Diagnostic value of neurofilaments in differentiating motor neuron disease from multifocal motor neuropathy
Camilla Wohnrade,
Tabea Seeliger,
Stefan Gingele
et al.
Abstract:Objective
To evaluate the performance of serum neurofilament light chain (NfL) and cerebrospinal fluid (CSF) phosphorylated neurofilament heavy chain (pNfH) as diagnostic biomarkers for the differentiation between motor neuron disease (MND) and multifocal motor neuropathy (MMN).
Methods
This retrospective, monocentric study included 16 patients with MMN and 34 incident patients with MND. A subgroup of lower motor neuron (MN) dominant MND patients (n = 24) … Show more
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