Diagnostic value of PET-measured heterogeneity in myocardial blood flows during cold pressor testing for the identification of coronary vasomotor dysfunction

Schindler, Thomas H.; Zhang, Xiao Li; Vincenti, Gabriella; Mhiri, Leila; Nkoulou, René; Just, H; Ratib, Osman; Mach, François; Dahlbom, Magnus; Schelbert, Heinrich R.

doi:10.1016/j.nuclcard.2007.06.120

Cited by 25 publications

(14 citation statements)

References 46 publications

(86 reference statements)

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“…[76][77][78] Consequently, resting MBF is commonly higher in patients with higher arterial blood pressure or heart rate. 67,70,79,80 Age-related increases in resting MBF can be explained by rate-pressure product correction of increased systolic blood pressures. 67,81 Most of the reported PET-determined resting MBF values have been higher in women than in men.…”

Section: Resting Mbfmentioning

confidence: 99%

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Murthy

Bateman²,

Beanlands

et al. 2018

Journal of Nuclear Cardiology

169

111

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Section: Resting Mbfmentioning

confidence: 99%

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Murthy

Bateman²,

Beanlands

et al. 2018

Journal of Nuclear Cardiology

169

111

View full text Add to dashboard Cite

“…A blood pool TAC was generated by placing a small ROI in the center of the left ventricle of the last frame of the dynamic short axis images. This procedure was applied to both the rest and stress data (11). …”

Section: Methodsmentioning

confidence: 99%

Absolute Quantitation of Myocardial Blood Flow in Human Subjects With or Without Myocardial Ischemia Using Dynamic Flurpiridaz F 18 PET

et al. 2014

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Absolute quantitation of myocardial blood flow (MBF) by positron emission tomography (PET) is an established method of analyzing coronary artery disease (CAD) but subject to the various shortcomings of available radiotracers. Flurpiridaz F 18 is a novel PET radiotracer which exhibits properties of an ideal tracer. Methods A new absolute perfusion quantitation method with Flurpiridaz was developed, taking advantage of the early kinetics and high first-pass extraction by the myocardium of this radiotracer, and the first in human measurements of MBF performed in 7 normal subjects and 8 patients with documented CAD. PET images with time-activity curves were acquired at rest and during adenosine stress. Results In normal subjects, regional MBF between coronary artery territories did not differ significantly, leading to a mean global MBF of 0.73 mL/min/g at rest and 2.53 mL/min/g during stress, with a mean global myocardial flow reserve (MFR) of 3.70. CAD vascular territories with <50% stenosis demonstrated a mean MBF of 0.73 at rest and 2.02 during stress, leading to a mean MFR of 2.97. CAD vascular territories with ≥50% stenosis exhibited a mean MBF of 0.86 at rest and 1.43 during stress, leading to a mean MFR of 1.86. Differences in stress MBF and MFR between normal and CAD territories, as well as between <50% and ≥50% stenosis vascular territories, were significant (P<0.01). Conclusion Absolute quantitation of MBF in humans with the novel PET radiotracer Flurpiridaz is feasible over a wide range of cardiac flow in the presence or absence of stress-inducible myocardial ischemia. The significant decrease in stress MBF and ensuing MFR in CAD territories allows a clear distinction between vascular territories exhibiting stress-inducible myocardial ischemia and those with normal perfusion.

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“…More recently, measurement of MBF with PET in response to a cold pressure test (CPT) has been used as a noninvasive tool for the assessment of endothelial function (55). The accuracy, reproducibility, and clinical value of this approach have been validated in several studies by different groups (56)(57)(58)(59).…”

Section: Mbf and Overt Cadmentioning

confidence: 99%

The Clinical Value of Myocardial Blood Flow Measurement

2009

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PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro-and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angiographically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.

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Diagnostic value of PET-measured heterogeneity in myocardial blood flows during cold pressor testing for the identification of coronary vasomotor dysfunction

Abstract: The combined evaluation of a CPT-induced heterogeneity in longitudinal MBF and the change in global MBF from rest may emerge as a new promising analytic approach to further optimize the identification and characterization of coronary vasomotor dysfunction.

Cited by 25 publications

References 46 publications

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Clinical Quantification of Myocardial Blood Flow Using PET: Joint Position Paper of the SNMMI Cardiovascular Council and the ASNC

Absolute Quantitation of Myocardial Blood Flow in Human Subjects With or Without Myocardial Ischemia Using Dynamic Flurpiridaz F 18 PET

The Clinical Value of Myocardial Blood Flow Measurement

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