Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: An Italian multicentric study and review of the literature

Bartoloni, Elena; Alunno, Alessia; Bistoni, Onelia; Bizzaro, Nicola; Migliorini, Paola; Morozzi, Gabriella; Doria, Andrea; Mathieu, Alessandro; Lotzniker, Milvia; Allegri, F.; Riccieri, Valeria; Alpini, Claudia; Gabrielli, Armando; Tampoia, Marilina; Gerli, Roberto

doi:10.1016/j.autrev.2012.02.015

Cited by 50 publications

(44 citation statements)

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“…When sensitivity and specificity were considered simultaneously, the Q * index for anti-MCV was 0.817, whereas that for anti-CCP was 0.885. These results are consistent with those of a previous relevant systematic review showing less specificity of anti-MCV than anti-CCP in the diagnosis of RA [12] and previous data reporting a better sensitivity with a lower specificity of anti-MCV in comparison with anti-CCP [42]. Our data demonstrate that anti-MCV has a lower specificity and overall diagnostic accuracy than anti-CCP in RA.…”

Section: Discussionsupporting

confidence: 93%

Diagnostic accuracy of anti-MCV and anti-CCP antibodies in rheumatoid arthritis

2015

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Section: Discussionsupporting

confidence: 93%

Diagnostic accuracy of anti-MCV and anti-CCP antibodies in rheumatoid arthritis

2015

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“…Diagnoses were known in 948 patients and the anti-CCP positivity was distributed as follows: 420/754 RA (56%), 5/58 Sjögren's syndrome (SS; 8.6%), 1/76 psoriatic arthritis (PsA; 1.3%), 0/32 systemic lupus erythematosus (SLE), 1/28 systemic sclerosis (SSc; 3.5%), with overall prevalence of 3.7% in non-RA patients. Anti-CCP prevalence in SLE, SS, SSc, and PsA was in line with that extrapolated from an Italian multicenter study comparing the diagnostic value of anti-CCP, antimutated citrullinated vimentin, and antiviral citrullinated peptide 2 8 .…”

Section: Anticyclic Citrullinated Peptide Antibodies In Patients Withsupporting

confidence: 85%

Anticyclic Citrullinated Peptide Antibodies in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: Clinical or Pathogenic Significance?

et al. 2015

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“…RA is a systemic disease and elicits not only synovitis and joint destruction but also functional disabilities and extraarticular involvement; therefore, early diagnosis of the disease is of great importance [21][22][23][24]. While RF was the only serologic marker included in the 1987 classification criteria of the American College of Rheumatology (ACR) for RA, we currently understand that many other autoantibodies such as anti-RA33, anti-Sa, anti-p68, anti-calpastatin, anti-ERM (Ezrin, radoxin and moesin) and antiperinuclear factor are also detected in RA [25,26].…”

Section: Discussionmentioning

confidence: 99%

Predictive value of anti-citrullinated peptide antibodies: a real life experience

et al. 2014

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Rheumatoid Arthritis (RA) is an autoimmune destructive joint disease, characterized by the presence of rheumatoid factor and anti-citrullinated peptide antibodies. Anti-citrullinated peptide antibodies were recently defined as RA criterion with sensitivity and specificity of 50-80 and 75-95 %, respectively. However, in the general population, the predictive value of anti-citrullinated peptide antibodies is yet to be determined. Herein, we aim to determine the predictive value of anti-citrullinated peptide antibodies in real life as well as clinical and serological factors related to this value. Retrospective cross-sectional study of consecutive samples evaluated for anti-citrullinated peptide antibodies in a referral autoimmune laboratory. Demographic and clinical parameters at the time the sample was drawn were collected. During November 2011 through December 2013, a total of 215 anti-citrullinated peptide antibody tests were performed in our laboratory. Data were available for 140 samples of which only 28 samples were positive for anti-citrullinated peptide antibodies. Of the 140 patients tested, 18 were diagnosed with RA, of which 12 were positive and 6 were negative for anti-citrullinated peptide antibody test. Thus, in this cohort, anti-citrullinated peptide antibodies were positive in 20 % of samples with a positive predictive value (PPV) of 43 % and a negative predictive value of 95 %. In real life, only 20 % of anti-citrullinated peptide antibody tests referred to a tertiary center where found to be positive. The negative predictive value of this test is very high and may support the common use of anti-citrullinated peptide antibody test as an exclusion criterion in the process of evaluating a patient with rheumatic disease.

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Diagnostic value of anti-mutated citrullinated vimentin in comparison to anti-cyclic citrullinated peptide and anti-viral citrullinated peptide 2 antibodies in rheumatoid arthritis: An Italian multicentric study and review of the literature

Cited by 50 publications

References 33 publications

Diagnostic accuracy of anti-MCV and anti-CCP antibodies in rheumatoid arthritis

Diagnostic accuracy of anti-MCV and anti-CCP antibodies in rheumatoid arthritis

Anticyclic Citrullinated Peptide Antibodies in Patients with Rheumatic Diseases other than Rheumatoid Arthritis: Clinical or Pathogenic Significance?

Predictive value of anti-citrullinated peptide antibodies: a real life experience

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