Diagnostic Value of Diffusion-weighted Magnetic Resonance (MR) Imaging, MR Perfusion, and MR Spectroscopy in Addition to Conventional MR Imaging in Intracranial Space-occupying Lesions

Aydın, Zeynep Banu; Aydın, Hasan; Birgi, Erdem; Hekįmoğlu, Baki

doi:10.7759/cureus.6409

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…Importantly, the diagnostic accuracy of MRS in our study was very high (100%), while Aydın et al . [ 19 ] reported an accuracy of 77% of MRS, and they reported diagnostic accuracy of 100% when MRS combined with diffuse weighted imaging (DWI) or perfusion MR (MRP). The strength of this study that MRS performed diagnostic accuracy of 100% without a combination of DWI or MRP.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions

Alshammari

Salih

Gameraddin

et al. 2021

CMIR

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Background: Differentiation of brain lesions by conventional MRI alone is not enough. The introduction of sophisticated imaging methods, such as MR spectroscopy (MRS), will have considered contribution and accuracy to the differentiation. Objective: To determine the diagnostic accuracy of MRS in differentiating neoplasm and non-neoplastic brain lesion. Methodology: This is a cross-sectional descriptive study conducted at Khartoum State from the period of 2015 to 2017. Thirty cases with brain lesions were included in the study investigated with MRS (Single-voxel spectroscopy) and conventional MRI. A comparison of MRS findings and histopathologic analysis was performed. The ratios of Cho/Cr and Cho/NAA were analyzed and compared between neoplastic and non-neoplastic brain masses. Data were analyzed using SPSS version 23. Results: Out of the 30 patients affected with brain lesions, there were 16 females and 14 males with a mean age of 44 +- 18 years. The ratios of Cho/Cr and Cho/NAA were higher in gliomas, astrocytoma, and meningioma than non-neoplastic lesions. Kappa statistical value (K) showed a good agreement between MRS and histopathological analysis (K= 0.60). The diagnostic accuracy of MRS was 100%, with 82.60% sensitivity, 85.71% specificity, 95% PPV, and 60% NPV. Conclusion: MRS has high diagnostic accuracy in differentiating neoplasm from non-neoplastic brain tumors. The elevation ratios of Choline-to- N-acetyl aspartate and choline-to- creatine can help Neurosurgeons and clinicians differentiate benign from malignant masses.

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Section: Discussionmentioning

confidence: 99%

Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions

Alshammari

Salih

Gameraddin

et al. 2021

CMIR

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“…This was agreed by all the members of our multidisciplinary neuro-oncology team and discussed with our ethics board. The scientific literature shows that biosignatures and 3-Tesla MRI with spectroscopic analysis of multiple regions of interest can be highly reliable [3][4][5], but no randomized studies have ever compared their safety and effectiveness versus standardof-care surgical biopsy, and no proof of validity for this approach exists. This said, our approach is in keeping with the preliminary experience and suggestions made by colleagues in the United States and Canada [6][7][8].…”

Section: Our Ethos and Actionsmentioning

confidence: 99%

How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice

et al. 2020

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Role of MRI modalities in assessment of cystic brain Lesions: a prospective study

Beniamin¹,

Elhefnawy²,

Abdelsamad³

et al. 2022

УРОЖ

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Background. Intracranial cystic lesions are unnatural cavities in which the continuity of the brain parenchyma is disrupted because of different pathologies such as infections and tumors containing proteinaceous fluid and/or cellular/necrotic materials. Purpose – to investigate the value of some MRI modalities, mostly DWI and MR spectroscopy, in differentiation of the common intracranial intra-axial cystic brain lesions to help these patients benefit from the best medical management and treatment. Materials and Methods. This is a prospective study, conducted from April 2019 till April 2021. It involved forty adult patients of both sexes with a cystic/necrotic intra-axial brain lesion with variable perifocal edema and rim enhancement on post-contrast study at MRI unit, radiology department, Ain Shams University (ASU) Hospital. All examinations were carried out after signing of the informed consent by the patients themselves or their guardian if the patient was incapacitated by any means. Results. The ADC values in the center of lesions were not uniform. We found the lowest ADC value in the center of the lesion at the abscess 0.4x10–3 mm2 /s, and the highest ADC value 3.2x10–3 mm2 /s was in cystic neoplastic lesion. There was a significant difference in the ADC values in the center of neoplastic necrotic lesions; mean ADC value was (1.95±1.08) x10–3 mm2 /s and (1.15±0.65) x10–3 mm2 /s in abscess lesions, with a cut-off value, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy value of: 1.55%, 92.9%, 91.7%, 96.3%, 84.6% and 92.5% respectively. MRS was performed in 40 cases, and the Cho/Cr, Cho/NAA and NAA/Cr mean ratios were calculated. These ratios were compared between the different categories. Statistically significant differences were found in the Cho/Cr, Cho/NAA ratios between both groups (p values<0.001**), while no statistically significant difference was found in the NAA/Cr ratio. Conclusion. Diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) are useful as additional diagnostic modalities for differentiating brain abscesses from cystic or necrotic brain tumors. Furthermore, the following MR techniques may be helpful for discriminating brain abscess from cystic or necrotic tumors: diffusion tensor imaging (DTI), perfusion weighted imaging as well as positron emission tomography computed tomography (PET-CT). This will help to improve the accuracy of MR in differentiating brain abscess from cystic or necrotic tumors.

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Diagnostic Value of Diffusion-weighted Magnetic Resonance (MR) Imaging, MR Perfusion, and MR Spectroscopy in Addition to Conventional MR Imaging in Intracranial Space-occupying Lesions

Cited by 3 publications

References 20 publications

Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions

Accuracy of Magnetic Resonance Spectroscopy in Discrimination of Neoplastic and Non-Neoplastic Brain Lesions

How SARS-CoV-2 is forcing us to reconsider and reorganize our daily neurosurgical practice

Role of MRI modalities in assessment of cystic brain Lesions: a prospective study

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