Diagnostic Value of HbA1c Level in Behcet’s Disease and Evaluation of Neutrophil-Lymphocyte Ratio, Mean Platelet Volume and Body Mass Index

Pancar, Gunseli Sefika; Kalkan, Göknur

doi:10.14740/jh230e

Cited by 5 publications

(15 citation statements)

References 18 publications

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“…The findings of our study are consistent with the literature as white blood cell, platelet, and neutrophil counts and RDW were significantly higher in the active BD group compared with the inactive BD group. In parallel with these findings, other inflammatory markers such as ESR, CRP and ferritin levels were also significantly higher in the active BD group 10–18 …”

Section: Discussionsupporting

confidence: 61%

“…conducted a retrospective study evaluating NLR and MPV in patients with active BD ( n = 120), inactive BD ( n = 66) and healthy controls ( n = 79), and reported higher rates of NLR in the active BD group compared with the other groups 15 . Similarly, Pancar and Kalkan reported significantly higher NLR values in the BD group ( n = 64) compared with the control group ( n = 64) in their retrospective study 16 . Another study by Yolbas et al .…”

Section: Discussionmentioning

confidence: 95%

“…Various FBC indices have been used in the literature for the evaluation of BD 10–18 . In their retrospective study, Alan et al .…”

Section: Discussionmentioning

confidence: 99%

“…Its retrospective design, relatively low number of cases and heterogeneity in the study populations were the main limitations. Additionally, FBC indices may be affected by various factors such as anaemia, thrombocytopenia and acute infection 10–18 . Physicians should consider these factors in the assessment of inflammation with FBC indices.…”

Section: Discussionmentioning

confidence: 99%

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A cutoff value for the Systemic Immune‐Inflammation Index in determining activity of Behçet disease

et al. 2020

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Summary Background Behçet disease (BD) is an immune‐mediated vasculitis‐like syndrome characterized by recurrent aphthous lesions and various systemic manifestations. Inflammatory markers may be useful to assess disease severity. The Systemic Immune‐Inflammation Index (SII) (neutrophils × platelets/lymphocytes) has been widely used in oncology since 2014, with promising results. Aim To assess the efficiency of the SII in determining activity of BD. Methods This retrospective cohort study was conducted on patients with BD who were admitted to the outpatient clinic of the Department of Dermatology and Venereology, Ufuk University Hospital, between 1 January 2010 and 31 December 2019. Patients were divided into two groups based on their disease status upon admission: (i) active BD (n = 103), and (ii) inactive BD (n = 63). Clinical characteristics, demographic features, type of medications, full blood count parameters, erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), ferritin and SII were compared between the groups. Furthermore, receiver operating characteristic curve analysis was performed to assess the performance of the SII in determining disease severity upon admission to hospital. Results Higher numbers of white blood cells, platelets and neutrophils, greater red cell distribution width, higher levels of ESR, CRP and ferritin, and higher SII were observed in the active disease group (P < 0.001). The cutoff value of 552 × 103/mm3 was found to have 81% sensitivity and 82% specificity. Conclusion The SII may be used as an additional indicator for the assessment of BD status and physicians should be cautious in patients with SII levels of > 552 × 103/mm3) at the initial evaluation of the patients.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 95%

“…Various FBC indices have been used in the literature for the evaluation of BD 10–18 . In their retrospective study, Alan et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A cutoff value for the Systemic Immune‐Inflammation Index in determining activity of Behçet disease

et al. 2020

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“…In our study, there were statistically insignificant differences (P> 0.05) regarding WBCs, statistically significant differences (P< 0.05) regarding lymphocytes count and NLR, and a highly statistically significant difference (P< 0.001) regarding neutrophil count, being higher in patients with BD than healthy control group. These results go hand in hand with the studies by Ozturk et al [14] and Pancar and Kalkan [16]. They concluded that higher NLR may be related to endothelial dysfunction (ED) and may reflect disease activity in patients with BD.…”

Section: Resultsmentioning

confidence: 71%

Neutrophil-to-lymphocyte ratio: relation to disease activity and carotid intima-media thickness in Behçet’s disease

Elden

Hmmad

Farouk

et al. 2018

Egypt Rheumatol Rehabil

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Background Behçet's disease (BD) is an autoinflammatory disorder. Disease activity could be detected by changes in peripheral blood cell components. The aim of this study was to assess the relationship between neutrophil-to-lymphocyte ratio (NLR) with disease activity and carotid intima-media thickness (cIMT) in patients with BD. Patients and methods This study was conducted on 20 adult patients with BD (group І). This group was subdivided according to cIMT into group Іa, which included patients with increased cIMT, and group Іb, which included patients with cIMT within normal ranges. Moreover, 20 age-matched and sex-matched apparently healthy volunteers were included as a control group (group ІІ). Patients with BD were subjected to full history taking, thorough clinical examination, and assessment of disease activity according to Behçet's Disease Current Activity Form score. The white blood cell count, neutrophil count, and lymphocytes count were recorded, and NLR was calculated. cIMT assessment was done for all participants. Results There were statistically significant differences (P< 0.05) regarding lymphocytes count and NLR and highly statistically significant difference (P< 0.001) regarding neutrophil count, being higher in patients with BD. There was a statistically highly significant difference (P< 0.001) regarding cIMT, being higher in group Іa patients (0.82±0.03) than group Іb patients (0.50±0.04) and healthy control group (0.47 ±0.04). There was a statistically significance positive correlation (R=639, P=0.005) between NLR and Behçet's Disease Current Activity Form score. In conclusion, higher NLR values were recorded in patients with BD. Furthermore, patients with active BD had higher NLR values than inactive, and NLR is higher in patients with increased cIMT; thus, NLR may be an important bio-index for detecting BD activity and the presence of vascular affection.

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Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet’s disease

Park

et al. 2023

Arthritis Res Ther

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Background Behçet’s disease (BD) is a systemic inflammatory disease that involves various organs. The clinical manifestation-based diagnosis of BD is a time-consuming process, which makes it difficult to distinguish from patients with similar symptoms. Moreover, an authentic biomarker has not been developed for accurate diagnosis yet. Our current study investigated the unique metabolic signatures of BD and explored biomarkers for precise diagnosis based on an untargeted metabolomic approach. Methods Integrative metabolomic and lipidomic profiling was performed on plasma samples of BD patients (n = 40), healthy controls (HCs, n = 18), and disease controls (DCs, n = 17) using GC-TOF MS and LC-Orbitrap MS. Additionally, the lipid profiles of 66 peripheral blood mononuclear cells (PBMCs) were analyzed from 29 BD patients, 18 HCs, and 19 DCs. Results Plasma metabolic dysfunction in BD was determined in carbohydrate, hydroxy fatty acid, and polyunsaturated fatty acid metabolisms. A plasma biomarker panel with 13 compounds was constructed, which simultaneously distinguished BD from HC and DC (AUCs ranged from 0.810 to 0.966). Dysregulated PBMC metabolome was signatured by a significant elevation in lysophosphatidylcholines (LPCs) and ether-linked lysophosphatidylethanolamines (EtherLPEs). Ten PBMC-derived lipid composites showed good discrimination power (AUCs ranged from 0.900 to 0.973). Correlation analysis revealed a potential association between disease activity and the metabolites of plasma and PBMC, including sphingosine-1 phosphate and EtherLPE 18:2. Conclusions We identified metabolic biomarkers from plasma PBMC, which selectively discriminated BD from healthy control and patients with similar symptoms (recurrent mouth ulcers with/without genital ulcers). The strong correlation was determined between the BD activity and the lipid molecules. These findings may lead to the development for diagnostic and prognostic biomarkers based on a better understanding of the BD pathomechanism.

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Diagnostic Value of HbA1c Level in Behcet’s Disease and Evaluation of Neutrophil-Lymphocyte Ratio, Mean Platelet Volume and Body Mass Index

Cited by 5 publications

References 18 publications

A cutoff value for the Systemic Immune‐Inflammation Index in determining activity of Behçet disease

A cutoff value for the Systemic Immune‐Inflammation Index in determining activity of Behçet disease

Neutrophil-to-lymphocyte ratio: relation to disease activity and carotid intima-media thickness in Behçet’s disease

Integrative metabolomics of plasma and PBMCs identifies distinctive metabolic signatures in Behçet’s disease

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