Diagnostic value of matrix metalloproteinases-1, −3 and −13 in patients with primary knee osteoarthritis: Relation to radiological severity

Elamir, Azza; Zahra, Amr; Senara, Soha; Ezzat, Eman; Sayed, Hassan Salem El

doi:10.1016/j.ejr.2022.09.002

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…MMPs take part in degrading aggrecan, which is a typical hallmark of OA [116]. The family comprises 23 enzymes in humans [117] and their increased levels were identified in both the blood and SF of OA patients [118][119][120][121]. Based on their structure and substrate specificity, the family is divided into several subgroups, including typical proteinases (e.g., MMP-1,-9,-13), gelatinases (MMP-2, MMP-9), matrilysins (MMP-7, -16) and those that are membrane bound (e.g., MMP-14, -15, -17), among others [122].…”

Section: Matrix Metalloproteinasesmentioning

confidence: 99%

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Kiełbowski

Herian

Bakinowska

et al. 2023

IJMS

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Osteoarthritis (OA) is progressive disease characterised by cartilage degradation, subchondral bone remodelling and inflammation of the synovium. The disease is associated with obesity, mechanical load and age. However, multiple pro-inflammatory immune mediators regulate the expression of metalloproteinases, which take part in cartilage degradation. Furthermore, genetic factors also contribute to OA susceptibility. Recent studies have highlighted that epigenetic mechanisms may regulate the expression of OA-associated genes. This review aims to present the mechanisms of OA pathogenesis and summarise current evidence regarding the role of genetics and epigenetics in this process.

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Section: Matrix Metalloproteinasesmentioning

confidence: 99%

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Kiełbowski

Herian

Bakinowska

et al. 2023

IJMS

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Live and Dead Clostridium butyricumGKB7 Diminish Osteoarthritis Pain and Progression in Preclinical Animal Model

Chen,

Lin,

Tsai

et al. 2024

Environmental Toxicology

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Osteoarthritis (OA) is a degenerative joint disease primarily affecting the elderly. It is characterized by the progressive decline of joint cartilage and alterations in the underlying bone. Several probiotic strains have exhibited immunomodulatory and anti‐inflammatory properties. Here, we examined the functions of live and dead Clostridium butyricum GKB7 (GKB7‐L and GKB7‐D) in a preclinical anterior cruciate ligament transection (ACLT)‐enhanced OA procedure. Oral administration of GKB7‐L and GKB7‐D ameliorated ACLT‐induced bone pain as assessed by weight‐bearing behavioral testing but did not affect body weight. Micro‐computed tomography (CT) results showed that GKB7‐L and GKB7‐D diminished ACLT‐induced bone destruction and loss. GKB7‐L and GKB7‐D‐enriched therapies also reduced ACLT‐induced production of the pro‐inflammatory cytokines interleukin (IL)‐1β and tumor necrosis factor (TNF)‐α, as well as the chondrolytic factor matrix metalloproteinase (MMP)‐3, leading to inhibition of aggrecan and collagen type II degradation and thereby blocking cartilage breakdown. We therefore suggest that oral supplementation with GKB7‐L or GKB7‐D can be beneficial in the prevention and treatment of OA.

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Osteoarthritis year in review 2023: metabolite and protein biomarkers

Liu,

Haque,

Huang

et al. 2023

Osteoarthritis and Cartilage

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Diagnostic value of matrix metalloproteinases-1, −3 and −13 in patients with primary knee osteoarthritis: Relation to radiological severity

Cited by 3 publications

References 32 publications

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Live and Dead Clostridium butyricumGKB7 Diminish Osteoarthritis Pain and Progression in Preclinical Animal Model

Osteoarthritis year in review 2023: metabolite and protein biomarkers

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