Diagnostic value of platelet‐lymphocyte ratio and hemoglobin‐platelet ratio in patients with rectal cancer

Mo, Cuiju; Hu, Zuojian; Qin, Simeng; Chen, Huaping; Huang, Li; Li, Shan; Cao, Zhao

doi:10.1002/jcla.23153

Cited by 20 publications

(29 citation statements)

References 31 publications

(60 reference statements)

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“…Chronic inflammation may induce changes in the tumor microenvironment and promote tumor progression. In recent years, it has been found that inflammation‐related markers such as NLR, MLR, and PLR are relevant to the early diagnosis and prognosis of tumors 12,23–27 . Among these is a new index that reflects the body's inflammatory state 28 .…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, it has been found that inflammation-related markers such as NLR, MLR, and PLR are relevant to the early diagnosis and prognosis of tumors. 12,[23][24][25][26][27] Among these is a new index that reflects the body's inflammatory state. 28 In the present study of postoperative CRC patients, we analyzed the correlation between inflammatory response LMR and DFS.…”

Section: Discussionmentioning

confidence: 99%

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Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Yao

2021

Clinical Laboratory Analysis

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Colorectal cancer (CRC) is a common malignant tumor, and its morbidity and mortality rank third among cancers worldwide. 1 In China, the incidence of CRC is gradually increasing. 2 Surgical resection is the main radical treatment for CRC, but some tumors may relapse and metastasize after surgery, shortening overall survival. 3 Diabetes is a metabolic disease characterized by high blood glucose level. There are many common inducing factors for diabetes and CRC, such as hyperlipidemia, obesity, and chronic

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Yao

2021

Clinical Laboratory Analysis

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“…An interesting, relevant finding of this study was the independent association between the HPR and long-term all-cause mortality. This parameter has been assessed in some studies, mainly concerning urological neoplasms and colon and rectal cancer [ 27 , 28 ]. In a study enrolling 6,046 patients submitted to percutaneous coronary intervention, HPR was independently associated with long-term MACE and cardiac and all-cause mortality [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Red Blood Cell Distribution Width as a 5-Year Prognostic Marker in Patients Submitted to Carotid Endarterectomy

Gamas

Jácome

Fragão-Marques

et al. 2020

Cerebrovasc Dis Extra

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Objective: Patients submitted to carotid artery endarterectomy (CEA) have a long-term risk of major adverse cardiovascular events (MACE) of 6–9% at 2 years. Hematological parameters have been shown to have a predictive function in atherosclerotic diseases, namely the red blood cell distribution width-coefficient of variation (RDW-CV). This parameter has been associated with worse outcomes such as myocardial infarction (MI), stroke, and all-cause mortality. This study aims to evaluate the potential role of preoperative hematologic parameters such as RDW-CV in predicting perioperative and long-term cardiovascular adverse events and mortality in patients submitted to CEA. Methods: From January 2012 to January 2019, 180 patients who underwent CEA with regional anesthesia in a tertiary care and referral center were selected from a prospective cohort database. Blood samples were collected preoperatively 2 weeks before admission, including a full blood count. The primary outcome included long-term MACE. Secondary outcomes included all-cause mortality, stroke, MI, acute heart failure, and major adverse limb events (MALE). Results: At baseline, 27.2% of patients had increased RDW-CV. Increased RDW-CV was independently associated with baseline hemoglobin (adjusted odds ratio [aOR] 0.715, 95% CI 0.588–0.869, p = 0.001) and atrial fibrillation (aOR 4.028, 95% CI 1.037–15.639, p = 0.001). After a median follow-up of 50 months, log-rank univariate analysis of RDW-CV demonstrated a significant association between increased RDW-CV and long-term all-cause mortality (log-rank <0.001), MACE (log-rank <0.001), and MI (log-rank = 0.017). After multivariate Cox regression analysis, increased RDW-CV was associated with increased long-term mortality (adjusted hazard ratio [aHR] 2.455, 95% CI 1.231–4.894, p = 0.011) and MACE (aHR 2.047, 95% CI 1.202–3.487, p = 0.008). A decreased hemoglobin to platelet ratio (aHR 2.650e–8, 95% CI 9.049e–15 to 0.078, p = 0.019) was also associated with all-cause mortality. Conclusion: RDW is a widely available and low-cost marker that independently predicts long-term mortality, MACE, and MI after CEA. This biomarker could prove useful in assessing which patients would likely benefit from CEA in the long term.

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“…Mekanisme yang mendasari hal ini adalah adanya kondisi anemia dan trombositosis yang didapatkan pada pasien dengan keganasan, sehingga nilai RHP yang rendah berhubungan dengan prognostik yang lebih buruk. [27][28][29] Adapun prognostik nilai RHP belum pernah diteliti apakah memiliki terhadap penyakit kardiovaskular, khususnya SKA. Pada sebagian besar pasien dengan penyakit jantung, anemia akibat penyakit kronik seringkali ditemukan.…”

Section: Diskusiunclassified

Korelasi Rasio Hemoglobin Platelet dan Rasio Leukosit Platelet terhadap Skor SYNTAX-2 pada Pasien Infark Miokard Akut dengan ST-Elevasi

Ikhsan¹,

Nasution

Rachman

et al. 2021

JPDI

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Pendahuluan. Berbagai penelitian telah melakukan analisis hubungan dan nilai prediksi antara berbagai penanda inflamasi dengan luaran klinis pasien infark miokard akut dengan ST elevasi (IMA-STE). Namun, pemeriksaan yang cukup mahal maupun ketersediaan di fasilitas kesehatan menjadi kendala untuk dilakukan pemeriksaan penanda inflamasi tersebut. Oleh karena itu, penelitian ini bertujuan melihat apakah parameter hematologi sederhana dalam hal ini rasio hemoglobin platelet (RHP) dan rasio leukosit platelet (RLP) yang juga terlibat dalam patofisiologi SKA berkorelasi dengan skor synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX-2) sebagai prediktor luaran klinis dan mortalitas pada pasien IMA-STE.Metode. Penelitian potong lintang pada pasien IMA-STE yang dirawat di ICCU RSCM kurun waktu Januari 2016 -Oktober 2020. Data dianalisis dengan uji korelasi antara RHP maupun RLP dengan skor SYNTAX-2.Hasil. Terdapat 114 subjek dalam penelitian ini, dengan rerata usia 53,87 tahun dan sebagian besar adalah pria (86,8%). Tidak didapatkan korelasi yang bermakna antara RHP maupun RLP dengan skor SYNTAX-2. Dari analisis sub-grup, didapatkan korelasi positif sedang antara RHP dengan skor SYNTAX-2 (r = 0,587; p= 0,005) dan korelasi positif kuat antara RLP dengan skor SYNTAX-2 (r = 0,606; p = 0,004) pada subjek dengan indeks massa tubuh (IMT) normal. Adapun hasil tambahan didapatkan korelasi negatif kuat antara rasio neutrofil limfosit (RNL) dengan skor SYNTAX-2 (r = -0,738; p= 0,0037) dan korelasi negatif sangat kuat antara rasio platelet limfosit (RPL) dengan skor SYNTAX-2 (r= -0,857; p= 0,007) pada IMT underweight.Simpulan. Tidak didapatkan korelasi antara RHP maupun RLP dengan skor SYNTAX-2.

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Diagnostic value of platelet‐lymphocyte ratio and hemoglobin‐platelet ratio in patients with rectal cancer

Cited by 20 publications

References 31 publications

Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Lymphocyte‐to‐monocyte ratio combined with CA19‐9 for predicting postoperative recurrence of colorectal cancer in patients with diabetes

Red Blood Cell Distribution Width as a 5-Year Prognostic Marker in Patients Submitted to Carotid Endarterectomy

Korelasi Rasio Hemoglobin Platelet dan Rasio Leukosit Platelet terhadap Skor SYNTAX-2 pada Pasien Infark Miokard Akut dengan ST-Elevasi

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