Diagnostic value of high-sensitivity troponin T in postmortem diagnosis of sudden cardiac death

Zribi, M.; Ennouri, H.; Turki, Mouna; Amar, W. Ben; Grati, Malek; Hammami, Z.; Ayadi, Fatma; Maatoug, S.

doi:10.1016/j.jflm.2021.102127

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…A recent meta-analysis, which included 11 studies examining the levels of Hs-TnT and cardiovascular risk, concluded that it has a strong predictive value for both all-cause and cardiovascular mortality risk in the general population [ 114 ]. Hs-TnT can also be analyzed postmortem from a pericardial fluid sample, making an essential contribution in the diagnosis of sudden cardiac death, without the installation of specific macroscopic changes [ 115 ].…”

Section: Resultsmentioning

confidence: 99%

Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review

Isailă,

Moroianu,

Hostiuc

2024

Medicina

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Background and Objectives: Sudden cardiac death (SCD) represents a challenge to health systems globally and is met with increased frequency in the population. Over time, multiple screening methods have been proposed, including the analysis of various plasma biomarkers. This article aims to analyze for illustrative purposes the specialized literature in terms of current biomarkers and testing trends, in the case of cardiovascular diseases and implicitly sudden cardiac death. Materials and Methods: In this regard, we searched the PubMed database from 2010 to the present time using the keywords “sudden cardiac death” and “biomarkers”. The inclusion criteria were clinical trials that analyzed the effectiveness of screening methods in terms of biomarkers used in stratifying the risk of cardiac distress and/or sudden cardiac death. We excluded reviews, meta-analyses, and studies looking at the effectiveness of treatments. Results: An extended approach was found, through studies that brought to the forefront both classical markers analyzed by new, more performant methods, markers for other pathologies that also determined cardiovascular impact, non-specific molecules with effects on the cardiovascular system, and state-of-the-art markers, such as microRNA. Some molecules were analyzed simultaneously in certain groups of patients. Conclusion: The observed current trend revealed the tendency to define the clinical-biological particularities of the person to be screened.

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Section: Resultsmentioning

confidence: 99%

Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review

Isailă,

Moroianu,

Hostiuc

2024

Medicina

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“…The authors’ strategy was to compare the measurement of the marker in different post-mortem body fluids i.e., pericardial fluid, cardiac blood, and peripheral blood. The authors showed a significant correlation with better sensitivity (75%) and specificity (64%) using pericardial fluid as the reference biological fluid and using a cut-off level of 17.72 ng/mL [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Sacco,

Gualtieri,

Calanna

et al. 2023

IJMS

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Sudden cardiac death (SCD) represents a global emergency, with a high number of cases affecting all age groups every year. The prevention of these fatal events requires an accurate knowledge of etiology and pathogenesis, which can vary. Autopsy is an indispensable tool in cases of SCD for diagnostic purposes, as well as for judicial and preventive purposes for family members. Despite the completion of all routine post-mortem investigations, it is often complicated for the forensic pathologist to define the triggering cause of these events. The study of the proteome is proving to be extremely promising in the field of human cardiovascular disease. This paper aims to offer a literature review on the study of the proteome in post-mortem cadaveric biological samples obtained from SCD cases. The aim of this work is to outline the state of the art of the scientific advances that protein analysis can offer in the diagnosis of SCD and the limits that various studies have traced up to now. In conclusion, the work defines the future perspectives of this field in SCD, suggesting strategies to overcome the reported limits and improve the diagnostics of these events.

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“…There are no specific markers in the postmortem interval effect [12]. In some studies, high-sensitivity troponin-T and tryptophan metabolites are still considered reliable diagnostic tests for sudden cardiac death [13,14].…”

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confidence: 99%

Postmortem Alteration of Purine Metabolism in Coronary Artery Disease

Somtua,

Jaikang,

Konguthaithip

et al. 2023

Metabolites

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A new approach for assisting in the diagnosis of coronary artery disease (CAD) as a cause of death is essential in cases where complete autopsy examinations are not feasible. The purine pathway has been associated with CAD patients, but the understanding of this pathway in postmortem changes needs to be explored. This study investigated the levels of blood purine metabolites in CAD after death. Heart blood samples (n = 60) were collected and divided into CAD (n = 23) and control groups (n = 37). Purine metabolites were measured via proton nuclear magnetic resonance. Guanosine triphosphate (GTP), nicotinamide adenine dinucleotide (NAD), and xanthine levels significantly decreased (p < 0.05); conversely, adenine and deoxyribose 5-phosphate levels significantly increased (p < 0.05) in the CAD group compared to the control group. Decreasing xanthine levels may serve as a marker for predicting the cause of death in CAD (AUC = 0.7). Our findings suggest that the purine pathway was interrupted by physiological processes after death, causing the metabolism of the deceased to differ from that of the living. Additionally, xanthine levels should be studied further to better understand their relationship with CAD and used as a biomarker for CAD diagnosis under decomposition and skeletonization settings.

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Diagnostic value of high-sensitivity troponin T in postmortem diagnosis of sudden cardiac death

Cited by 7 publications

References 37 publications

Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review

Current Trends in Biohumoral Screening for the Risk of Sudden Cardiac Death: A Systematic Review

Exploring the Potential of Proteome Analysis as a Promising Tool for Evaluation of Sudden Cardiac Death (SCD) in Forensic Settings: A Literature Review

Postmortem Alteration of Purine Metabolism in Coronary Artery Disease

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