Diagnostic value of CD10 and Bcl2 expression in distinguishing cutaneous basal cell carcinoma from squamous cell carcinoma and seborrheic keratosis

Gaballah, Mohammad A.; Ahmed, Rehab-Allah

doi:10.1016/j.prp.2015.09.009

Cited by 15 publications

(23 citation statements)

References 27 publications

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“…9 Seborrheic keratosis is a benign, hyperplastic pigmentation of the epidermis and represents the most common cutaneous neoplasm. 10 Seborrheic keratosis is one of the most common dermatologic lesions. Despite the high prevalence of SK, its aetiology and pathogenesis are poorly understood.…”

Section: Discussionmentioning

confidence: 99%

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Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross‐sectional study

Peng

Xue

Hwang

et al. 2016

Acad Dermatol Venereol

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BackgroundSkin ageing especially senile lentigo directly affects self‐esteem. For decades, senile lentigo has been associated with chronic exposure to solar radiation. However, a study conducted recently in Caucasian subjects suggested that exposure to air pollution was significantly correlated with extrinsic skin ageing, in particular senile lentigines.ObjectiveTo investigate the association between fine particulate matter (PM 2.5) and skin ageing, particularly senile lentigo and seborrheic keratosis.MethodsThe study enrolled 400 Chinese women aged 40–90 years including 210 from the Yanqing county in Beijing (low PM 2.5 exposure group) and 190 from the Xuanwumen in Beijing (high PM 2.5 exposure group). Skin ageing symptoms, particularly senile lentigines and seborrheic keratoses, were clinically assessed using scores of intrinsic and extrinsic skin ageing. An ordinal logistic regression model was used to analyse the effect of PM 2.5 on skin ageing adjusted for factors underlying skin ageing.ResultsIn the study population of Xuanwumen, we found that senile lentigo on cheeks and back of hands was 1.48 times and 2.8 times higher, respectively, compared with those from Yanqing county. However, no association was found between PM 2.5 and seborrheic keratosis. We found that other variables such as smoking, second‐hand smoking, contact with fossil fuels and skin types were significantly associated with skin ageing.ConclusionThese results indicate that PM 2.5 was another extrinsic factor promoting skin ageing.

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Section: Discussionmentioning

confidence: 99%

“…11 Though SKs appear more frequently on areas exposed to sun, lesions may also occur on any site of the skin except palms or soles, which are not sunexposed. 2,9,10 Viral infection is also considered a possible cause of SKs based on clinical similarities to warts. 2 The evidence indicates that SK is probably caused by intrinsic factors.…”

Section: Discussionmentioning

confidence: 99%

Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross‐sectional study

Peng

Xue

Hwang

et al. 2016

Acad Dermatol Venereol

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“…These studies showed that contrary to suprabasal Bcl-2 negative keratinocytes causing SCC, SK was shown to be due to Bcl-2 positive basal keratinocytes. This situation explains the different staining patterns (8,(36)(37)(38). In our study staining was observed to be greater in SK with more basaloid proliferation.…”

Section: Discussionmentioning

confidence: 41%

Assessment of BCL-2 expression in actinic keratosis, keratoacanthoma and seborrheic keratosis cases

Önder¹,

Erdem²,

Haktanır³

et al. 2019

Ann Med Res

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Aim: One of the main functions of apoptosis is the elimination of cells with damaged DNA, including premalignant cells in skin. Apoptosis is regulated by the balance between antiapoptotic and proapoptotic proteins. The bcl-2 protein has been shown antiapoptotic effect. It protects cell against apoptosis induced by different death-inducing signals. Material and Methods: In this study the authors have analyzed imunohistochemically the expression of bcl-2 protein in the histopathological variants of the precancerous lesion [actinic keratosis (AK) (28 cases) and keratoacanthomas (KA) (12 cases) and seborrheic keratosis (SK) (22 cases) in skin. Results: In cases of AK, bcl-2 expression was confined to basal cell layer, as well as in two cases of thorough epidermis. SK expression of bcl-2 protein was in areas of basaloid proliferation.KA expression of bcl-2 protein was not dome-shaped keratin-filled crater areas but bcl-2 expression was confined of non crater areas. Conclusion: In conclusion, bcl-2 expression supports the observation that tumor cells are derived from basal keratinocytes in AK and SK and not support the observation that tumor cells are derived from basal keratinocytes in KA.

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“…B‐cell lymphoma 2 (BCL‐2) has previously been reported to be positive in both the keratinocytes and dendritic cells of seborrheic keratosis (SK), but not typically seen in squamous cell carcinoma (SCC) . Several studies have shown insulin‐like growth factor II mRNA‐binding protein 3 (IMP3), is overexpressed in a variety of malignant neoplasms including SCC, but not in benign tissues .…”

Section: Introductionmentioning

confidence: 99%

“…Additional studies assessing the utility of CD10, 5‐hydroxymethylcytosine (5‐hmC), and GATA binding protein 3 (GATA3) immunohistochemistry have recently been described. CD10, also called common acute lymphoblastic leukemia antigen (CALLA), has been depicted to be helpful in distinguishing SK from SCC . The loss of 5‐hmC expression has been significantly associated with cancers such as SCC .…”

Section: Introductionmentioning

confidence: 99%

Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL‐2 and IMP3 immunohistochemistry

et al. 2018

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Diagnostic value of CD10 and Bcl2 expression in distinguishing cutaneous basal cell carcinoma from squamous cell carcinoma and seborrheic keratosis

Cited by 15 publications

References 27 publications

Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross‐sectional study

Exposure to fine particulate matter associated with senile lentigo in Chinese women: a cross‐sectional study

Assessment of BCL-2 expression in actinic keratosis, keratoacanthoma and seborrheic keratosis cases

Distinguishing between irritated seborrheic keratosis and squamous cell carcinoma in situ using BCL‐2 and IMP3 immunohistochemistry

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