Diagnostic value of CD103 expression in bronchoalveolar lymphocytes in sarcoidosis

Mota, Patrícia Caetano; Morais, António; Palmares, Carmo; Beltrão, Marília; Melo, Natália; Santos, Ana Cristina; Delgado, Luís

doi:10.1016/j.rmed.2012.03.020

Cited by 27 publications

(30 citation statements)

References 29 publications

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“…Four studies analyzing the CD103+CD4+/CD4+ ratio in sarcoidosis, either alone or in combination with the CD4+/CD8+ ratio, have been previously performed [15,16,17,18]. The cut-off values defined in those studies to discriminate between sarcoidosis and other diagnoses were applied to our study population for comparison (table 5).…”

Section: Resultsmentioning

confidence: 99%

“…Kolopp-Sarda et al [15] found that a high CD4+/CD8+ ratio combined with a low CD103+CD4+/CD4+ ratio allowed to distinguish sarcoidosis from other ILDs with a 96% sensitivity. Similarly, Mota et al [17] found a 98% sensitivity. However, two other studies showed a lower performance of the CD103+CD4+/CD4+ ratio as a diagnostic marker for sarcoidosis [16,18].…”

Section: Introductionmentioning

confidence: 81%

“…Four previous studies have investigated the CD103 integrin on CD4+ T lymphocytes in BALF as a putative marker for sarcoidosis [15,16,17,18], and several of them have suggested that a high CD4+/CD8+ ratio combined with a low CD103+CD4+/CD4+ ratio would allow to distinguish sarcoidosis from other causes of alveolar lymphocytosis. Kolopp-Sarda et al [15] first reported that the combination of a CD4+/CD8+ ratio >2.5 and a CD103+CD4+/CD4+ ratio <0.31 had a sensitivity of 96% to discriminate between sarcoidosis and other causes of lymphocytic alveolitis.…”

Section: Discussionmentioning

confidence: 99%

“…As the peripheral blood CD4+ lymphocytes do not express CD103, differential expression of this marker on BALF CD4+ lymphocytes could serve as a diagnostic marker of sarcoidosis as compared to other ILDs. Several retrospective studies have explored this issue [13,15,16,17,18]. Kolopp-Sarda et al [15] found that a high CD4+/CD8+ ratio combined with a low CD103+CD4+/CD4+ ratio allowed to distinguish sarcoidosis from other ILDs with a 96% sensitivity.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis

Bretagne

Diatta²,

Faouzi³

et al. 2016

Respiration

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Background: The CD103 integrin is present on CD4+ lymphocytes of the bronchial mucosa, but not on peripheral blood CD4+ lymphocytes. It has been hypothesized that CD4+ lymphocytes in pulmonary sarcoidosis originate from redistribution from the peripheral blood to the lung, and therefore do not bear the CD103 integrin. Some data suggest that a low CD103+ percentage among bronchoalveolar lavage fluid (BALF) CD4+ lymphocytes discriminates between sarcoidosis and other diagnoses. Objective: To determine the diagnostic value of BALF CD103+ to identify sarcoidosis among other causes of alveolar lymphocytosis in a large retrospective case series. Methods: Among 391 consecutive bronchoalveolar lavages performed at our institution and analyzed by flow cytometry, we identified 207 cases, which were grouped into nine diagnostic categories: sarcoidosis, tuberculosis, non-tuberculous infections, hypersensitivity pneumonitis, non-specific interstitial pneumonia, organizing pneumonia, drug-induced lung diseases, other interstitial lung diseases (ILDs), and other diagnoses. To assess the discriminative value of the CD103+CD4+/CD4+ ratio to distinguish sarcoidosis from other entities, areas under ROC curves (AUC) were calculated. Results: Sarcoidosis patients (n = 53) had significantly lower CD103+CD4+/CD4+ ratios than patients in other diagnostic categories. The AUC was 62% for sarcoidosis compared to all other diagnoses, and 69% for sarcoidosis compared to other ILDs. When combining CD103+CD4+/CD4+ and CD4+/CD8+ ratios, the AUC increased to 76 and 78%, respectively. When applying previously published cut-offs to our population, the AUC varied between 54 and 73%. Conclusions: The CD103+CD4+/CD4+ ratio does not accurately discriminate between sarcoidosis and other causes of lymphocytic alveolitis, neither alone nor in combination with the CD4+/CD8+ ratio, and is not a powerful marker for the diagnosis of sarcoidosis.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis

Bretagne

Diatta²,

Faouzi³

et al. 2016

Respiration

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“…Sarcoidosis is neither a malignant nor an autoimmune disease, however, both genetic and environmental factors seem to play a role, and reaction to an unidentified antigen is suspected, despite the cellular immune response occurs in the absence of a clearly defined immunological target [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis with combined kidney damage - kidney stones, granulomatous interstitial nephritis and acute kidney injury

Zakharova¹,

Stolyarevich²

2016

Clin Case Rep Rev

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Integrin α E β 7 (CD103) expression in bronchoalveolar lymphocytes of patients with hypersensitivity pneumonitis

Couto

Palmares

Beltrão

et al. 2014

Int Arch Occup Environ Health

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Diagnostic value of CD103 expression in bronchoalveolar lymphocytes in sarcoidosis

Abstract: Assessment of CD103 expression in BALF CD4(+) T-lymphocytes may be a reliable tool for sarcoidosis diagnosis, independently of CD4(+)/CD8(+) ratio, pointing out the relevance of evaluating the CD103(+)CD4(+)/CD4(+) ratio in the ILD diagnostic work-up.

Cited by 27 publications

References 29 publications

Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis

Diagnostic Value of the CD103+CD4+/CD4+ Ratio to Differentiate Sarcoidosis from Other Causes of Lymphocytic Alveolitis

Sarcoidosis with combined kidney damage - kidney stones, granulomatous interstitial nephritis and acute kidney injury

Integrin α E β 7 (CD103) expression in bronchoalveolar lymphocytes of patients with hypersensitivity pneumonitis

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