Diagnostic Value of Biochemical Analysis of Pleural Effusions: Carcinoembryonic Antigen and Beta2Microglobulin

Vladutiu, Adrian O.; Adler, Richard H.; Brason, F. Wells

doi:10.1093/ajcp/71.2.210

Cited by 30 publications

(7 citation statements)

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“…Elevated serum 02m levels in patients with a variety of benign and malignant diseases were described by several groups of investigators (11,12,17,19,20). However, elevated 02m was not found in all cancer patients.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Release of β2-Microglobulin by Human Tumors Grown in Nude Mice

DiPersio¹,

Dingle²,

Michael³

et al. 1980

Pathobiology

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Human tumors implanted subcutaneously into athmic mice produced human β₂-microglobulin which was readily identified and quantified in mouse plasma. Implanted solid tumors of the lines Clouser, SW480, HEp-2, Capan-1, and HT-29 released amounts of β₂-microglobulin directly related to tumor mass. The extractable β₂-microglobulin per gram of tumor was constant for each cell line, but there was a 100-fold variation between the lines. In general, the plasma level of β₂-microglobulin correlated with the amount of free β₂-microglobulin extracted from each tumor. From these observations it can be concluded that the variability observed in the circulating levels of β₂-microglobulin among cancer patients is related to the β₂-microglobulin content of the tumor and the total tumor mass.

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Section: Discussionmentioning

confidence: 98%

“…Elevation in serum occurs in a number of states includ ing renal disease, hepatobiliary disorders, and pregnancy. Several investigators have shown 02m to be elevated in cancer patients (11,12,17,19) to varying degrees. The reasons for this variability are not known.…”

Section: Introductionmentioning

confidence: 99%

Release of β2-Microglobulin by Human Tumors Grown in Nude Mice

DiPersio¹,

Dingle²,

Michael³

et al. 1980

Pathobiology

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“…The cut-off carcinoembryonic antigen level used to separate benign from malignant effusions varies widely according to different series, ranging from 2.5 to 20 μg/l (2,(13)(14)(15)(16). Between 34 and 38% of malignant fluids have been reported with a carcinoembryonic antigen level above the author's selected cut-off point.…”

Section: Discussionmentioning

confidence: 99%

Short Communication

1996

CCLM

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In order to discriminate between malignant and benign effusions, the values of tissue polypeptide specific antigen, carcinoembryonic antigen and squamous cell carcinoma associated antigen were measured in the pleural fluid of 30 patients with neoplasm, 10 with tuberculous pleurisy, 10 with transudates due to congestive heart failure or cirrhosis, 29 with parapneumonic effusions and 23 with benign diseases other than tuberculosis and pneumonia. Carcinoembryonic antigen and tissue polypeptide specific antigen levels in effusions due to neoplasms were significantly higher than those in effusions due to other diseases. The areas under Receiver Operating Characteristic curves for carcinoembryonic antigen and tissue polypeptide specific antigen determinations were 0.69 and 0.67, respectively. No significant differences were found in the pleural fluid squamous cell carcinoma associated antigen levels between neoplasms and other diseases.The ability of tissue polypeptide specific antigen and carcinoembryonic antigen to discriminate between benign and malignant effusions may be considered comparable. Although both carcinoembryonic antigen and tissue polypeptide specific antigen showed a low accuracy (the number of undiagnosed pleural effusions is considerably high), both tissue polypeptide specific antigen and carcinoembryonic antigen determinations may contribute to a correct diagnostic classification. Moreover, the combination of these markers provides a specificity of 97.2%. However, the low number of positivities obtained for tissue polypeptide specific antigen and carcinoembryonic antigen together (13 cases in our series) reveals the need for further investigations.

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“…Several studies [14,15,17,18] have also demonstrated that measurements of CEA are of diagnostic value in malignant pleural effusions. By contrast, reactivity against CEA is negative or only weakly positive in mesothelioma [11-13, 19, 20].…”

Section: Discussionmentioning

confidence: 99%

Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

Shijubo¹,

Honda²,

Fujishima³

et al. 1995

Eur Respir J

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Lung surfactant protein-A (SP-A) is a major phospholipid-associated glycoprotein in surfactant, and is a useful immunohistochemical marker for lung adenocarcinoma. Carcinoembryonic antigen (CEA) has not been immunohistochemically detected in mesothelioma. In pleural effusions due to malignant mesothelioma, very low concentrations of SP-A and CEA can be expected. We studied the value of combined determinations of CEA and SP-A in pleural fluid to distinguish between lung adenocarcinoma and mesothelioma. SP-A and CEA concentrations were measured in pleural effusions from 78 patients with lung adenocarcinoma and 10 with malignant mesothelioma. SP-A concentrations in pleural effusions due to lung adenocarcinoma and mesothelioma were 516 +/- 140 and 16.9 +/- 3.6 ng.ml-1 (mean +/- SEM), respectively. CEA concentrations in pleural effusions due to lung adenocarcinoma and mesothelioma were 239 +/- 92.4 and 1.7 +/- 0.3 ng.ml-1, respectively. SP-A values did not exceed 100 ng.ml-1 in any of 10 mesotheliomas, whilst in 37 of 78 lung adenocarcinomas they did. CEA values did not exceed 10 ng.ml-1 in any of 10 mesotheliomas, whilst in 53 of 78 lung adenocarcinomas they did. Increased values of SP-A and/or CEA were found in pleural effusions from 67 of 78 lung adenocarcinomas. It is concluded that a combination of CEA and SP-A assays in pleural effusions will be helpful for discriminating lung adenocarcinoma from mesothelioma.

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Diagnostic Value of Biochemical Analysis of Pleural Effusions: Carcinoembryonic Antigen and Beta₂Microglobulin

Cited by 30 publications

References 0 publications

Release of <i>β</i><sub>2</sub>-Microglobulin by Human Tumors Grown in Nude Mice

Release of <i>β</i><sub>2</sub>-Microglobulin by Human Tumors Grown in Nude Mice

Short Communication

Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma

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