Diagnostic Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Detecting Residual or Recurrent Prostate Cancer After Radical Prostatectomy: A Pooled Analysis of 12 Individual Studies

Yu, Tao; Meng, Nan; Chi, Da; Zhao, Yupei; Wang, Zhekun; Luo, Yahong

doi:10.1007/s12013-015-0519-6

Cited by 10 publications

(2 citation statements)

References 26 publications

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“…Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) criteria were evaluated to determine the quality of included studies [12,13]. The QUADAS identifies 4 key domains – “patient selection”, “index test”, “reference standard”, and “flow and timing” – which are combined to assess the risk of bias.…”

Section: Methodsmentioning

confidence: 99%

Accuracy of C-Reactive Protein Test for Neonatal Septicemia: A Diagnostic Meta-Analysis

Liu

Zhao

2019

Med Sci Monit

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Background The aim of this study was to evaluate the diagnostic value of C-reactive protein (CRP) test in detecting neonatal septicemia. Material/Methods We searched the Cochrane Library, PubMed, Springer, MBASE, Elsevier Science Direct, and Medline databases up to March 2017. To collect relevant data on CRP testing in patients with neonatal septicemia, we performed a meta-analysis of positive likelihood ratio (LR), sensitivity, negative LR, specificity and diagnostic odds ratio (dOR) of CRP testing, using Stata 12.0 and Meta-DiSc 1.4 data analysis software. Results Ten studies including 1819 participants were considered in this study. We found that positive LR, sensitivity, negative LR, specificity, and dOR of the CRP test for neonatal septicemia were 5.63 (95% CI=2.86 to 11.09), 0.70 (95% CI=0.66 to 0.75), 0.36 (95% CI=0.21 to 0.60), 0.89 (95% CI=0.87 to 0.91), and 17.99 (95% CI=6.50 to 49.83), respectively. The AUC and Q* index of this meta-analysis were 0.90 and 0.83, respectively. Conclusions The area under the curve (AUC), negative LR, positive LR, Q* index, specificity, and dOR of the CRP test suggest that it is appropriate for detecting neonatal septicemia.

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Section: Methodsmentioning

confidence: 99%

Accuracy of C-Reactive Protein Test for Neonatal Septicemia: A Diagnostic Meta-Analysis

Liu

Zhao

2019

Med Sci Monit

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“…Eight out of 10 biopsies were positive for local recurrence [114]. In a pooled analysis by Yu et al, the pooled sensitivity and specificity for dynamic contrast-enhanced MRI in detecting residual or recurrent disease following prostatectomy was 0.88 and 0.87, respectively, in the 12 studies reviewed [115]. In most studies, patients with positive MRI findings had higher PSA levels [113].…”

Section: Role Of Mri Following Radical Prostatectomy To Identify Locomentioning

confidence: 99%

Improving postoperative radiotherapy following radical prostatectomy

Lipman

Pieters

Reijke

2017

Expert Review of Anticancer Therapy

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Prostate cancer has one of the highest incidences in the world, with good curative treatment options like radiotherapy and radical prostatectomy. Unfortunately, about 30% of the patients initially treated with curative intent will develop a recurrence and need adjuvant treatment. Five randomized trials covered the role of postoperative radiotherapy after radical prostatectomy, but there is still a lot of debate about which patients should receive postoperative radiotherapy. Areas covered: This review will give an overview on the available literature concerning post-operative radiotherapy following radical prostatectomy with an emphasis on the five randomized trials. Also, new imaging techniques like prostate-specific membrane antigen positron emission tomography (PSMA-PET) and multiparametric magnetic resonance imaging (mp-MRI) and the development of biomarkers like genomic classifiers will be discussed in the search for an improved selection of patients who will benefit from postoperative radiotherapy following radical prostatectomy. With new treatment techniques like Intensity Modulated Radiotherapy, toxicity profiles will be kept low. Expert commentary: Patients with biochemical recurrence following radical prostatectomy with an early rise in prostate-specific antigen (PSA) will benefit most from postoperative radiotherapy. In this way, patients with only high risk pathological features can avoid unnecessary treatment and toxicity, and early intervention in progressing patients would not compromise the outcome.

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