Diagnostic value of plasminogen activity level in acute mesenteric ischemia

Günerhan, Yusuf; Köksal, Neşet; Kayahan, Münire; Eryavuz, Yavuz; Sekban, Hilal

doi:10.3748/wjg.14.2540

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…Recently, several novel serum makers for AMI (eg, red cell distribution width, mean platelet volume, ischemia-modified albumin, signal peptide-CUB-EGF domain-containing protein 1) are proposed. 37 – 40 Their potential as new prognostic marker of ASMVT warrants more research.…”

Section: Discussionmentioning

confidence: 99%

D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

et al. 2014

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No early serum marker of disease severity contributes to the treatment decision-making process of acute superior mesenteric venous thrombosis (ASMVT). This study aims to assess the value of serum D-dimer level in the first 3 days after admission as a severity marker of ASMVT patients.From May 2010 to June 2014, 50 consecutive patients of ASMVT were enrolled in this observational study. The serum D-dimer level was measured on a daily basis during the first 3 days after admission as well as other laboratory-testing parameters, clinical score, and outcome variables recorded during the same period. The maximum and mean D-dimer values were analyzed and compared with other potential markers for prediction of multiple-organ dysfunction syndrome (MODS) and short-bowel syndrome (SBS). The correlation of D-dimer level with other potential severity markers and inflammation parameters were also studied.Both maximum and mean D-dimer level during the first 3 days of admission were significantly higher in patients with several clinical variables such as death within 30 days, bowel resection, sepsis, abdominal compartment syndrome, MODS, and SBS. In addition, serum D-dimer level showed precise prediction for MODS and SBS, greater than l-lactate and intestinal-type fatty acid-binding protein (I-FABP). The D-dimer level was correlated well with l-lactate, I-FABP, and APACHE II score on the first 3 days of admission. Poor correlation of D-dimer level and inflammation parameters, white blood cell count, and C-reactive protein level, was detected.D-dimer level could be an effective, early, and specific serum marker indicating the clinical evolution and outcome of ASMVT.

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Section: Discussionmentioning

confidence: 99%

D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

et al. 2014

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“…There are no established serum parameters with appropriate sensitivity or specificity for diagnosis of mesenteric ischemia [4, 13, 18]. Although up to 90% of patients with mesenteric ischemia have elevated serum lactate, conversely, patients with acute abdominal pain without mesenteric ischemia often reveal elevated lactate levels too.…”

Section: Introductionmentioning

confidence: 99%

Acute Mesenteric Infarction: The Chameleon of Acute Abdomen Evaluating the Quality of the Diagnostic Parameters in Acute Mesenteric Ischemia

et al. 2021

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Introduction/Objective: Acute mesenteric ischemia (AMI) is difficult to diagnose. Since the established parameters have low sensitivity and specificity, the aim of this study is to analyze the diagnostic quality of the established parameters of AMI. Methods: All patients that underwent emergency surgery due to suspected diagnosis of mesenteric ischemia at the University Medical Center Hamburg-Eppendorf between 2008 and 2014 were evaluated. Overall, 275 patients were enrolled and pre-, intra- and postoperative data were evaluated. Results: In 200 patients, a mesenteric ischemia was confirmed intraoperatively, and 75 patients had no ischemia. Comparing these groups, the rate of patients with pH < 7.2 (25 vs. 12%; p = 0.021) and elevated mean CRP level (175 ± 117 mg/L vs. 139 ± 104 mg/L; p = 0.019) was significantly higher in ischemic patients. There was no significant difference in the level of preoperative lactate. Concerning abdominal CT scan, a sensitivity and specificity of 61 and 68%, respectively, was found. Conclusion: New diagnostic parameters are needed. So far, explorative laparotomy is the only reliable diagnostic method to detect mesenteric infarction.

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Akuter Intestinalarterienverschluss (S2)

Gefäßchirurgie¹

2010

Leitlinien Zu Diagnostik Und Therapie in Der Gefäßchirurgie

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Diagnostic value of plasminogen activity level in acute mesenteric ischemia

Cited by 5 publications

References 15 publications

D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

D-Dimer as an Early Marker of Severity in Patients With Acute Superior Mesenteric Venous Thrombosis

Acute Mesenteric Infarction: The Chameleon of Acute Abdomen Evaluating the Quality of the Diagnostic Parameters in Acute Mesenteric Ischemia

Akuter Intestinalarterienverschluss (S2)

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