Diagnostic value of apparent diffusion coefficient to differentiate benign from malignant vertebral bone marrow lesions

Fawzy, Faten; Tantawy, Hazim I.; Ragheb, Ahmad S.; Hashem, Safwat Abo

doi:10.1016/j.ejrnm.2013.01.010

Cited by 12 publications

(3 citation statements)

References 11 publications

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“…15,33 The mean/median ADC value in infectious spondylitis ranged between 0.79 and 1.16 3 10 23 mm 2 s 21 in previous reports. 9,37,38 It was 1.80 6 0.12 3 10 23 mm 2 s 21 in our patients with degeneration, significantly higher than that in the other group with infection (1.31 6 0.12 3 10 23 mm 2 s 21 ; p , 0.001).…”

Section: Discussioncontrasting

confidence: 49%

Diffusion-weighted magnetic resonance imaging in differentiating acute infectious spondylitis from degenerative Modic type 1 change; the role ofb-value, apparent diffusion coefficient, claw sign and amorphous increased signal

Daghighi¹,

Poureisa²,

Safarpour³

et al. 2016

BJR

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Section: Discussioncontrasting

confidence: 49%

Diffusion-weighted magnetic resonance imaging in differentiating acute infectious spondylitis from degenerative Modic type 1 change; the role ofb-value, apparent diffusion coefficient, claw sign and amorphous increased signal

Daghighi¹,

Poureisa²,

Safarpour³

et al. 2016

BJR

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“…Both Pui et al (25) agree with Fawzy et al, (21) who found that DWI and ADC values have high sensitivity and specificity in differentiating benign from malignant causes of vertebral collapse 100% and 93%, respectively, but low sensitivity and specificity in differentiating infection from malignancy 63% and 63%, respectively. This going in hand with our results as we found that DWI and ADC values have high sensitivity and specificity in differentiating benign from malignant causes of vertebral collapse 100% and 90.3%, respectively, while PPV and NPV were 75 % and 100 % respectively, but low sensitivity and specificity in differentiating infection from malignancy 63% and 63%, respectively.…”

Section: Role Of Diffusion -Weighted Magnetic Resonance Imaging In ………supporting

confidence: 74%

Role of Diffusion – Weighted Magnetic Resonance Imaging in Characterization of Vertebral Bone Marrow Pathological Lesions

Lakouz¹,

Radwan²,

Sarhan³

et al. 2013

Zagazig University Medical Journal

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AIM:To evaluate the role of diffusion weighted magnetic resonance imaging in characterization of vertebral bone marrow pathological lesions. MATERIALS AND METHODS: Forty patients with bone marrow abnormal MRI signal intensity were enrolled in the study and upon MRI finding they wear grouped into four groups. DWI was performed with b values of 0and 500 s/ mm 2 . Results of the histo-pathological evaluation or MRI follow up or isotope were compared with the DWI results. Apparent diffusion coefficient (ADC) values were calculated. RESULTS: All cases of malignant collapse (4 cases 10%) were hyper intense on DWIs and hypo intense on ADC map with mean ADC (0.8 ± 0.33 x 10−3 mm2/s). All benign osteoporotic collapse cases (7 cases 17.5%) were hypo intense (3 cases) or iso to hypo intense (4 cases) on DWIs and all wear hyper intense on ADC with mean ADC (1.64 ± 0.33 x 10−3 mm2/s). Twelve cases with endplate changes, the eight infectious spondylitis recorded mean ADC value (1.03 ±0.33× 10−3mm2/s). The remaining, 4 cases (10 %) with degenerative Modic I end plate changes recorded ADC value (1.76 ±0.33× 10−3mm2/s). Also (3 cases) malignant bone marrow infiltration without collapse were hyperintense on DWIs and hypointense on ADC map with mean ADC (0.8 ± 0.33 x 10−3 mm2/s). The mean ADC in hemangioma was (1.9 ± 0.33 x 10−3 mm2/s) and in ABC (1.93 ± 0.33 x 10−3 mm2/s). DW study of 4 cases respond to therapy recorded mean ADC value (1.64 ±0.33× 10−3mm2/s), however, the 2 cases with residual viable tumor tissue record (0.79 ±0.33× 10−3mm2/s). DWI and ADC values have high sensitivity and specificity in differentiating benign from malignant lesions and in post therapy follow up. CONCLUSIONS: DWI with quantitative ADC measurements Using b value (b=500 s / mm 2 ) can be useful in differentiating benign from malignant bone marrow lesions, differentiated between causes of end plate changes and be used in post therapy follow up.

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“…Abo Dewan et al (2015), [15] Fawzy et al (2013). [26] Qualitative and Castillo et al (2000) [23] who found qualitative assessment useful in differentiating malignant from benign cause.…”

Section: Qualitative Assessmentmentioning

confidence: 99%

Mri in Non-Traumatic Vertebral Collapse With Emphasis on in-Phase/Opposed-Phase and Diffusion-Weighted Imaging Sequences With Histopathological Correlation

Bhuyan¹,

Kempegowda²

2016

jemds

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Diagnostic value of apparent diffusion coefficient to differentiate benign from malignant vertebral bone marrow lesions

Cited by 12 publications

References 11 publications

Diffusion-weighted magnetic resonance imaging in differentiating acute infectious spondylitis from degenerative Modic type 1 change; the role ofb-value, apparent diffusion coefficient, claw sign and amorphous increased signal

Diffusion-weighted magnetic resonance imaging in differentiating acute infectious spondylitis from degenerative Modic type 1 change; the role ofb-value, apparent diffusion coefficient, claw sign and amorphous increased signal

Role of Diffusion – Weighted Magnetic Resonance Imaging in Characterization of Vertebral Bone Marrow Pathological Lesions

Mri in Non-Traumatic Vertebral Collapse With Emphasis on in-Phase/Opposed-Phase and Diffusion-Weighted Imaging Sequences With Histopathological Correlation

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