Diagnostic value of fibroblast growth factor 23 for abdominal aortic calcification in Indonesian hemodialysis patients

Muzasti, Riri Andri; Lubis, Netty Delvrita

doi:10.4103/tcmj.tcmj_2_20

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…This table also observed the high value of sensitivity and specificity of the FGF23 with 100% and 100% respectively, with 95% confidence with (p-value≤0.001). [21] reported that the threshold value for FGF23 was 277 pg/mL and that patient serum levels were much higher. The calculated area under the ROC curves was 0.959; the calculated sensitivity and specificity were 94.0 percent and 84.0 percent, respectively (P< 0.001).…”

Section: Resultsmentioning

confidence: 99%

Association of Fibroblast Growth Factor 23 and Calcium in Chronic Kidney Disease Patients

Kamil

Hussein

Maroof

2022

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Chronic kidney disease (CKD) is a growing international health concern with elevating mortality rate in the world today and it is generally a progressive and irreversible issue. It is defined by changes in kidney shape, function, or both lasting at least three months. Renal disease is commonly associated with Abnormalities of minerals and electrolyte. Levels of Ca change and the FGF23 increase early in CKD. This study was designed to show the Correlation between FGF23 and Ca in chronic kidney disease patients. One hundred blood samples (57males and 43 females) from CKD patients have been gathered from Al-Yarmouk Teaching Hospital, Baghdad Teaching Hospital and Al-Karama Teaching Hospital during the period from December 2021 to March 2022 besides 50 samples as apparently healthy control. The age range in the current study was at 33-75 years for CKD patient and 30-65 years for control. The fibroblast growth factor 23 was screened by an ELISA method and serum Calcium, by cobas c111 analyze. Ca, FGF23 is statistically highly significant at p-value =0.001. The receiver operation characteristic (ROC) curve results revealed that the sensitivity and specificity for FGF23 was 100%. The conclusion of the current study shows that the. FGF 23 was high in all CKD patients and Ca was high in two patients, normal in thirty-seven patients, and decreased in sixty-one patients.

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Section: Resultsmentioning

confidence: 99%

Association of Fibroblast Growth Factor 23 and Calcium in Chronic Kidney Disease Patients

Kamil

Hussein

Maroof

2022

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“…exhibited signi cantly higher serum FGF23 levels compared to those without such calci cation [15] . However, the signi cance of elevated FGF23 in peritoneal dialysis (PD) patients is less understood, with fewer studies, particularly those related to coronary artery calci cation (CAC).…”

Section: Declarationsmentioning

confidence: 94%

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

Xie,

Si,

Wang

et al. 2024

Preprint

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Background This research investigates the correlation between serum fibroblast growth factor 23 (FGF23) levels and vascular calcification in individuals undergoing peritoneal dialysis (PD). Methods The study period spanned from January 2021 to August 2023, 220 patients receiving peritoneal dialysis at our hospital were selected as participants. FGF23 concentrations were determined through an enzyme-linked immunosorbent assay (ELISA), and coronary multi-slice spiral computed tomography (CT) and upright abdominal X-ray examinations were conducted to evaluate calcification scores. The relationship between FGF23 levels and vascular calcification in PD patients was analyzed. Results FGF23 levels were significantly positively correlated with coronary artery calcification (CAC), abdominal aortic calcification (AAC), brachial-ankle pulse wave velocity (baPWV), and high-sensitivity C-reactive protein (CRP). When patients were stratified by coronary calcification scores, there was statistical difference in FGF23 levels between the mild-to-moderate calcification group and the non-calcification group, significant differences were observed between the mild-to-moderate calcification group and the severe calcification group, as well as between the non-calcification group and the severe calcification group. Similarly, significant differences in FGF23 levels were observed among groups stratified by abdominal aortic calcification scores, with FGF23 levels significantly increasing with the severity of calcification. The diagnostic efficacy of FGF23 levels in detecting coronary artery calcification was assessed using a receiver operating characteristic (ROC) curve analysis, yielding a sensitivity of 61.35% and a specificity of 73.68%. Similarly, for abdominal aortic calcification, the ROC curve analysis revealed a sensitivity of 58.9% and a specificity of 69.57%. Conclusion The study concludes that serum FGF23 levels are linked to coronary artery calcification in PD patients and can be utilized as a supplementary indicator for diagnosing this condition.

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Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

Wungu,

Susilo,

Alsagaff

et al. 2024

Sci Rep

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This meta-analysis was conducted to clarify the role of klotho and fibroblast growth factor 23 (FGF-23) in human arterial remodeling across recent studies, in terms of arterial calcification, thickness, and stiffness. A systematic literature search was conducted on five databases for articles up to December 2023. Arterial calcification, thickness, and stiffness were determined using the calcification score and artery affected, carotid intima–media thickness (CIMT), and pulse wave velocity (PWV), respectively. Sixty-two studies with a total of 27,459 individuals were included in this meta-analysis. Most studies involved chronic kidney disease patients. Study designs were mostly cross-sectional with only one case–control and nine cohorts. FGF-23 was positively correlated with arterial calcification (r = 0.446 [0.254–0.611], p < 0.0001 and aOR = 1.36 [1.09–1.69], p = 0.006), CIMT (r = 0.188 [0.02–0.354], p = 0.03), and PWV (r = 0.235 [0.159–0.310], p < 0.00001). By contrast, Klotho was inversely correlated with arterial calcification (r = − 0.388 [− 0.578 to − 0.159], p = 0.001) and CIMT (r = − 0.38 [− 0.53 to − 0.207], p < 0.00001). In conclusion, FGF-23 and Klotho were associated with arterial calcification, thickness, and stiffness, clarifying their role in arterial remodeling processes.

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Diagnostic value of fibroblast growth factor 23 for abdominal aortic calcification in Indonesian hemodialysis patients

Cited by 3 publications

References 23 publications

Association of Fibroblast Growth Factor 23 and Calcium in Chronic Kidney Disease Patients

Association of Fibroblast Growth Factor 23 and Calcium in Chronic Kidney Disease Patients

The Role of Fibroblast Growth Factor 23 in Vascular Calcification in Peritoneal Dialysis Patients

Role of klotho and fibroblast growth factor 23 in arterial calcification, thickness, and stiffness: a meta-analysis of observational studies

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