Diagnostic Value of Natural Fill
Cystometry in Neurogenic Bladder
in Children

Zermann, Dirk‐Henrik; Lindner, Holger A.; Huschke, T; Schubert, Jörg

doi:10.1159/000480863

Cited by 21 publications

(4 citation statements)

References 9 publications

(10 reference statements)

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“…The standards of the International Children's Continence Society should be applied and accordingly reported . Natural filling UDS in children with a neurogenic bladder can detect more overactivity compared with conventional UDS . It may be an option in cases, where the findings in conventional UDS are inconsistent with symptoms and other clinical findings …”

Section: Methodsmentioning

confidence: 99%

“…14,23 Natural filling UDS in children with a neurogenic bladder can detect more overactivity compared with conventional UDS. 24,25 It may be an option in cases, where the findings in conventional UDS are inconsistent with symptoms and other clinical findings. 25 DMSA ( 99 technetium dimercaptosuccinic acid renal) scan is still the gold standard to detect renal scars, which can be seen in up to 46% of older patients with neurogenic bladders.…”

Section: Urodynamic Studiesmentioning

confidence: 99%

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EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

Stein

Bogaert

Doğan

et al. 2019

Neurourology and Urodynamics

108

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Background: In childhood, the most common reason for a neurogenic bladder is related to spinal dysraphism, mostly myelodysplasia.Aims: Herein, we present the EAU/ESPU guidelines in respect to the diagnostics, timetable for investigations and conservative management including clean intermittent catheterization (CIC). Material and Methods: After a systematic literature review covering the period 2000 to 2017, the ESPU/EUAU guideline for neurogenic bladder underwent an update. Results: The EAU/ESPU guideline panel advocates a proactive approach. In newborns with spina bifida, CIC should be started as soon as possible after birth. In those with intrauterine closure of the defect, urodynamic studies are recommended be performed before the patient leaves the hospital. In those with closure after birth urodynamics should be done within the next 3 months. Anticholinergic medication (oxybutynin is the only well-investigated drug in this age group-dosage 0.2-0.4 mg/kg weight per day) should be applied, if the urodynamic study confirmed detrusor overactivity. Close follow-up including ultrasound, bladder diary, urinalysis, and urodynamics are necessary within the first 6 years and after that the time intervals can be prolonged, depending on the individual risk and clinical course. In all other children with the suspicion of a neurogenic bladder due to various reasons as tethered cord, inflammation, tumors, trauma, or other reasons as well as those with anorectal malformations, urodynamics-preferable video-urodynamics, should be carried out as soon as there is a suspicion of a neurogenic bladder and conservative treatment should be started soon after confirmation of the diagnosis of neurogenic bladder. With conservative treatment the upper urinary tract is preserved in up to 90%, urinary tract infections are common, but not severe, complications of CIC are quite rare and continence can be achieved at adolescence in up to 80% without further treatment. ORCID Raimund Stein

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Section: Methodsmentioning

confidence: 99%

Section: Urodynamic Studiesmentioning

confidence: 99%

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

Stein

Bogaert

Doğan

et al. 2019

Neurourology and Urodynamics

108

View full text Add to dashboard Cite

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“…AUM has previously been compared to conventional UDS identifying neurogenic bladder dysfunction which could be hazardous to kidney function. They all show that AUM tracings reveal significantly more bladder contractions, lower bladder capacities, lower pressure rises during filling and lower end filling pressures, and a higher voiding detrusor pressure . The overall consensus so far has been, that AUM albeit more representative of the patient́s real lower urinary function does not surpass conventional UDS when it comes to clinical use.…”

Section: What Is the Clinical Utility Of Aum?mentioning

confidence: 96%

What is the utility of urodynamics, including ambulatory, and 24 h monitoring, in predicting upper urinary tract damage in neuro‐urological patients and other lower urinary tract dysfunction? ICI‐RS 2017

Rantell

Averbeck

et al. 2018

Neurourology and Urodynamics

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“…Because of increased stiffness and cell adherence to the endothelium, the circulation of sickle cells through the body's narrow blood vessels, such as arterioles, venules, and capillaries, is often obstructed resulting in infarctions and organ damage (23,50,279). In addition, overt stroke caused by occlusion of large cerebral arteries is one of the main complications of sickle-cell disease (62,(280)(281)(282). Since polymerized HbS fibers are stiff, they create protrusions and cause vesiculation of the RBC membrane (35).…”

Section: Introductionmentioning

confidence: 99%

A Coarse-Grained Molecular Dynamics Model for Sickle Hemoglobin Fibers

Lykotrafitis

2010

Volume 9: Mechanics of Solids, Structures and Fluids

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The intracellular polymerization of deoxy sickle cell hemoglobin (HbS) has been identified as the main cause of sickle cell disease. Therefore, the material properties and biomechanical behavior of polymerized HbS fibers have been a topic of intense research interest. A solvent-free coarse-grained molecular dynamics (CGMD) model has been developed and it represents a single hemoglobin fiber with four tightly bonded chains, each of which comprises soft particles. A harmonic spring potential, a bending potential, a torsional potential, and a Lennard-Jones potential are introduced along with a Langevin thermostat to simulate the behavior of a polymerized HbS fiber in the cytoplasm. The parameters of the potentials are identified via comparison of the simulation results with the experimentally measured values of bending and torsional rigidity of single HbS fibers. The proposed model is able to very efficiently simulate HbS fibers of 20 nm diameter and on the order of μm length-scale and μs time-scale. The model is validated by comparison with published experimental results and then it is used to investigate the interaction between two HbS fibers, and to study the fiber zippering process during heterogeneous fiber growth.

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Diagnostic Value of Natural Fill Cystometry in Neurogenic Bladder in Children

Cited by 21 publications

References 9 publications

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

EAU/ESPU guidelines on the management of neurogenic bladder in children and adolescent part I diagnostics and conservative treatment

What is the utility of urodynamics, including ambulatory, and 24 h monitoring, in predicting upper urinary tract damage in neuro‐urological patients and other lower urinary tract dysfunction? ICI‐RS 2017

A Coarse-Grained Molecular Dynamics Model for Sickle Hemoglobin Fibers

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