Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury

Kim, Sangmi; Lee, Hyunseung; Kim, Minji; Park, Hyung-Doo; Lee, Soo-Youn

doi:10.3390/jcm10215005

Cited by 7 publications

(8 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found that cystatin C was significantly elevated patients with vancomycin induced kidney injury compared to the two control groups (with and without vancomycin therapy). Cystatin C showed strong negative correlation with eGFR and remained a significant factor associated with the development for kidney injury in the multivariable logistic regression model [62].…”

Section: The Use Of Cystatin C Estimated Glomerular Filtration Rate I...mentioning

confidence: 89%

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C

Tio

Shafi

Zhu

et al. 2022

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

Purpose of review Glomerular filtration rate (GFR) is the best index for kidney function and estimated GFR (eGFR) calculated from endogenous filtration markers like serum creatinine and cystatin C is widely used in clinical practice for chronic kidney disease diagnosis and prognostication. We sought to review the evolution of GFR estimating equations, nuances of eGFR interpretation, and utility of eGFR in drug dosing. Recent findings The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) serum creatinine eGFR equation was recently updated to exclude the race variable and the CKD-EPI creatinine–cystatin C equation demonstrated the highest reliability. Although calculated creatinine clearance by Cockcroft Gault has been traditionally used for drug dosing, the use of eGFR is slowly being adapted by the Food and Drug Administration for pharmacokinetic studies. However, the individual-level accuracy of eGFR using the CKD-EPI 2021 equations remained low, with the distribution of measured GFR at a given eGFR value spanning several CKD stages. Summary Although current methods of estimating GFR have improved in population measures of reliability, all have significant individual-level inaccuracies that can be an issue when clinical decision-making is contingent on the actual level of GFR. Modern methods of GFR measurements should be made widely available to enhance individualized patient decision-making.

show abstract

Section: The Use Of Cystatin C Estimated Glomerular Filtration Rate I...mentioning

confidence: 89%

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C

Tio

Shafi

Zhu

et al. 2022

Current Opinion in Nephrology &Amp; Hypertension

View full text Add to dashboard Cite

show abstract

“…Furthermore, Kim et al retrospectively compared serum biomarkers among patients with and without VA-AKI. They found that serum cystatin C (AUC 0.92), trefoil factor-3 (AUC 0.93), tumor necrosis factor receptor 1 TNF-R1 (AUC 0.87), and osteopontin (AUC 0.79) exhibited excellent to outstanding diagnostic abilities for VA-AKI [66].…”

Section: Biomarkers For Detecting Va-akimentioning

confidence: 99%

Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application

Chen

Shiao

2022

IJMS

View full text Add to dashboard Cite

Vancomycin is the most frequently used antibiotic, accounting for up to 35% of hospitalized patients with infection, because of its optimal bactericidal effectiveness and relatively low price. Vancomycin-associated AKI (VA-AKI) is a clinically relevant but not yet clearly understood entity in critically ill patients. The current review comprehensively summarizes the pathophysiological mechanisms of, biomarkers for, preventive strategies for, and some crucial issues with VA-AKI. The pathological manifestations of VA-AKI include acute tubular necrosis, acute tubulointerstitial nephritis (ATIN), and intratubular crystal obstruction. The proposed pathological mechanisms of VA-AKI include oxidative stress and allergic reactions induced by vancomycin and vancomycin-associated tubular casts. Concomitant administration with other nephrotoxic antibiotics, such as piperacillin–tazobactam, high vancomycin doses, and intermittent infusion strategies compared to the continuous infusion are associated with a higher risk of VA-AKI. Several biomarkers could be applied to predict and diagnose VA-AKI. To date, no promising therapy is available. Oral steroids could be considered for patients with ATIN, whereas hemodialysis might be applied to remove vancomycin from the patient. In the future, disclosing more promising biomarkers that could precisely identify populations susceptible to VA-AKI and detect VA-AKI occurrence early on, and developing pharmacological agents that could prevent or treat VA-AKI, are the keys to improve the prognoses of patients with severe infection who probably need vancomycin therapy.

show abstract

“…It is filtered from the blood by the glomerulus and then metabolized in the proximal tubules [9]. It is considered an early marker of AKI related to glomerular filtration rate (GFR) [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive Silicon Nanowire Biosensor with Modulated Threshold Voltages and Ultra-Small Diameter for Early Kidney Failure Biomarker Cystatin C

Zhang

et al. 2023

Biosensors

View full text Add to dashboard Cite

Acute kidney injury (AKI) is a frequently occurring severe disease with high mortality. Cystatin C (Cys-C), as a biomarker of early kidney failure, can be used to detect and prevent acute renal injury. In this paper, a biosensor based on a silicon nanowire field-effect transistor (SiNW FET) was studied for the quantitative detection of Cys-C. Based on the spacer image transfer (SIT) processes and channel doping optimization for higher sensitivity, a wafer-scale, highly controllable SiNW FET was designed and fabricated with a 13.5 nm SiNW. In order to improve the specificity, Cys-C antibodies were modified on the oxide layer of the SiNW surface by oxygen plasma treatment and silanization. Furthermore, a polydimethylsiloxane (PDMS) microchannel was involved in improving the effectiveness and stability of detection. The experimental results show that the SiNW FET sensors realize the lower limit of detection (LOD) of 0.25 ag/mL and have a good linear correlation in the range of Cys-C concentration from 1 ag/mL to 10 pg/mL, exhibiting its great potential in the future real-time application.

show abstract

Diagnostic Value of Multiple Serum Biomarkers for Vancomycin-Induced Kidney Injury

Cited by 7 publications

References 63 publications

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C

Traditions and innovations in assessment of glomerular filtration rate using creatinine to cystatin C

Vancomycin-Associated Acute Kidney Injury: A Narrative Review from Pathophysiology to Clinical Application

Ultrasensitive Silicon Nanowire Biosensor with Modulated Threshold Voltages and Ultra-Small Diameter for Early Kidney Failure Biomarker Cystatin C

Contact Info

Product

Resources

About