Diagnostic value of brain natriuretic peptide and β-endorphin plasma concentration changes in patients with acute left heart failure and atrial fibrillation

Feng, Shao-Dan; Jiang, Yong; Lin, Zhihong; Lin, Peihong; Lin, Si-Ming; Liu, Qicai

doi:10.1097/md.0000000000007526

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…BNP mean concentration ± SD showed a statistically significant association with heart failure grades and increased with increasing in grades getting its peak value in patients with grade IV heart failure (1182.697±284.931) with a P-value of 0.0001. There is another preceding study demonstrated that the BNP concentration elevated with the advancement of heart failure grade [27].Further studies also found same results as other studies also found similar results, showing that increase of homocysteine levels associated with increase NT-pro-BNP levels through a link with impaired mitochondrial fatty oxidation, in two contrasted populations [28,29].Other previous study show compatible results with this study, which reported that higher level of BNP in patients with class 4 and the mean level was (8270.2±6116.9) with a P=value of < 0.05 [26].…”

Section: Discussionsupporting

confidence: 77%

Homocysteinemia in Heart Failure

Khaleefah¹,

Latif²,

Jaffar³

2021

DJM

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Background: Heart failure represents a major health problem leading to considerable mortality morbidity. High total homocysteine concentrations have been related to increased risk of atherosclerosis and its sequel, including coronary heart disease, cardiovascular mortality, and stroke. Brain Natriuretic peptide is a member of a group of peptide hormones similar in structure, used as a specific marker for diagnosing heart failure. This marker increases gradually with the progression of the grade of heart failure. Objective: The current study aims to measure and investigate the difference in the level of homocysteine between patients with heart failure and without, to find the relationship between the level of homocysteine and grade of heart failure, and to find out the correlation between homocysteine levels with Brain Natriuretic peptide levels. Patients and Methods: This case-control study involved 200 participants, 100 patients with a history of chronic heart failure, and 100 control participants.A self-constructed questionnaire form prepared to collect selected variables, the participant’s weight, height, temperature, electrocardiography measured by trained staff, Brain Natriuretic peptide used as a specific marker for diagnosing heart failure. Blood samples were taken early in the morning from the patient and control groups, after at least 12-hours of fasting and a 20-minute rest. Analysis of all samples of blood was performed in the Biochemistry Laboratory of Baqubah teaching hospital to measure the levels of homocysteine by Human Homocysteine ELISA kit. Results: The sample was selected homogenously in terms of age and gender. Overweight, obesity, current and ex-smoker, history of hypertension, and history of diabetes mellitus were significantly higher in patients with heart failure than control. The fasting mean homocysteine level was significantly higher in patients (20.049nmol/ml) than in control (2.734nmol/ml). The fasting mean homocysteine level was significantly elevated in the patients with a positive history of hypertension and diabetes mellitus (p-value ≤0.05) than patients with a negative history. The level of homocysteine was correlated significantly and positively with the level of Brain Natriuretic peptide(r=0.39, p=0.001). The fasting mean homocysteine level was significantly increased with an increase in the severity (grades) of the heart failure (p-value = 0.001). Conclusion: There was a relationship between the homocysteine level with the development, and severity (grades) of the heart failure as well as significantly and positively correlated with the Brain Natriuretic peptide level. Keywords: Heart Failure; Homocysteinemia; Brain Natriuretic peptide

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Section: Discussionsupporting

confidence: 77%

Homocysteinemia in Heart Failure

Khaleefah¹,

Latif²,

Jaffar³

2021

DJM

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“…However, even if BNP is specific and sensitive for detecting early acute cardiac failure, despite the increase, the APN‐D levels remained within a normal rang and did not reach clinically significant levels (Feng et al. ), suggesting the presence of adaptation mechanisms in spearfishermen due to their high‐level of training.…”

Section: Discussionmentioning

confidence: 99%

Physiological stress markers during breath‐hold diving and SCUBA diving

et al. 2019

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This study investigated the sources of physiological stress in diving by comparing SCUBA dives (stressors: hydrostatic pressure, cold, and hyperoxia), apneic dives (hydrostatic pressure, cold, physical activity, hypoxia), and dry static apnea (hypoxia only). We hypothesized that despite the hypoxia induces by a long static apnea, it would be less stressful than SCUBA dive or apneic dives since the latter combined high pressure, physical activity, and cold exposure. Blood samples were collected from 12 SCUBA and 12 apnea divers before and after dives. On a different occasion, samples were collected from the apneic group before and after a maximal static dry apnea. We measured changes in levels of the stress hormones cortisol and copeptin in each situation. To identify localized effects of the stress, we measured levels of the cardiac injury markers troponin ( cTnI ) and brain natriuretic peptide ( BNP ), the muscular stress markers myoglobin and lactate), and the hypoxemia marker ischemia‐modified albumin ( IMA ). Copeptin, cortisol, and IMA levels increased for the apneic dive and the static dry apnea, whereas they decreased for the SCUBA dive. Troponin, BNP , and myoglobin levels increased for the apneic dive, but were unchanged for the SCUBA dive and the static dry apnea. We conclude that hypoxia induced by apnea is the dominant trigger for the release of stress hormones and cardiac injury markers, whereas cold or and hyperbaric exposures play a minor role. These results indicate that subjects should be screened carefully for pre‐existing cardiac diseases before undertaking significant apneic maneuvers.

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“…In many pathological conditions, such as the ventricular volumetric load and pressure overload, BNP concentration will be increased in the blood ( Kou et al, 2016 ). The higher severity of heart failure will result in higher concentration of BNP ( Hahn et al, 2016 ; Feng et al, 2017 ). BNP shows good specificity in differential diagnosis of CHF ( Jin et al, 2018 ), cardiogenic dyspnea ( Golshani et al, 2016 ), and lung-derived respiratory distress ( Sun et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Black Garlic Improves Heart Function in Patients With Coronary Heart Disease by Improving Circulating Antioxidant Levels

et al. 2018

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Background: Black garlic (BG) has many health-promoting properties.Objectives: We aimed to explore the clinical effects of BG on chronic heart failure (CHF) in patients with coronary heart disease (CHD).Design: The main components of BG were measured by gas chromatography–mass spectrometry (GC–MS) and its antioxidant properties were determined by the clearance rate of free radicals. One hundred twenty CHF patients caused by CHD were randomly and evenly assigned into BG group and placebo group (CG). The duration of treatment was 6 months. Cardiac function was measured according to the New York Heart Association (NYHA) functional classification system. The following parameters were measured, including walking distance, BNP precursor N-terminal (Nt-proBNP), left-ventricular ejection fraction (LVEF) value, and the scores of quality of life (QOL). The circulating antioxidant levels were compared between two groups.Results: There are 27 main compounds in BG with strong antioxidant properties. BG treatment improved cardiac function when compared with controls (P < 0.05). The QOL scores and LVEF values were higher in the BG group than in the CG group while the concentration of Nt-proBNP was lower in the BG group than in the CG group (P < 0.05). Circulating antioxidant levels were higher in the BG group than in the CG group. Antioxidant levels had positive relation with QOL and LVEF values, and negative relation with Nt-proBNP values.Conclusion: BG improves the QOL, Nt-proBNP, and LVEF in CHF patient with CHD by increasing antioxidant levels.

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Diagnostic value of brain natriuretic peptide and β-endorphin plasma concentration changes in patients with acute left heart failure and atrial fibrillation

Cited by 10 publications

References 18 publications

Homocysteinemia in Heart Failure

Homocysteinemia in Heart Failure

Physiological stress markers during breath‐hold diving and SCUBA diving

Black Garlic Improves Heart Function in Patients With Coronary Heart Disease by Improving Circulating Antioxidant Levels

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