Diagnostic value of medical thoracoscopy in malignant pleural effusion induced by non‑Hodgkin's lymphoma

Wang, Zhen; Wu, Youlong; Xu, Lili; Jin, Mulan; Diao, Xiaoli; Wang, Xiaojuan; Tong, Zhaohui; Shi, Huan‐Zhong

doi:10.3892/ol.2017.7226

Cited by 6 publications

(6 citation statements)

References 47 publications

(40 reference statements)

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“…Medical thoracoscopy is considered to be a gold-standard method in diagnosing MPE. However, as an invasive technique, it may cause complications and increase morbidity (13)(14)(15). Therefore, novel tests and markers are called for discriminating between MPE and benign pleural effusion.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of CD206+CD14+ macrophages in diagnosis of lung cancer originated malignant pleural effusion

Pei¹,

Wu²,

Yi³

et al. 2019

J. Thorac. Dis

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Background: Pleural effusions are common complications of various diseases. Patients with malignant pleural effusion (MPE) usually face poor prognosis and short life expectancy. Discriminating between MPE and benign pleural effusion remains to be difficult. The aim of our current study was to evaluate whether CD206 + CD14 + macrophages could be a diagnostic biomarker for MPE. Methods: The percentages of CD14 + , CD86 + CD14 + and CD206 + CD14 + macrophages in pleural effusions were determined by flow cytometry in 34 patients with MPE and 26 with benign pleural effusion, and their diagnostic performances were evaluated by receiver operating characteristic (ROC) curves. Results: The percentages of CD14 + , CD86 + CD14 + and CD206 + CD14 + macrophages were remarkably higher in MPE than in benign pleural effusion (all P<0.05). With a cutoff value of 39.8%, a high sensitivity of 88.2% and high specificity of 100.0% were found in CD206 + CD14 + macrophages to diagnose MPE. The area under the curve, positive predictive value and negative predictive value of CD206 + CD14 + macrophages were 0.980 (95% CI, 0.905 to 0.999), 100.0 (88.4 to 100.0) and 86.7 (69.3 to 96.2), respectively. The diagnostic performance of CD206 + CD14 + macrophages was more accurate than those of CD14 + and CD86 + CD14 + macrophages. Conclusions: CD206 + CD14 + macrophages could be used to discriminate MPE from benign pleural effusion.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of CD206+CD14+ macrophages in diagnosis of lung cancer originated malignant pleural effusion

Pei¹,

Wu²,

Yi³

et al. 2019

J. Thorac. Dis

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“…The proposed pathophysiological mechanisms of action are: (a) Direct infiltration of the pleural space; (b) lymphatic obstruction with infiltration of pulmonal and mediastinal lymph nodes and; (c) obstruction of the ductus thoracicus , which leads to the formation of a chylothorax. New studies show that the main mechanisms are infiltration of the pleural space and tumor-host cell interactions [51,52,53].…”

Section: Cancer and Malignant Pleural Effusionmentioning

confidence: 99%

“…HL has a bimodal peak in incidence for 15–34 years and after 50 years [36,50]. MPE presents in patients with HL in 10–30% at the time of initial diagnosis, in 60% of patients it develops during disease progression [51]. Lymphomas are the most common reason for MPE formation in children and can also occur in cases of primary lymphoma of the pleura [36].…”

Section: Cancer and Malignant Pleural Effusionmentioning

confidence: 99%

Malignant Pleural Effusion and Its Current Management: A Review

et al. 2019

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Malignant pleural effusion (MPE) is an exudative effusion with malignant cells. MPE is a common symptom and accompanying manifestation of metastatic disease. It affects up to 15% of all patients with cancer and is the most common in lung, breast cancer, lymphoma, gynecological malignancies and malignant mesothelioma. In the last year, many studies were performed focusing on the pathophysiological mechanisms of MPE. With the advancement in molecular techniques, the importance of tumor-host cell interactions is becoming more apparent. Additionally, the process of pathogenesis is greatly affected by activating mutations of EGFR, KRAS, PIK3CA, BRAF, MET, EML4/ALK and RET, which correlate with an increased incidence of MPE. Considering all these changes, the authors aim to present a literature review of the newest findings, review of the guidelines and pathophysiological novelties in this field. Review of the just recently, after seven years published, practice guidelines, as well as analysis of more than 70 articles from the Pubmed, Medline databases that were almost exclusively published in indexed journals in the last few years, have relevance and contribute to the better understanding of the presented topic. MPE still presents a severe medical condition in patients with advanced malignancy. Recent findings in the field of pathophysiological mechanisms of MPE emphasize the role of molecular factors and mutations in the dynamics of the disease and its prognosis. Treatment guidelines offer a patient-centric approach with the use of new scoring systems, an out of hospital approach and ultrasound. The current guidelines address multiple areas of interest bring novelties in the form of validated prediction tools and can, based on evidence, improve patient outcomes. However, the role of biomarkers in a clinical setting, possible new treatment modalities and certain specific situations still present a challenge for new research.

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“…In lymphomatous effusion, positive cytology is reported in 14% to 88% of cases (14). In cases of negative cytology and negative cultures, a thoracoscopic pleural biopsy may be needed to make a definite diagnosis (15).…”

Section: Discussionmentioning

confidence: 99%

<i>Salmonella enterica</i> Subspecies <i>arizonae</i> Detected from Bilateral Pleural Fluid in a Patient with Systemic Lupus Erythematosus and Malignant Lymphoma

et al. 2020

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A 72-year-old woman was admitted to our hospital with bilateral pleural effusions. She had a 31-year history of systemic lupus erythematosus and had been treated with prednisolone and azathioprine. Pleural fluid culture revealed Salmonella enterica subsp. arizonae infection. This pathogen rarely infects humans but is commonly found in the gut flora of reptiles, especially snakes. Our patient had not come in contact with reptiles. Despite antibiotic therapies and negative pleural cultures, the pleural effusion persisted. Colon cancer was detected concomitantly, and she finally died. The autopsy revealed that the pleuritis was due to underlying diffuse large B cell lymphoma.

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Diagnostic value of medical thoracoscopy in malignant pleural effusion induced by non‑Hodgkin's lymphoma

Cited by 6 publications

References 47 publications

Diagnostic value of CD206+CD14+ macrophages in diagnosis of lung cancer originated malignant pleural effusion

Diagnostic value of CD206+CD14+ macrophages in diagnosis of lung cancer originated malignant pleural effusion

Malignant Pleural Effusion and Its Current Management: A Review

<i>Salmonella enterica</i> Subspecies <i>arizonae</i> Detected from Bilateral Pleural Fluid in a Patient with Systemic Lupus Erythematosus and Malignant Lymphoma

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