Diagnostic Value of C-Reactive Protein Levels in Postoperative Infectious Complications After Bariatric Surgery: a Systematic Review and Meta-Analysis

Lee, Yung; McKechnie, Tyler; Doumouras, Aristithes G.; Handler, Chovav; Eskicioglu, Cagla; Gmora, Scott; Anvari, Mehran; Hong, Dennis

doi:10.1007/s11695-019-03832-5

Cited by 53 publications

(22 citation statements)

References 26 publications

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“…Earlier reported studies extensively discuss about the hsCRP biomarker [24]. Mean hsCRP level was higher in present study than those earlier reported studies, [25] it was noted from this study, that higher hsCRP level depicts the high risk of patients for the development of cardiovascular disease (CVD) [26,27].…”

Section: Discussioncontrasting

confidence: 37%

Prime Risk Factors to Act as Biomarkers for the Diagnosis of Myocardial Infarction

Verma

Kumar

Singh

et al. 2021

JPRI

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Aims: This study was done to find out retrospective case-control with respect to myocardial infarction diagnosis on the basis of biochemical markers and lipid profile characteristics. Design and Setting: This study was conducted at the Department of Biochemistry and sample collection at LPS Institute of Cardiology & Cardiac Surgery Department, Kanpur. Methods: The total number of subjects participated in this study (n=178), of either sex (with age>65years) were included in this study from the case collected from Outpatient Department (OPD) and Indoor Patient Department (IPD) and control from patients attendant, which consisted of two subject groups: The group I: myocardial infarction (cases) n= 89 and Group II: Healthy Subjects (controls) n= 89. Laboratory methodology was performed to determine the prime important risk factors such as body mass index (BMI), blood pressure and lipid profile characteristics associated with myocardial infarction. Risk factors were analyzed by Chi-square and Pearson correlation, receiver operating characteristic (ROC) curve method considered significant when the critical, P <0.01level was set up, for a 95% confidence interval. Results: Total number of (n=178) participants (males=65; mean age of 65 years, females=24, mean age of 58 years) at 95% CI were considered in this study, out of these, 89 individuals were expected to have risk of myocardial infarction (especially observed in case groups), and remaining 89 individuals were considered as control groups, all were included as, study subjects. Conclusion: The current study concludes the importance of myocardial infarction in presence of prognostic inflammatory markers: higher IL-6 and plasma fibrinogen level, instead of high-sensitivity C-reactive protein, incase and control groups.

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Section: Discussioncontrasting

confidence: 37%

Prime Risk Factors to Act as Biomarkers for the Diagnosis of Myocardial Infarction

Verma

Kumar

Singh

et al. 2021

JPRI

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“…C-reactive protein (CRP), interleukin 1 beta (IL-1β), interferon alpha-2 (IFN-α2), interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein 1 (MCP-1), IL-6, IL-8, IL-10, IL-12p70, IL-17A, IL-18, IL-23 and IL-33 were measured. Briefly, serum-CRP was analyzed according to standard procedures and levels >3.0 (mg/dL) were considered as moderate to severe inflammation [ 31 ]. The immunoassay Human Inflammation Panel 1 LEGENDplexTM, Multi-Analyte Flow Assay Kit from BioLegend (San Diego, CA, USA) was used to measure serum-cytokine concentrations with the following reference range in healthy subjects according to the manufacturer’s kit manual: IL-1β, not detectable (ND)–20.4 pg/mL; IFN-α2, ND–155.8 pg/mL; IFN-γ, ND–15.0 pg/mL; TNF-α, ND–27.0 pg/mL; MCP-1, 72.7–431.5 pg/mL; IL-6, ND–13.1 pg/mL; IL-8, 3.4–77.1 pg/mL; IL-10, ND–9.9 pg/mL; IL-12p70, ND–4.7 pg/mL; IL-18, 53.7–276.9 pg/mL; IL-23, ND–94.2 pg/mL and IL-33, ND-192.2 pg/mL.…”

Section: Methodsmentioning

confidence: 99%

Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients

et al. 2021

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There are few data on the longitudinal association of cytokine and appetite among older hospitalized patients. We aimed to investigate the impact of the changes of inflammatory cytokines on appetite in older hospitalized patients. A total of 191 patients (mean age 81.3 ± 6.6 years, 64% women) participated in this prospective longitudinal observational study. Appetite was evaluated using the Edmonton Symptom Assessment System on admission and after seven days. Serum cytokines such as IL-1β, IL-6, IL-8, IL-10, IL-12p70, IL-17, IL-18, IL-23 and IL-33, IFN-α2, IFN-γ, TNF-α and MCP-1 were measured both times. No significant differences in the mean serum levels of all the cytokines could be detected overtime in relation to appetite changes, except for IL-18. Appetite significantly deteriorated overtime in patients with increasing IL-18 levels and improved in those without significant changes in IL-18 levels. In a stepwise regression analysis, changes of IL-18 levels were the major independent predictor for the changes of patients’ appetite and explained 4% of the variance, whereas other cytokines and variables, such as age, sex, infection and disease, did not show any impact on appetite changes. We conclude that IL-18 seems to exert a significant impact on appetite in acutely ill older hospitalized patients and should, therefore, be considered as a potential target in the diagnosis, prevention and treatment of malnutrition.

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“…Levels between 0.0–0.5 (mg/dL) and between 0.5–3.0 (mg/dL) are considered as no and mild inflammation, respectively. A level >3.0 (mg/dL) is considered as moderate to severe inflammation [28].…”

Section: Methodsmentioning

confidence: 99%

Inflammation, Appetite and Food Intake in Older Hospitalized Patients

et al. 2019

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The effect of inflammation on appetite and food intake has been rarely studied in humans. In this study, we examined the association of C-reactive protein (CRP), as an inflammatory marker, with appetite and food intake among older hospitalized patients. A total of 200 older individuals, who were consecutively admitted to a geriatric acute care ward, participated in this prospective observational study. Appetite was evaluated using the Edmonton Symptom Assessment System (ESAS) and the Simplified Nutritional Appetite Questionnaire (SNAQ), respectively. Food intake was measured according to plate diagram method and participants were categorized as having food intake <75% and ≥75% of meals served. Nutritional status was evaluated using the Mini Nutritional Assessment Short Form (MNA-SF). In addition, serum CRP was analyzed and the levels >3.0 (mg/dL) were considered as moderate to severe inflammation. Of total population with mean age 81.4 ± 6.6 years (62.5% females), 51 (25.5%) had no inflammation and 88 (44.0%) and 61 (30.5%) had mild and moderate to severe inflammation, respectively. According to MNA-SF, 9.0% and 60.0% had normal nutritional status or a risk of malnutrition, respectively, whereas 31.0% were malnourished. Based on the SNAQ-appetite-question, 32.5% of the patients demonstrated poor and very poor appetite whereas 23.5% reported severe loss of appetite according to ESAS. Ninety-five (48.0%) of the participants had food intake <75% of the meals offered. Significant associations between SNAQ-appetite (p = 0.003) and ESAS-appetite (p = 0.013) scores and CRP levels were observed. In addition, significant differences were observed in CRP levels between intake ≥75% and <75% of meals served (p < 0.001). Furthermore, there were significant associations between appetite and nutritional status whereas malnourished older patients demonstrated a decreased appetite compared to those with normal nutritional status (p = 0.011). In a regression analysis, inflammation was the major independent risk factor for patients’ appetite (p = 0.003) and food intake (p = 0.011) whereas other variables such as infection (p = 0.960), chronic inflammatory diseases (p = 0.371), age (p = 0.679) and gender (p = 0.447) do not show any impact on appetite. Our findings confirm that poor appetite and low food intake are associated with inflammation in older hospitalized patients, suggesting that inflammation may contribute an important aspect to the development of malnutrition in these patients.

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Diagnostic Value of C-Reactive Protein Levels in Postoperative Infectious Complications After Bariatric Surgery: a Systematic Review and Meta-Analysis

Cited by 53 publications

References 26 publications

Prime Risk Factors to Act as Biomarkers for the Diagnosis of Myocardial Infarction

Prime Risk Factors to Act as Biomarkers for the Diagnosis of Myocardial Infarction

Longitudinal Changes of Cytokines and Appetite in Older Hospitalized Patients

Inflammation, Appetite and Food Intake in Older Hospitalized Patients

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