Diagnostic value of gadolinium-enhanced dynamic MR imaging for parotid gland tumors

Shahat, Hazem Mohamed El; Fahmy, Hadeer Safwat; Gouhar, Ghada K.

doi:10.1016/j.ejrnm.2013.02.007

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…DCE-MRI can reveal haemodynamic information, and the effectiveness for distinguishing between benign and malignant salivary gland tumours has been confirmed by some studies. [20][21][22][23] Hisatomi et al 21 and Yabuuchi et al 23 found that DCE-MRI parameters and TIC patterns were useful in the differential diagnosis of salivary gland tumours based on the combined assessment of TTP and WR. Both studies 21,23 indicated that a TTP of 120 s allowed for the differentiation of a malignant carcinoma from a benign pleomorphic adenoma but not from a Warthin's tumour, whereas a WR of 30% enabled the differentiation between a malignant tumour and a Warthin's tumour.…”

Section: Discussionmentioning

confidence: 99%

“…The usefulness of dynamic contrast-enhanced (DCE)-MRI parameters and the high diagnostic value of the time-intensity curve (TIC) derived from DCE-MRI have been well documented in previous studies. [19][20][21][22][23] Recently, DCE-MRI has been used in combination with DWI for analyzing parotid gland tumours and has been shown to have a higher diagnostic value. 24,25 However, there are only a few reports for assessing the value of combining conventional MRI with DWI and DCE-MRI for determining the characteristics of parotid gland tumours.…”

Section: Introductionmentioning

confidence: 99%

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The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours

Tao

Yang

Wang

et al. 2017

Dentomaxillofacial Radiology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours

Tao

Yang

Wang

et al. 2017

Dentomaxillofacial Radiology

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“…Among the neoplasms arising in the salivary glands, the parotid gland tumors are the most common with a frequency about 80 % [ 1 , 2 ]. The accurate preoperative diagnosis of the parotid gland tumors is very essential and important clinically, because the discrimination between the benign and malignant tumors influences the following management of the optimal surgical procedures [ 2 , 3 ]. Unfortunately, the routine biopsy is not recommended in the parotid gland tumors due to the possibility of the implantation metastasis and facial nerve injury [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Label-free blood serum detection by using surface-enhanced Raman spectroscopy and support vector machine for the preoperative diagnosis of parotid gland tumors

Yan

Wen

et al. 2015

BMC Cancer

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BackgroundIt is difficult for the parotid gland neoplasms to make an accurate preoperative diagnosis due to the restriction of biopsy in the parotid gland neoplasms. The aim of this study is to apply the surface-enhanced Raman spectroscopy (SERS) method for the blood serum biochemical detection and use the support vector machine for the analysis in order to develop a simple but accurate blood serum detection for preoperative diagnosis of the parotid gland neoplasms.MethodsThe blood serums were collected from four groups: the patients with pleomorphic adenoma, the patients with Warthin’s tumor, the patients with mucoepidermoid carcinoma and the volunteers without parotid gland neoplasms. Au nanoparticles (Au NPs) were mixed with the blood serum as the SERS active nanosensor to enhance the Raman scattering signals produced by the various biochemical materials and high quality SERS spectrum were obtained by using the Raman microscope system. Then the support vector machine was utilized to analyze the differences of the SERS spectrum from the blood serum of different groups and established a diagnostic model to discriminate the different groups.ResultsIt was demonstrated that there were different intensities of SERS peaks assigned to various biochemical changes in the blood serum between the parotid gland tumor groups and normal control group. Compared with the SERS spectra of the normal serums, the intensities of peaks assigned to nucleic acids and proteins increased in the SERS spectra of the parotid gland tumor serums, which manifested the differences of the biochemical metabolites in the serum from the patients with parotid gland tumors. When the leave-one-sample-out method was used, support vector machine (SVM) played an outstanding performance in the classification of the SERS spectra with the high accuracy (84.1 % ~ 88.3 %), sensitivity (82.2 % ~ 97.4 %) and specificity (73.7 % ~ 86.7 %). Though the accuracy, sensitivity and specificity decreased in the leave-one-patient-out cross validation, the mucoepidermoid carcinoma was still easier to diagnose than other tumors.DiscussionThe specific molecular differences of parotid gland tumors and normal serums were significantly demonstrated through the comparison between the various SERS spectra.But compared with the serum SERS spectra reported in the other studies, some differences exist between the spectra in this study and the ones reported in the lietratures. These differences may result from the various nano-particles, the different preparation of serum and equipment parameters, and we could need a further research to find an exact explanation.Based on the SERS spectra of the serum samples, SVM have shown a giant potential to diagnose the parotid gland tumors in our preliminary study. However, different cross validaiton methods could effect the accuracy and a further study involing a great number of samples should be needed.ConclusionsThis exploratory research demonstrated the great potential of SERS combined with SVM into a non-invasive clinical diagnostic meth...

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“…This is similar to a WT, yet the enhancement pattern can be used to differentiate the entities. Solid portions of BCAs are intensely enhanced on fat-suppressed contrast-enhanced T1 images, whereas WTs are only mildly so [37,38]. Few studies have focused on the role of DWI in depicting the basal adenoma and found mean ADC values of 1.24 ± 0.18 × 10 −3 mm 2 /s) [7].…”

Section: Basal Cell Adenomamentioning

confidence: 99%

Beyond Ultrasound: Multimodal Cross-Sectional Imaging for Preoperative Imaging of Parotid Gland Tumors: A Primer for Radiology Trainees

Mahmoud,

Mahdi,

Ahsan

et al. 2024

JOHBM

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Even if the management of parotid gland tumors depends on the histopathological subtype, preoperative imaging of parotid gland tumors is clinically relevant. Preoperative imaging gives insight into the differentiation between benign and malignant tumors, which might potentially decrease the number of unnecessary aggressive surgeries. Characteristic imaging findings on cross-sectional imaging, such as computed tomography (CT) and magnetic resonance imaging (MRI), can help narrow the differential diagnosis and guide the further management of patients presenting with parotid masses. While MRI is imperative for the determination of perineural spread, which is frequently encountered with malignant parotid tumors, CT is important for the evaluation of osseous invasion. Furthermore, multi-parametric MRI protocols provide insights into the tumor behavior and internal composition, which is helpful in the case of benign mixed tumors and others. While distant metastasis is uncommon with parotid neoplasms, PET/CT provides a valuable tool for the improved evaluation of loco-regional and distant metastatic disease. This article discusses the imaging features of common benign and malignant parotid tumors.

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Diagnostic value of gadolinium-enhanced dynamic MR imaging for parotid gland tumors

Cited by 9 publications

References 18 publications

The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours

The value of combining conventional, diffusion-weighted and dynamic contrast-enhanced MR imaging for the diagnosis of parotid gland tumours

Label-free blood serum detection by using surface-enhanced Raman spectroscopy and support vector machine for the preoperative diagnosis of parotid gland tumors

Beyond Ultrasound: Multimodal Cross-Sectional Imaging for Preoperative Imaging of Parotid Gland Tumors: A Primer for Radiology Trainees

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