ 0.0001); area under receiver operating curve (AUC) for presepsine was 0.931 (95% confidence interval 0.86-1.0). PSP has a greater sensibility and specificity compared to classical sepsis markers, CRP and PCT respectively (AUC 0.931 vs 0.857 vs 0.819, p [ 0.001). The cut off value for presepsin was established at 538 ng/mLwith a sensibility of 79.5% and a specificity of 87.2 %. The positive predictive value (PPV) is 83.8 % and negative predictive value (NPV) is 83.3%.

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Section: Resultssupporting

confidence: 87%

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

Stoicescu¹,

Mohora²,

Luminos³

et al. 2019

Rev. Chim.

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“…However, due to the lack of information about presepsin reference range in neonates, many studies reported different cut-off values 22,25,26. Relatively different cut-off values may be due to the use of different measurement methods.…”

Section: Discussionmentioning

confidence: 99%

<p>Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis</p>

Elmadbouly¹,

Sehemawy²,

Eldesoky³

et al. 2019

IDR

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BackgroundNeonatal sepsis (NS) is an important cause of morbidity and mortality among newborns. Its diagnosis depends mainly on blood culture that takes at least 48 hours to give results. Therefore, searching for biomarkers for early diagnosis is of value. We aimed to assess presepsin, soluble triggering receptor expressed on myeloid cells (sTREM-1), and neutrophil CD64 (nCD64) as early diagnostic biomarkers in NS, and to compare them individually and in combination.MethodsThis hospital-based case–control study has been conducted on 60 full-term neonates recruited from the neonatal intensive care unit, Al-Zahraa Hospital, Al-Azhar University, Cairo, Egypt. Thirty infants with sepsis were compared to 30 postnatal age- and sex-matched healthy controls. Studied neonates were evaluated using clinical and laboratory indicators for sepsis. nCD64 was measured by flow cytometry and, serum presepsin and sTREM-1 were measured by ELISA.ResultsPresepsin, sTREM-1, and nCD64 levels were significantly elevated in septic neonates vs control group (P<0.05). The sensitivities of presepsin, sTREM, and nCD64 were 100%, 96.7%, and 86.7%, respectively. Presepsin had the best diagnostic performance in early diagnosis of NS followed by sTREM-1 and nCD64.ConclusionPresepsin and sTREM-1 are promising biomarkers in screening for NS in comparison with nCD64. However, nCD64 is better used in combination with other biomarkers as CRP.

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“…However, its disadvantage is that it is easily affected by the subjective factors of the scorer when the neonate's score is low, often leading to inaccurate results. Besides, the Apgar score is vulnerable to other neonatal diseases, lacking specificity in the judgement (23). In this study, the changes in blood gas indexes and acid-base balance in patients with pregnancy-induced hypertension syndrome were detected, combined with the neonate's Apgar score, which could make countermeasures against neonatal asphyxia during delivery in advance.…”

Section: Discussionmentioning

confidence: 99%

Arterial blood gas and acid‑base balance in patients with pregnancy‑induced hypertension syndrome

et al. 2018

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This study aimed to investigate the expression of arterial blood gas and acid-base balance in patients with pregnancy-induced hypertension syndrome and their influence on newborns. A total of 348 patients with pregnancy-induced hypertension syndrome (research group) admitted and treated in the First People's Hospital of Jining from March 2013 to March 2016 were retrospectively analyzed, and another 156 cases of healthy pregnant women who were physically examined were selected as the control group. Blood gas analysis was performed on pregnant women, and pH value, partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2), bicarbonate radical (HCO3−) and base excess (BE) were included as test indexes. Apgar score was made for newborns for neonatal asphyxia. The evaluation was performed at 1, 5, and 10 min after birth to analyze the correlation between the maternal arterial blood pH and the neonatal Apgar score. The pH value, and PO2 and HCO3− levels in the research group were lower than those in the control group (p<0.05). PCO2 and BE levels in the research group were higher than those in the control group (p<0.05). The incidence of neonatal mild asphyxia (Apgar score, 4–6 points) and neonatal severe asphyxia (Apgar score, <4 points) in the research group were higher than that in the control group (p<0.05). The Apgar score of newborns was positively correlated with the pH value of the arterial blood of pregnant women. Blood gas analysis in patients with pregnancy-induced hypertension syndrome is useful to a certain extent to evaluate the condition of the patient. The combination of the pH value of the patient and the Apgar score of the newborns may help improve the judgement rate of neonatal asphyxia so as to improve the quality of childbirth by early monitoring and intervention of the newborns.

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Diagnostic Value of Presepsin in Detection of Early-Onset Neonatal Sepsis

Cited by 36 publications

References 36 publications

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

Presepsin - New Marker of Sepsis Romanian Neonatal Intensive Care Unit Experience

<p>Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis</p>

Arterial blood gas and acid‑base balance in patients with pregnancy‑induced hypertension syndrome

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