Diagnostic Value of Pre treatment Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio for Invasive Bladder Carcinoma

Abstract

Purpose: Oncologic outcomes in diverse malignancies are associated with inflammation-based prognostic scores including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyteto-monocyte ratio (LMR LMR (cutoff<1.8; AUC, 0.644) and PLR (cut off>218; AUC, 0.596) . Univariate analysis identified NLR, PLR, LMR, Tumour size and Tumour multiplicity as significant predictors of muscle-invasive bladder cancer (MIBC) Table: 15. The multivariate logistic regression model identified NLR (OR, 11.822; 95% CI, p=0.001) and tumour size (OR, 6.306; 95% CI, p=0.010)

Role of systemic inflammatory response markers in urological malignancy

“…The PLR, as well as the NLR, is an inexpensive and easily acquired marker that can be used after a routine preoperative blood examination. Table summarizes the results of recent reports evaluating the prognostic value of PLR . The cut‐off value for high versus low PLR varied from 117.46 to 218.…”

“…Table 13 summarizes the results of recent reports evaluating the prognostic value of PLR. 35,43,108,115,[142][143][144][145][146][147][148][149][150][151] The cutoff value for high versus low PLR varied from 117.46 to 218. Higher PLR was significantly associated with poor prognosis in five of 14 studies.…”