Diagnostic value of Flash dual-source CT coronary artery imaging combined with dual-energy myocardial perfusion imaging for coronary heart disease

Abstract

The present study aimed to investigate the diagnostic value of Flash dual-source CT coronary angiography (DS-CTA) combined with dual-energy myocardial perfusion imaging (DS-CTP) for coronary heart disease (CHD), as a single-stage examination. A total of 60 patients with CHD underwent DS-CT examination, as well as coronary angiography (CAG), as the reference standard. The patients were divided into <50% and ≥50% stenosis groups based on their coronary angiograms. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the method for diagnosing stenosis of ≥50% were evaluated via DS-CTA combined with DS-CTP. Of the 60 patients, 59 showed satisfactory results that conformed to the diagnostic requirements. Using CAG as the reference standard, the sensitivity, specificity and positive and negative predictive values of the Flash DS-CT results in the ≥50% vascular stenosis group were 83.7, 92.7, 88.9 and 89.1%, respectively. The respective values for DS-CTA combined with DS-CTP for diagnosing CHD were 94.2, 91.1, 88.0 and 95.8%. Therefore, the results obtained indicate that DS-CTA combined with DS-CTP has a high diagnostic value for CHD. DS-CT is advantageous for diagnosing and prognosticating CHD.

Low-dose ultra-high-pitch computed tomography coronary angiography: identifying the optimum combination of iteration strength and radiation dose reduction strategies to achieve true submillisievert scans

“…Nearly all unnecessary radiation exposure is eliminated in the FLASH CTCA occurring only at the commencement and end of the scanned volume. With a pitch of 3.4, a time resolution of 75 msec and full heart coverage in < 0.25 sec, Flash CTCA has a reported success rate of 100% in the delineation of coronary arteries up to 1.5 mm (12). FLASH-CTCA is, therefore, an acceptable angiographic method for reducing radiation dose without compromising image quality.…”

“…With a pitch of 3.4, time resolution of 75 ms, and full heart coverage in <0.25 s, FLASH CTCA has a reported success rate of 100% in the delineation of coronary arteries up to 1.5 mm. 12 FLASH CTCA is, therefore, an acceptable angiographic method for reducing radiation dose without compromising image quality. The challenge with using FLASH CTCA is that it requires a stable and low HR.…”

The dream of a one-stop-shop: Meta-analysis on myocardial perfusion CT

“…Interestingly, the combination of single-phase stress CT with CTA provided even better diagnostic accuracy in several studies, which makes combination of these techniques into one scan examination promising for future patient workup [22,[36][37][38].…”

COVID-19-related cardiomyopathy: Can dual-energy computed tomography be a diagnostic tool?

“…When different energy levels of X-ray spectra penetrate through iodine-based contrast medium, each reveals unique absorption characteristics. Iodine mapping (plotting of the distribution of iodine in the myocardium) can be used to precisely detect cardiac perfusion deficits; for example, dark areas in a map indicate a lack of iodine and correlate to areas of low myocardial perfusion[ 10 , 12 , 13 ].…”