Diagnostic value of galectin‐3 as a marker for malignancy in follicular patterned thyroid lesions

Oestreicher‐Kedem, Yael; Halpern, Marisa; Roizman, Pepi; Hardy, Britta; Sulkes, Jaqueline; Feinmesser, Raphael; Stern, Yoram

doi:10.1002/hed.20087

Cited by 46 publications

(38 citation statements)

References 29 publications

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“…However, data from us and other laboratories show that galectin-3 test method works well also in follicular carcinomas (Bartolazzi et al, 2001;Oestreicher-Kedem et al, 2004;Collet et al, 2005;Papotti et al, 2005;Saggiorato et al, 2005). By the practical point of view, the incidence of well-differentiated follicular carcinomas is low (less than 10% of the cases) and is markedly reduced in countries without iodine deficiency.…”

Section: Discussionmentioning

confidence: 92%

Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology

et al. 2006

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Thyroid fine-needle aspiration biopsy (FNA)-cytology is widely used for the preoperative characterisation of thyroid nodules but this task is difficult for follicular lesions, which often remain undefined. We propose a strategy for improving the preoperative characterisation of selected follicular thyroid proliferations, which is based on large needle aspiration biopsy (LNAB) and galectin-3 expression analysis. Eighty-five thyroid specimens were obtained by LNAB (20-gauge needles) from thyroid nodules with indeterminate follicular FNA-cytology. Aspirated material was processed as a tissue microbiopsy to obtain cell blocks for both cyto/ histo-morphological evaluation and galectin-3 expression analysis, by using a purified monoclonal antibody to galectin-3 and a biotinfree immunoperoxidase staining method. Preoperative diagnosis was compared to the final histology. LNAB and cell-block technique allow a preliminary distinction between nodules with a homogeneous microfollicular/trabecular structure, as frequently observed in tumours, and lesions with mixed normo -micro -macrofollicular architecture, as observed in goitre. Furthermore, LNAB provides optimal substrates for galectin-3 expression analysis. Among 85 cases tested, 14 galectin-3-positive cases were discovered preoperatively (11 thyroid cancers and three adenomas confirmed at the final histology), whereas galectin-3-negative cases were 71 (one carcinoma and 70 benign proliferations at the final histology). Sensitivity, specificity and diagnostic accuracy of this integrated morphologic and phenotypic diagnostic approach were 91.6, 97.2 and 95.3%, respectively. In conclusion, LNAB plus galectin-3 expression analysis when applied preoperatively to selected thyroid nodules candidate to surgery can potentially reduce unnecessary thyroid resections.

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Section: Discussionmentioning

confidence: 92%

Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology

et al. 2006

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“…There has been some controversial results with studies showing galectin-3 to be a very interesting marker of malignancy (Orlandi et al, 1998;Saggiorato et al, 2001;Nascimento et al, 2001;Oestreicher-Kedem et al, 2004), including molecular profiling studies of follicular thyroid lesions (Finley et al, 2004) and others reporting that galectin-3 cannot discriminate benign from malignant thyroid lesions (Mehrotra et al, 2004;Mills et al, 2005). The reasons for this discrepancy might be related to differences in technical procedures, in the type of thyroid lesions analysed and to insufficient number of samples tested.…”

Section: Discussionmentioning

confidence: 99%

Galectin-3 immunodetection in follicular thyroid neoplasms: a prospective study on fine-needle aspiration samples

et al. 2005

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Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirates classified as undeterminate by cytology. After establishing an easy processing of aspirates for galectin-3 immunodetection, a series of aspirates categorised as benign (n ¼ 63), malignant (n ¼ 17) or undeterminate (n ¼ 34) was prospectively analysed for galectin-3. Only the patients with malignant or undeterminate lesions underwent surgery. Most lesions (86%) diagnosed as malignant by cytology or after surgery were positive for galectin-3. The majority of lesions (94%) classified as benign by cytology or after surgery was negative for galectin-3. The positive and negative predictive values were 83 and 95%, respectively. When focusing on the undeterminate lesions, the sensitivity and specificity were 75 and 90%, respectively, while the positive and negative predictive values were 82 and 87%, respectively. The specificity and the positive predictive value were higher (100%) when considering the percentage of stained cells. Altogether these results show that galectin-3 constitutes a useful marker in the diagnosis of thyroid lesions classified as undeterminate by conventional cytology.

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“…Oestreicher-Kedem et al (31) have stated that Galectin-3 expression in Hurthle cell proliferation or in minimally invasive follicular carcinomas may lead to problems in diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Serum Galectin-3: diagnostic value for papillary thyroid carcinoma

Yılmaz¹,

Karsidag²,

Tatar³

et al. 2015

UCD

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Objective: Thyroid cancer constitutes approximately 1% of all cancers, approximately 90% of the endocrine malignancies, and is responsible for 0.4% of cancer-related deaths. Additional markers are required for the accurate diagnosis of thyroid malignancies. There is no marker that can accurately facilitate pre-operative benign-malignant differentiation of thyroid nodules. The present study aims to evaluate the diagnostic value of preoperative serum Galectin-3 levels in thyroid cancer and to avoid unnecessary aggressive interventions. Material and Methods:Sixty-four patients who were operated between May 2009 and April 2011 were included in this study prospectively. Patients with toxic nodules and those with malignancies detected in preoperative fine needle aspiration biopsies (FNAB) were excluded. Patients with thyroid nodules of >3 cm in ultrasonography or having suspicious cytological findings in their preoperative FNABs regardless of the nodule size were included. Patients were divided into 2 groups, "control"and "cancer," according to the postoperative pathology results. Results:The control group included 50 and cancer group included 14 patients. The mean age of the control group was 44.84±13

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Diagnostic value of galectin‐3 as a marker for malignancy in follicular patterned thyroid lesions

Abstract: Galectin-3 staining is highly sensitive for malignancy in follicular patterned thyroid lesions. Diagnostic problems may arise in the presence of Hurthle cell proliferation or minimally invasive follicular carcinoma.

Cited by 46 publications

References 29 publications

Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology

Large needle aspiration biopsy and galectin-3 determination in selected thyroid nodules with indeterminate FNA-cytology

Galectin-3 immunodetection in follicular thyroid neoplasms: a prospective study on fine-needle aspiration samples

Serum Galectin-3: diagnostic value for papillary thyroid carcinoma

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