Diagnostic value of indocyanine green fluorescence guided sentinel lymph node biopsy in vulvar cancer: A systematic review

Koual, Meriem; Benoit, Louise; Nguyen-Xuan, Huyên-Thu; Bentivegna, Enrica; Azaïs, Henri; Bats, Anne‐Sophie

doi:10.1016/j.ygyno.2021.01.031

Cited by 23 publications

(15 citation statements)

References 36 publications

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“…Recent systematic reviews and meta-analyses ( 35 , 37 – 41 ) on SLN mapping technology concerning gynecological malignant tumors are concluded in Supplementary Table 1 .…”

Section: Introduction To Sentinel Lymph Node Techniquesmentioning

confidence: 99%

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Wang

Shao

et al. 2022

Front. Med.

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The sentinel lymph nodes (SLNs) is a group of lymph nodes initially involved in the metastatic spread of cancer cells. SLN mapping refers to intraoperative localization and biopsy of SLNs with specific tracers to assess lymph node metastases. It is widely used in a variety of tumor surgeries for its high sensitivity and high negative predictive value. In the evaluation of the status of lymph node metastases in gynecological malignancies, it has received increasingly more attention due to its minor invasiveness, few complications, and high diagnosis rate. The National Comprehensive Cancer Network (NCCN) guidelines provide an excellent introduction to the indications and methods of SLN techniques in vulvar, cervical, and endometrial cancers, but they provide little explanation about some specific issues. In this review, we summarize different dyes and injection methods and discuss the indications of application and the clinical trials of SLN mapping in gynecological malignant tumors, aiming to provide a reference for the rational application of sentinel techniques in gynecology malignant tumors before relevant guidelines are updated.

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“…Recent systematic reviews and meta-analyses ( 35 , 37 – 41 ) on SLN mapping technology concerning gynecological malignant tumors are concluded in Supplementary Table 1 .…”

Section: Introduction To Sentinel Lymph Node Techniquesmentioning

confidence: 99%

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Wang

Shao

et al. 2022

Front. Med.

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“…In brief, a bolus of ICG is injected into the patient intravenously, NIR light is then absorbed by ICG in the tissue, and the resulting fluorescence is a reflection of perfusion. After the introduction of ICG angiography in clinical practice in 1989 to evaluate choroidal circulation[ 14 ], fluorescence imaging technology has been used in hepatobiliary[ 15 , 16 ], gastric cancer[ 17 ], gynecologic cancer[ 18 ], breast cancer[ 19 ] and transplantation surgery[ 20 ]. Furthermore, many colorectal surgeons routinely use ICG imaging to assess bowel viability during colorectal anastomosis.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art

Peltrini¹,

Podda²,

Castiglioni³

et al. 2021

WJG

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Indocyanine green (ICG) fluorescence imaging is widely used in abdominal surgery. The implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical systems. In that setting, ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic flow. The purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer surgery. Each type of use has been separately addressed and the evidence was investigated. During rectal resection, ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic leaks. In addition, ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from injury. This intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is performed. This is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the literature. Although further studies are need to investigate the real clinical benefits, these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications.

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“…Based on this evidence, this technique has been extended to vulvar cancers. Recently, several studies have shown the feasibility, accuracy, and safety of SLN mapping using ICG with near-infrared fluorescence imaging in vulvar cancer [ 7 , 8 ].…”

mentioning

confidence: 99%

Indocyanine green fluorescent image-guided inguinal sentinel lymph node biopsy in vulvar cancer

Kwak¹,

Lee²,

Lee³

et al. 2022

Obstet Gynecol Sci

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ObjectiveTo demonstrate near-infrared fluorescence image-guided inguinal sentinel lymph node (SLN) biopsy in patients with vulvar cancer.MethodsA 40-year-old woman with a 3-cm-sized palpable left vulvar mass was diagnosed with vulvar cancer on biopsy with protrusion into the vaginal cavity. Pelvic contrast-enhanced magnetic resonance imaging and F-18 fluorodeoxyglucose positron-emission tomography-computed tomography showed a small ulcerative enhancing lesion confined to the left vulva without distant metastasis. The patient was scheduled for radical vulvectomy with a left inguinal SLN biopsy. Indocyanine green was injected directly into the vulvar mass to map lymphatic drainage. A 4-cm-sized linear incision was made on the left inguinal crease, and the lymphatic channels of the left inguinal area were dissected under fluorescent image guidance using a 1588 Advanced Imaging Modalities Platform laparoscopic camera (Stryker, Kalamazoo, MI, USA).ResultsFluorescence image-guided left inguinal SLN biopsy and radical vulvectomy were performed. The pathologic diagnosis confirmed vulvar adenoid cystic carcinoma with metastasis to the left inguinal lymph node (International Federation of Gynecology and Obstetrics stage IIIA). The patient was discharged without complications and received adjuvant radiotherapy.ConclusionThis video demonstrates a successful ICG fluorescence image-guided left inguinal SLN biopsy in a vulvar cancer patient using a laparoscopic camera. Mapping of inguinal SLNs in patients with vulvar cancer may help in retaining surgical radicality while minimizing operative complications.

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Diagnostic value of indocyanine green fluorescence guided sentinel lymph node biopsy in vulvar cancer: A systematic review

Cited by 23 publications

References 36 publications

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art

Indocyanine green fluorescent image-guided inguinal sentinel lymph node biopsy in vulvar cancer

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