Diagnostic value of androgens determinations in “idiopathic” hirsutlsm

Caufriez, Anne; Copinschi, Georges; L’Hermite, Marc; Lejeune-Lenain, C.; Franckson, Jean

doi:10.1016/0022-4731(81)90118-7

Cited by 1 publication

(2 citation statements)

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“…The best diagnostic criterion is an increased baseline LH level or LH response to LHRH, contrasting with normal FSH plasma levels. However, as shown in table II, this criterion was absent in 20-30% of our patients with PCO or borderline ovaries, as previously re ported by other workers [24], In agreement with Caufriez et al [16], we observed that an increased LH response to LHRH exists in only 10-20% of cases presenting a normal baseline LH plasma level (this profile more over is not pathognomonic of PCO) and that the use of two consecutive LHRH stimula tions separated by a 120-min interval does not increase the diagnostic capacity of the LHRH test. Thus, laparoscopy is apparently required to achieve diagnosis in certain cases.…”

Section: Methods To Identify the Cause Of Hyperandrogenismsupporting

confidence: 79%

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Investigative Strategy of Hyperandrogenism in Women

Buvat¹,

Dewailly²,

Marcolin³

et al. 1983

Horm Res

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Investigative procedures in the assessment of female hyperandrogenism are reviewed. Based on their experience, the authors suggest an inexpensive investigative strategy in hyperandrogenic females consisting of the following: the first step depends upon the clinical symptoms – in cases of hirsutism with regular menstrual cycles, plasma testosterone (T) and plasma dehydroepiandrosterone sulfate (DHA-S) are assayed, and the basal body temperature chart is recorded. In cases of hirsutism with irregular or anovulatory menstrual cycles, in addition to T and DHA-S, plasma 17-hydroxyprogesterone and urinary-free cortisol are assayed. In case of anovulation without hirsutism, T and DHA-S are assayed, and the LHRH test is performed. The results of this first investigation allow to attribute to the woman one of the six following hormone profiles: (1) metabolic hyperadrenalism; (2) tumoral hyperandrogenism; (3) 21-hydroxylase defect; (4) nontumoral DHA-S increase; (5) nontumoral ovarian hyperandrogenism; (6) idiopathic hirsutism. The additional investigative procedures required in each of these groups are detailed.

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Section: Methods To Identify the Cause Of Hyperandrogenismsupporting

confidence: 79%

“…The association of these three assays leads to the detection of an anomaly in 80% (per sonal data from 75 cases) to 90% [16] of hir- sute women. The estimation of plasma levels of the other steroids simply allows to detect a higher proportion of cases of biochemical hyperandrogenism.…”

Section: ]mentioning

confidence: 99%